Imputation-free transformer learning enables robust Alzheimer's disease prediction and calibrated uncertainty quantification across heterogeneous clinical cohorts
无插补变压器学习实现跨异构临床队列的稳健阿尔茨海默病预测和校准不确定性量化
Christelle Schneuwly Diaz, Narmina Baghirova, Duy-Thanh Vu, Duy-Cat Can, Gilles Allali, Philippe Ryvlin, Oliver Y. Chén
机构
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Platform of Bioinformatics(生物信息平台)
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Lausanne University Hospital(洛桑大学医院)
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Faculty of Biology and Medicine(生物学与医学学院)
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University of Lausanne(洛桑大学)
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Leenaards Memory Centre(Leenaards记忆中心)
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Department of Clinical Neurosciences(临床神经科学系)
Comments11 pages, 3 figures. v4: retitled; adds a dataset-by-representation interaction test (+0.097, 95% CI [+0.032,+0.160], p=0.001) and seed stability for both datasets, replacing the earlier claim that both within-dataset intervals excluded zero (the Memento10k bound was -0.0003); discloses that the pre-specified hypothesis returned NO-GO; adds a regularization-grid check