Graph AI generates neurological hypotheses validated in molecular, organoid, and clinical systems
图神经网络生成神经疾病假说并验证于分子、类器官和临床系统
机构 * Department of Biomedical Informatics, Harvard Medical School(哈佛医学院生物医学信息学系) ; Wyss Institute for Biologically Inspired Engineering at Harvard University(哈佛大学生物启发工程研究所) ; Department of Neurology, Massachusetts General Hospital(麻省总医院神经科) ; Department of Engineering Science, University of Oxford(牛津大学工程科学系) ; BD 2 : Breakthrough Discoveries for thriving with Bipolar Disorder(BD 2 : 双相情感障碍突破性发现) ; Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network(跨帕金森病科学协同研究网络) ; The Ivan and Francesca Berkowitz Family Living Laboratory Collaboration at Harvard Medical School and Clalit Research Institute(哈佛医学院伊万和弗朗西斯卡·伯克伍德家族生活实验室合作与克赖特研究所) ; Department of Genetics, Harvard Medical School(哈佛医学院遗传学系) ; Department of Neurology, Brigham and Women’s Hospital(布里洛妇女医院神经科) ; Broad Institute of MIT and Harvard(MIT和哈佛大学Broad研究所) ; The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center(纪念斯隆凯特琳癌症中心干细胞生物学中心) ; FutureHouse Inc.(FutureHouse公司) ; Clalit Research Institute, Innovation Division, Clalit Health Services(克赖特研究所创新部门,克赖特健康服务) ; Faculty of Computer and Information Science, Ben Gurion University of the Negev(贝内尔·戈里昂大学内盖夫分校计算机与信息科学系)
AI总结 PROTON通过异构图变换器生成并验证神经疾病假说,应用于帕金森病、双相情感障碍和阿尔茨海默病,揭示AI驱动的神经疾病发现路径。