Estimating Spatially-Smoothed Fiber Orientation Distribution from Diffusion-MRI Experiments
从扩散MRI实验估计空间平滑的纤维取向分布
Jilei Yang, Seungyong Hwang, Mengjie Shi, Jie Peng
AI总结 提出最近邻自适应回归模型(NARM),通过加权局部似然估计和空间邻域嵌套实现纤维取向分布(FOD)的空间自适应估计,引入体素级重缩放和数据驱动停止规则防止过平滑,并基于配置感知策略选择相似性平滑参数,在模拟和人类连接组项目数据中提高了估计准确性和可重复性。
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扩散加权磁共振成像(D-MRI)是一种非侵入性体内技术,用于探测生物组织的微观结构架构。在每个体素处,纤维取向分布(FOD)表征局部纤维构型和方向,因此是D-MRI分析中的核心估计对象。我们提出了最近邻自适应回归模型(NARM),这是一种用于FOD估计的空间自适应框架,它在嵌套的空间邻域上执行加权局部似然估计,其中权重联合编码相邻FOD之间的空间邻近性和相似性,通过最优传输或Hellinger距离测量。为了防止过平滑同时保留结构异质性,我们引入了体素级重缩放方案和基于最小最近邻相异性的数据驱动停止规则。我们进一步开发了一种配置感知策略来选择相似性平滑参数,使平滑强度能够适应局部纤维复杂性。模拟研究表明,相对于体素级方法和现有的空间平滑方法PMARM,NARM提高了FOD估计精度。对人类连接组项目的重测数据的应用还表明,NARM产生了更可重复的FOD估计。实现细节以及模拟和真实数据分析的脚本可在以下网址获得:https://github.com/DMRIdotL/NARM
Diffusion-weighted magnetic resonance imaging (D-MRI) is a noninvasive in vivo technique for probing the microstructural architecture of biological tissues. At each voxel, the fiber orientation distribution (FOD) characterizes local fiber configurations and orientations and is therefore a central object of estimation in D-MRI analysis. We propose the Nearest-Neighbor Adaptive Regression Model (NARM), a spatially adaptive framework for FOD estimation that performs weighted local likelihood estimation over nested spatial neighborhoods, where the weights jointly encode spatial proximity and similarity among neighboring FODs, measured by either the optimal transport or Hellinger distance. To prevent over-smoothing while preserving structural heterogeneity, we introduce a voxel-wise rescaling scheme and a data-driven stopping rule based on minimum nearest-neighbor dissimilarity. We further develop a configuration-aware strategy for selecting the similarity-smoothing parameter, allowing the smoothing strength to adapt to local fiber complexity. Simulation studies demonstrate that NARM improves FOD estimation accuracy relative to voxel-wise methods and the existing spatial smoothing approach PMARM. Application to test-retest data from the Human Connectome Project additionally shows that NARM yields more reproducible FOD estimates. Implementation details and scripts for the simulation and real data analyses are available at https://github.com/jie108/NARM