Fusion Learning from Dynamic Functional Connectivity: Combining the Amplitude and Phase of fMRI Signals to Identify Brain Disorders
融合动态功能连接:结合fMRI信号的幅度和相位识别脑疾病
Jinlong Hu, Jiatong Huang, Zijian Cai
AI总结 提出多尺度融合学习框架MSFL,结合滑动窗口相关和相位同步两种互补的动态功能连接特征,在自闭症和抑郁症数据集上显著优于现有模型。
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基于静息态功能磁共振成像(fMRI)的动态功能连接(dFC)已广泛应用于脑科学研究。滑动窗口相关(SWC)方法通过计算脑区对信号幅度时间序列之间的相关系数,是构建dFC的常用方法。在本研究中,我们提出了一种集成方法,结合fMRI信号的幅度和相位信息,以提高脑疾病的检测能力。具体而言,我们引入了一个多尺度融合学习框架MSFL,该框架利用来自SWC和相位同步(PS)的两种互补dFC特征。其中,SWC捕获幅度相关性,而PS测量dFC内的相位相干性。我们使用两个公开数据集(ABIDE I和REST-meta-MDD)评估了MSFL在分类自闭症谱系障碍和重度抑郁症方面的有效性。结果表明,MSFL显著优于现有比较模型。此外,我们使用SHAP框架进行了模型解释分析,表明来自SWC和PS的两种dFC特征均有助于检测脑疾病。
Dynamic functional connectivity (dFC) derived from resting-state functional magnetic resonance imaging (fMRI) has been extensively utilized in brain science research. The sliding window correlation (SWC) method is a widely used approach for constructing dFC by computing correlation coefficients between amplitude time series of signals from pairs of brain regions. In this study, we propose an integrated approach that incorporates both amplitude and phase information of fMRI signals to improve the detection of brain disorders. Specifically, we introduce a multi-scale fusion learning framework, namely MSFL, which leverages two complementary dFC features derived from SWC and phase synchronization (PS). Here, SWC captures amplitude correlations, while PS measures phase coherence within dFC. We evaluated the efficacy of MSFL in classifying autism spectrum disorder and major depressive disorder using two publicly available datasets: ABIDE I and REST-meta-MDD, respectively. The results indicate that MSFL significantly outperforms existing comparative models. Moreover, we performed model explanation analysis using the SHAP framework, which showed that both types of dFC features from SWC and PS contribute to detecting brain disorders.