Integrating gene regulatory priors into Transformer attention with scTransformer for interpretable scRNA-seq analysis
将基因调控先验知识整合到Transformer注意力中:scTransformer用于可解释的单细胞RNA-seq分析
机构 * Department of Information Engineering, University of Padova(信息工程系,帕多瓦大学) ; Department of Neuroscience, University of Padova(神经科学系,帕多瓦大学) ; Padova Neuroscience Center(帕多瓦神经科学中心) ; Information Systems Institute, University of Applied Sciences Western Switzerland, HES-SO Valais(应用科学西瑞士信息系统研究所,HES-SO瓦莱大学) ; Department of Comparative Biomedicine and Food Science, University of Padova(比较生物医学与食品科学系,帕多瓦大学) ; Padua Center for Network Medicine, University of Padova(帕维亚网络医学中心,帕多瓦大学)
专题命中 评测与基准 :foundation model(abstract);分类 cs.LG
AI总结 提出scTransformer,首次将基因调控先验知识嵌入Transformer注意力机制,通过约束信息流学习生物有意义的表示,在疾病相关单核RNA-seq数据上提升分类精度和细胞类型分离,注意力模式与已知调控程序一致。