A Multimodal Foundation Model of Spatial Transcriptomics and Histology for Biological Discovery and Clinical Prediction
一种结合空间转录组学和组织学的多模态基础模型用于生物发现和临床预测
机构 * Department of Radiation Oncology, Stanford University School of Medicine(斯坦福大学医学院放射肿瘤学系) ; Department of Statistics and Data Science, Yale University(耶鲁大学统计与数据科学系) ; Department of Medicine (Oncology), Stanford University School of Medicine(斯坦福大学医学院医学系(肿瘤学)) ; Department of Pathology, Stanford University School of Medicine(斯坦福大学医学院病理学系) ; Department of Neurosurgery, Stanford University School of Medicine(斯坦福大学医学院神经外科学系) ; Stanford Institute for Human-Centered Artificial Intelligence(斯坦福大学以人为本人工智能研究所) ; Perelman School of Medicine at the University of Pennsylvania(宾夕法尼亚大学佩雷尔曼医学院)
专题命中 其他多模态 :multimodal(title);multimodal foundation model(title);分类 cs.AI
AI总结 本文提出STORM模型,整合形态学特征、基因表达和空间上下文,提升空间领域发现并预测肿瘤类型基因表达,提高免疫治疗响应预测和预后诊断。
Comments 29 pages, 5 figures. This manuscript is a work in progress; further updates and revisions will be posted as they become available