Physical activity plays a vital role in human health. Its entire distribution differs among people. Commonly used summary measures cannot describe this distributional pattern. We present a distribution-based analytical approach to describe physical activity by modeling individual-level activity-intensity patterns through hazard functions derived from wrist-worn accelerometer data. We analyzed minute-level Monitor-Independent Movement Summary (MIMS) data of 4297 adults with seven continuous days of device wear from the 2011- 2012 National Health and Nutrition Examination Survey (NHANES). We derived a nonparametric activity-intensity hazard using a survival-based approach for each individual on a common intensity grid, treating both the hazard curves from MIMS and their log-transformed MIMS as functional objects. We used functional principal component analysis (FPCA) on both scales of MIMS to characterize dominant modes of variation in activity-intensity distributions. Group-wise mean hazard functions showed little difference at lower intensity levels, while we observed a substantial difference at higher intensity levels. Our results demonstrate that hazard-based functional representations for capturing differences in physical activity intensity distributions across individuals offer a flexible and interpretable way to characterize heterogeneity. This approach works better than mean-based summaries and supports principled comparisons of physical activity patterns across population subgroups.

A game of chess is a stream: a time-ordered sequence of moves, each carrying an engine evaluation, a measure of accuracy, a measure of position complexity, and a clock reading. We model a game as a multivariate path and apply the signature transform of rough-path theory to obtain a reparametrization-invariant, graded feature set that records the order and interaction of in-game events without a parametric likelihood. We show that a player's law of play is identifiable from the expected signature up to tree-like equivalence, construct a signature-kernel two-sample test on path space, and recast cheating detection as an anytime-valid sequential test: a signature conformance score becomes an e-process whose error is controlled for every sample size at once by Ville's inequality, with fluctuations calibrated on the moderate-deviation scale. The discriminating information lives in the signature's Levy areas, which measure whether accuracy rises precisely when positions become hard--the fingerprint of engine assistance that aggregate match-rate statistics discard. In a controlled study the test holds exact type-I control and detection power rises from negligible for subtle assistance to 0.98 for blatant assistance, with a median detection time matching the growth-rate prediction. Calibrated to Magnus Carlsen's documented elite accuracy, the monitor does not flag world-champion-level play; and we exhibit cheating strategies that leave every aggregate statistic, including the best-move-frequency z-score of the Regan system, unchanged yet are caught cleanly by the signature--making precise how an order-aware, anytime-valid test strengthens the prevailing approach to chess anti-cheating.

Two-sample IV is a popular estimation method when the outcome and treatment variables are available in different samples, whereas instruments are available in both samples. The standard estimator is two-sample two-stage least squares estimator, which is efficient under homoskedasticity and homogeneity of the samples. We develop a robust two-step procedure for efficient estimation under general heteroskedasticity and heterogeneity of the samples, and propose a related two-sample Hansen overidentification test. A key feature of our approach is that only summary statistics from the linear regressions of the reduced form and first-stage in the two samples are needed. These are the six objects of the estimated coefficient vectors, and the homoskedastic and heteroskedasticity robust estimated variance matrices. We further show that the first-stage F-statistic in the treatment sample can be used as a test for weak instruments in the standard way under homoskedasticity and homogeneity, with the relative bias here a proportional bias. We propose an extension of the effective F-statistic of Montiel-Olea and Pflueger (2013) for the heteroskedastic case, following the generalization in Windmeijer (2025). We illustrate the estimators and tests in an application studying the effect of education on voting behavior from Marshall (2019), with cluster robust inference.

Unanchored indirect treatment comparisons using single-arm studies or disconnected evidence are increasingly used in health technology assessment (HTA) when randomized evidence is unavailable. Existing methods, including matching-adjusted indirect comparison (MAIC) and simulated treatment comparison (STC), are generally limited to pairwise settings and typically estimate marginal effects in the comparator study population, which may differ from the decision-relevant population. We propose multilevel unanchored meta-regression (ML-UMR), a Bayesian regression framework for synthesizing individual patient data and aggregate data from fully disconnected evidence. ML-UMR extends multilevel network meta-regression (ML-NMR) to unanchored settings by jointly modeling individual- and aggregate-level data within a unified likelihood, enabling estimation of treatment-specific outcomes and both marginal and conditional effects across multiple treatments, studies, and target populations. ML-UMR distinguishes assumptions required to identify treatment effects from those required to transport results to target populations. As with all unanchored comparisons, valid inference relies on strong and often unverifiable assumptions, including conditional exchangeability, correct specification of the outcome model, and cross-treatment assumptions (e.g., shared prognostic factor assumption (SPFA)). ML-UMR does not lessen these requirements but makes them explicit within a unified framework and facilitates sensitivity analyses. In simulation studies, ML-UMR produced low bias and nominal coverage for comparator-population effects. Transportability to alternative populations depended critically on identifying assumptions: violations of SPFA led to bias under strong effect modification, whereas incorporating subgroup information restored near-unbiased estimation and nominal coverage.

The statistical modeling of consensus in Delphi data faces a critical bottleneck: the high dimensionality of questionnaire items relative to the limited sample size of expert panels. This rank deficiency leads traditional latent variable models, such as Principal Component Analysis, to be structurally unstable and prone to overfitting. Addressing this methodological gap, this study proposes a transition from variable-centric covariance models to network-centric connectivity models. By mapping item correlations onto a weighted graph topology, we present a simulation-based benchmark that utilizes community detection algorithms to identify latent thematic structures, effectively addressing the spectral instability and rank deficiency typical of high-dimensional, low-sample-size regimes. The research systematically evaluates the robustness of topological approaches based on structural density, information flow, and spectral partitioning against synthetic datasets designed to replicate the pathological conditions of consensus data, including ordinal scales and systemic noise. The central methodological contribution lies in demonstrating that collinearity among expert judgments - traditionally treated as statistical redundancy to be regularized - can be effectively reinterpreted as a topological signal of cohesion. This framework provides researchers with a structured and automated procedure for dimensionality reduction, ensuring structural stability and psychometric consistency even in small-sample regimes where standard factor analysis breaks down.

Large scale genetic datasets often aggregate the total allele counts of distinct genetic markers. Inferring haplotype frequencies (i.e.\ the frequency of multimarker alleles) from these pooled data is a challenge. Previous spatio-temporal modelling in this context has been limited to 3 markers due to the computational cost. In this work, we propose a nearest neighbor Gaussian process (NNGP) model to improve scaling with the number of markers and observations. To infer the parameters of our model, we develop a novel sequential Monte Carlo squared algorithm, which uses particle Gibbs with ancestor sampling to mutate the NNGP function values. The latter has a linear cost in the number of observations and the number of NNGPs, and can be applied to a broad range of NNGP models. As a case study, we analyse genetic data relating to antimalarial drug resistance in Africa, and show our scaling results empirically on a 3 and 6 genetic marker dataset.

The accurate calibration of interest rate models is central to market-consistent valuation and Economic Scenario Generators (ESGs). Traditional calibration methods for multi-factor models such as the G2++ model often rely on point estimates, neglecting the influence of specific market data and the quantification of estimation uncertainty. This paper develops a diagnostic framework embedding the calibration problem into non-linear regression theory. It shows that the common industry practice of minimizing the Root Mean Squared Relative Error (RMSRE) is equivalent to a Weighted Least Squares (WLS) problem. This equivalence yields the corresponding formulations for diagnostic tools, including the Weighted Hat Matrix for leverage analysis, Influence Functions for local sensitivity diagnostics, and the Functional Delta Method for local, boundary-respecting confidence intervals. The implementation uses an efficient Jacobian factorization that exploits the analytical tractability of At-The-Money (ATM) caps. The framework is applied to a dataset of Euro ATM caps covering the period 2016--2025. Our empirical analysis reveals a boundary-dominated leverage profile, repeated losses of effective dimensionality due to active parameter constraints, and a diagnostic regime shift in local parameter stability around the post-2022 market transition. The resulting message for actuarial model governance is that low RMSRE is not sufficient for calibration validation. We conclude by discussing the framework's applicability to general least-squares problems while highlighting the computational challenges for instruments lacking closed-form gradients, such as swaptions.

Competing risks are commonly observed in engineering fields and can bring challenges to time-to-event data modeling when the application scenarios are complicated. Recently, deep neural networks have received great attention for prediction with competing risks, due to their flexibility and high learning capability. However, the complexity of neural network structure brings extra difficulty in hyperparameter tuning based on different data inputs. Additionally, when an engineered system has complex physical structures with multiple hierarchical levels, treating all structural levels as a single group of inputs may fail to capture critical information. To address the issues, we propose a Structured Segmented Hazard Deep Neural Network (SSH-Net) for failure time prediction under cause-specific competing risks framework. Our approach associates neural network structure with data structures, and allows different covariate groups to impact the failure prediction through separate sub-networks. The neural network is constructed based on a cause-specific competing risks model. The SSH-Net outputs cause-specific hazard functions, and utilizes the penalized log-likelihood as the loss function. The prediction accuracy of SSH-Net is validated through simulation studies by evaluating the Brier score, the area under receiver operating characteristic curves (AUC), and the root mean square error (RMSE) of the predicted cause-specific cumulative incident function. We further demonstrate the model's ability to predict failure time distribution functions using the Titan GPU failure time data.

Many real-world networks are incomplete, making link prediction a fundamental challenge in network science. To train parameters and evaluate algorithms, observed links are usually divided into three subsets, namely training, validation, and probe sets. This division implicitly involves two sampling processes: first-stage sampling yields the probe set and second-stage sampling obtains the variation set. To date, our understanding of how these two sampling processes affect algorithm performance remains quite limited. To address this issue, we propose a sampling scheme called $β$-sampling, where the sampling probability of a link is proportional to the product of the degrees of its two endpoints raised to the power of $β$. Experiments on 45 real-world networks reveal that the structural characteristics of missing links, as simulated via varying probe sets, substantially impact prediction accuracy. When missing links tend to connect high-degree nodes, such links can be predicted accurately with ease. Furthermore, even with a fixed probe set, second-stage sampling still exerts a significant influence on prediction accuracy. Notably, the optimal second-stage sampling strategy differs from \textit{random sampling} (which randomly selects links to form the validation set) and \textit{consistent sampling} (which guarantees that links in the validation and probe sets share identical structural characteristics).

Preference-based post-training has become a central paradigm for aligning language models. A common data-collection strategy is to generate a small set of completions for each prompt and label the resulting comparison pairs. However, human preference labels are often much more expensive than generating additional completions, suggesting a different use of the same labeling budget: generate a larger pool of completions, but label only the most informative comparison pairs. This paper studies which pairs should be compared in preference-based post-training. We formulate comparison curation as a sampling-design problem and evaluate designs by the quality of the final policy under the preference-based post-training objective. We instantiate this framework for Direct Preference Optimization (DPO), analyzing how the choice of labeled pairs propagates through DPO training to downstream policy performance. Our main results provide matching upper and lower bounds on the post-training optimality gap of the DPO-trained policy. The bounds show that comparison selection affects downstream performance through a single design-dependent information matrix, which links label allocation to parameter estimation error and policy suboptimality. This yields an explicit optimization criterion for budgeted comparison curation and motivates practical sampling designs for selecting informative pairs from large generated completion pools. Experiments on synthetic settings and language-model post-training benchmarks show that the proposed designs consistently improve sample efficiency over common comparison-selection heuristics.

Probabilistic weather forecasting is undergoing rapid transformation with artificial intelligence (AI). In traditional numerical weather prediction, computing power can limit how well ensemble forecasts approximate the unknown statistical distribution of future states. AI models facilitate larger ensembles and are trained with probabilistic considerations, ideally leading to better uncertainty quantification. Forecasts from these state-of-the-art models are often considered well-calibrated. However, here we show that the statistical coverage of such models, the ultimate measure of calibration, can struggle, especially on extreme events. To address this shortcoming, we employ conformal prediction, a class of statistical methods that mathematically guarantees coverage under no distributional assumptions, unlike previous post-processing techniques. We apply online conformal prediction to temperature and precipitation forecasts (including extremes) of three leading global weather models, GenCast, NeuralGCM, and AIFS-ENS, ensuring calibrated uncertainty at no expense to other probabilistic metrics. This post-processing method can be applied to any forecasting model.

In the last years, an anomalously high spreading of West Nile virus (WNV) has been observed in Italy, with particularly high peaks of infections in southern Lazio, Campania and Veneto regions. The main disease vector for WNV is represented by Culex pipiens mosquitoes, which spread human infections through their bites. Here, we investigate WNV fever epidemic diffusion during summer season 2025 in Italy through a computational approach based on a quantum version of the Game of Life (GOL) cellular automaton model. Specifically, human dynamics evolves according to the GOL rules, while stochastic dynamics of disease vectors, i.e., mosquitoes, as well as their interaction with humans, simultaneously occur. We show that this model fits the curves of cumulative infected individuals with high accuracy, either at local and average-regional level, with only optimization of mosquito birth and removal rates parameters. Furthermore, leveraging model flexibility, we show that changes in model parameters values elucidate system response to environmental variations. For instance, we quantify, e.g., the impact of mosquito spreading containment measures or sudden mosquito increasing abundance due to climatic and ecological changes. Overall, we provide a general, quantitative description of WNV infection spreading in Italy which could represent a supportive tool to test different environmental scenarios and could be useful to devise strategies for decision makers to monitor disease vector dynamics and to control consequent virus diffusion.

The correct inferential object in claims reserving is the conditional predictive distribution $p(R \mid \mathcal{D}, \hatθ)$, where $\mathcal{D}$ is the observed triangle held fixed. We refer to this as the conditioning principle. All existing bootstraps violate it by resampling functions of $\mathcal{D}$ inside the predictive loop, producing an $O(1)$ coverage error that does not vanish as the triangle grows. The Dirichlet-Gamma hierarchy admits a bootstrap that satisfies the principle exactly: $S^{IBNP}_i = X^{obs}_i (1-W_i)/W_i$ with $W_i \sim \mathrm{Beta}(c\hat{F}_{I-i}, c(1-\hat{F}_{I-i}))$ sampled directly from its predictive distribution. Only the allocation proportion $W_i$ is simulated; the observed triangle is held fixed. It thus inherits calibration from any development-proportion method (Chain-Ladder, Bornhuetter-Ferguson, Cape Cod, or other), making it model-agnostic. The coverage deficit is $O(I^{-1/2})$, independent of the number of development periods. Under compound Poisson data-generating processes the bootstrap is conservative for every $F_{I-i} \in (0,1)$: the predictive standard deviation analytically exceeds the true value by the factor $1/\sqrt{F_{I-i}}$. The ODP bootstrap violates the principle through two mechanisms in opposite directions: re-estimation inflates bootstrap variance under the ODP DGP, while missing accident-year frailty deflates it under frailty DGPs. The resulting coverage discrepancy is $Ω(1)$ regardless of $I$, providing a structural explanation for the cross-portfolio miscalibration heterogeneity documented by Meyers (2015). Chain-Ladder, Bornhuetter-Ferguson and Cape Cod emerge as credibility estimators under diffuse, informative and pooling priors respectively, with identical structure for counts and amounts. The concentration $c$ serves as a diagnostic: $\hat{c} < 30$ signals non-stationary development.

The Chain-Ladder (CL) method remains the dominant macro-level technique for claims reserving in non-life insurance, yet its classical formulation lacks a coherent probabilistic foundation. Existing stochastic extensions-including the Mack model and the Over-Dispersed Poisson (ODP) framework-provide measures of uncertainty but rely on second-moment assumptions or quasi-likelihood variance structures without clear generative interpretations. This paper develops a Negative Binomial Chain-Ladder (NB-CL) model that embeds the CL method within a full likelihood-based framework. The key contribution is a micro-level derivation showing that the negative binomial distribution arises naturally from a Poisson-Gamma construction: claims arrive according to a Poisson process with Gamma-distributed accident-year heterogeneity, and aggregation yields negative binomial incremental counts. This derivation gives the dispersion parameter $κ$ a structural interpretation as accident-year heterogeneity, rather than an ad-hoc overdispersion adjustment. The NB-CL model generalises the Poisson Chain-Ladder model in the limit $κ\to \infty$, shares the point estimates of the ODP model while differing in its variance function (quadratic vs. linear), and unifies the Chain-Ladder family within a single probabilistic hierarchy. A parametric bootstrap procedure is developed to incorporate both process and parameter uncertainty. Simulation studies confirm near-nominal coverage under correct specification once the dispersion parameter is bias-corrected, and a controlled degradation under model misspecification. Empirical illustrations on claim count data (Australian motor bodily injury) and paid amounts (Taylor-Ashe) document both the structural reading of $κ$ and the working-approximation status of the model in the amounts case.

In this paper, we derive the distribution of a two-dimensional (complex) random walk in which the angle of each step is restricted to a subset of the circle. This setting appears in various domains, such as in over-the-air computation in signal processing. In particular, we derive the exact joint and marginal distributions for two steps, numerical solutions for a general number of steps, and approximations for a large number of steps. Furthermore, we provide an exact characterization of the support for an arbitrary number of steps. The results in this work provide a reference for future work involving such problems.

This paper investigates the impact of carbon pricing under the EU Emissions Trading System (EU ETS) on the Italian electricity market, focusing on the carbon cost pass-through rate (CPTR) across market zones during Phases 3 and 4 (2016-2024). Using daily data, the study applies an econometric framework based on a linear regression model with autoregressive dynamics to estimate the extent to which carbon costs are reflected in wholesale electricity prices. It further incorporates robustness checks and quantile regression to assess how the CPTR varies across different fuel spread levels. The results show that carbon costs are positively and significantly transmitted to electricity prices, confirming the relevance of carbon pricing as a key market driver. However, pass-through is incomplete, with CPTR values consistently below 100%. At the national level, the pass-through estimate is around 32%, with no statistically significant change between Phase 3 and Phase 4. Substantial heterogeneity emerges across market zones: pass-through increases in the North, Centre-North, and Sardinia during Phase 4, while it declines in the Centre-South and Sicily, reflecting differences in generation mix, carbon intensity, and market conditions. Overall, the findings highlight the importance of market zones factors in shaping the effectiveness of carbon pricing in electricity markets.

The Swiss system is an increasingly popular competition format as it provides a favourable trade-off between the number of matches and ranking accuracy. However, there is no empirical study on the potential unfairness of Swiss-system chess tournaments if an odd number of rounds is played. To analyse this issue, our paper compares the number of points scored in the tournament between players who played one game more with the white pieces and players who played one game fewer with the white pieces. Using data from 28 highly prestigious competitions, we find that players with an extra white game score significantly more points. In particular, the advantage exceeds the value of a draw in the four Grand Swiss tournaments. A potential solution to this unfairness could be organising Swiss-system chess tournaments with an even number of rounds, and guaranteeing a balanced colour assignment for all players using a recently proposed pairing mechanism.

We propose a new method to estimate structural parameters in multi-way networks while controlling for rich structures of fixed effects. The method is based on a series of classification tasks and is agnostic to both the number and structure of fixed effects. In contrast to full maximum likelihood approaches, our estimator does not suffer from the incidental parameter problem. For sparsely connected networks, it is also computationally faster than PPML. We provide empirical evidence that our estimator yields more reliable confidence intervals than PPML and its bias-correction strategies. These improvements hold even under model misspecification and are more pronounced in sparse settings. While PPML remains competitive in dense, low-dimensional data, our approach offers a robust alternative for multi-way models that scales efficiently with sparsity. The method is applied to study the causal effect of a policy reform on spatial accessibility to health care in France.

Whether a variable is the cause of another, or simply associated with it, is often an important scientific question. Causal Inference is the name associated with the body of techniques for addressing that question in a statistical setting. Although assessing causality is relatively straightforward in the presence of temporal information, outside of that setting - the situation considered here - it is more difficult to assess causal effects. The development of the field of causal inference has involved concepts from a wide range of topics, thereby limiting its adoption across some fields, including meteorology. However, at its core, the requisite knowledge for causal inference involves little more than basic probability theory and regression, topics familiar to most meteorologists. By focusing on these core areas, this and a companion article provide a steppingstone for the meteorology community into the field of (non-temporal) causal inference. Although some theoretical foundations are presented, the main goal is the application of a specific method, called matching, to a problem in meteorology. The data for the application are in public domain, and R code is provided as well, forming an easy path for meteorology students and researchers to enter the field.

One obstacle to ``elevating'' correlation to causation is the phenomenon of confounding, i.e., when a correlation between two variables exists because both variables are in fact caused by a third variable, called a confounder. The situation where the confounders are measured is examined in an earlier, accompanying article. Here, it is shown that even when the confounding variables are not measured, under certain conditions it is still possible to estimate the causal effect via a regression-based method that uses the notion of instrumental variables. Using a meteorological data set, similar to that in the sister article, a number of different estimates of the causal effect are compared and contrasted. It is shown that the instrumental-variable estimates of causal effect depend on the choice of the instrumental variable, and that meteorological considerations are important in resolving the ambiguity. R code is provided for generating all of the results, and numerous directions for future work are outlined.

The drastic changes in the global economy, geopolitical conditions, and disruptions such as the COVID-19 pandemic have impacted the cost of living and quality of life. It is essential to comprehend the long-term implications of the cost of living and quality of life in major economies. A transparent and comprehensive living index must include multiple dimensions of living conditions. In this study, we present an approach to quantifying the quality of life through the Global Ease of Living Index that combines various socio-economic and infrastructural factors into a single composite score. Our index utilises economic indicators that define living standards, which could help in targeted interventions to improve specific areas. We present a machine learning framework to address missing data for certain economic indicators in specific countries. We then curate and update the data and use a dimensionality reduction approach (Principal Component Analysis and Factor Analysis) to create the Ease of Living Index for major economies since 1970. Our work significantly adds to the literature by offering a practical tool for policymakers to identify areas needing improvement, such as healthcare systems, employment opportunities, and public safety. Our approach with open data and code can be easily reproduced and applied to various contexts, providing transparency and accessibility for ongoing research and policy development in quality-of-life assessment.

Ongoing advancements in microbiome profiling have provided unprecedented insights into the molecular dynamics of microbial communities, sparking a surge of interest in uncovering the microbiome's critical role in human health. Identifying microbial features linked to clinical outcomes, however, remains challenging due to the high-dimensional, sparse, and compositional nature of microbiome data. Additionally, many microbial taxa, although classified as distinct, may share functional roles, complicating traditional variable selection methods. To overcome these obstacles, we introduce Bayesian Regression with Agglomerated Compositional Effects (BRACE), a novel approach using a spike-and-cluster prior combining Bernoulli activity indicators, an Ewens exchangeable partition prior on the finite active set, and a projection-based constrained Gaussian prior on cluster effects to perform data-adaptive clustering and variable selection. The methodological innovation of our work lies in how we combine the Ewens partition prior with a projection-based constrained Gaussian on the cluster atoms to enforce the sum-to-zero constraint. BRACE groups microbial taxa with similar effects on the outcome, yielding more interpretable models while enabling effective dimension reduction. Through comprehensive simulations and a real-world application examining the influence of oral microbiome composition on insulin resistance, we demonstrate BRACE's superior performance over existing methods, particularly in identifying key features with shared effects on outcomes.

Environmental problems are receiving increasing attention in socio-economic and health studies, fostering advances in recording and data collection of related real-life processes. However, traditional tools for data processing are often found too restrictive as they do not account for the rich nature of such data sets. In this paper, we propose a simple statistical perspective on forecasting environmental data collected sequentially over time across some predefined geographic region. We treat such data set as a surface (or functional) time series with a possibly complicated geographical domain. Using techniques from functional data analysis, we develop a forecasting methodology that allows to account for both geographic and temporal dependencies. This methodology allows integration of traditional multivariate techniques to provide forecasts surfaces. We demonstrate the practical value of our approach with a forecasting example of ground-level ozone concentration across Germany, showcasing its effectiveness and potential for broad application.