The rise of edge-based machine learning has enabled distributed adaptation of language models across mobile and IoT devices, offering privacy preservation and real-time responsiveness. However, distributed fine-tuning of language models on untrusted or heterogeneous edge nodes introduces new vulnerabilities. Compromised or unreliable devices can inject poisoned updates, leading to stealthy model manipulation or convergence degradation. Classical defenses such as robust aggregation or temporal anomaly detection operate on a single global model and are therefore limited in detecting coordinated or persistent poisoning. This work proposes a new system-level defense based on model multiplicity. Instead of maintaining one global model, the system rotates or concurrently trains multiple small language models (e.g., DistilGPT-2), each updated by independently sampled subsets of edge nodes. These models evolve under distinct training trajectories, creating multiple independent views of the same distributed population. Divergence between models quantified through gradient similarity, loss evolution, or parameter variance serves as a signal of anomalous or adversarial behavior. When one model deviates significantly from the ensemble mean, the system flags its contributing nodes for isolation or re-weighting. We implement this framework and evaluate it on edge-scale simulations of Small Language Model (SLM) training under varying heterogeneity and attack conditions. Results show that model multiplicity enables earlier and more reliable detection of poisoning compared to classical single-model defenses such as Flanders and Robust methods. Our findings demonstrate that diversity in model evolution can serve as a practical and effective defense mechanism for secure distributed learning on resource-constrained edge devices.

LLM-agent workflows chain model calls and tool invocations, and spend most of their wall-clock time waiting on upstream operations before downstream ones can start. Speculative execution can reclaim that idle time by launching a downstream operation with a predicted upstream input, but here each speculation costs real money (per-token billing) and its success probability is hard to estimate and drifts over time. This paper presents a method organized around five design decisions: (D1) start a downstream operation before its upstream completes; (D2) price each speculation in real dollars at separate input and output rates; (D3) expose a single operator dial for latency versus cost; (D4) decide via an expected-value rule with a failure-weighted cost term and a preference-adjusted threshold; and (D5) estimate the success probability with a Bayesian Beta-Binomial posterior whose prior is keyed to a dependency-type taxonomy. Variants of these ideas appear in recent work; the combination, with every decision logged in dollars, is what is new. The rule fires only on edges passing an admissibility precondition (side-effect-free, idempotent, or stageable behind a commit barrier), since a wrong speculation is rolled back by re-execution, which refunds tokens but cannot un-send an irreversible side effect. We specify the runtime mechanics, a closed-form result that the rule self-limits as the upstream branching factor grows, a five-stage calibration pipeline (offline replay, shadow, canary, online calibration, drift-triggered kill-switch), and a workload-fit rubric over eight production archetypes. Contrast tables against the four closest published systems (DSP, Speculative Actions v2, Sherlock, B-PASTE) show differentiators on every dimension, and a synthetic validation suite confirms the predicted decision boundary, probability threshold, posterior recovery, and streaming-cancellation behavior.

We measure how well current large language models coordinate as multiple agents sharing a common resource, using the dining philosophers problem as a clean test bed. Across 630 episodes spanning seven models and three philosopher counts, four frontier closed-source systems reach mean reward 0.45 to 0.87 and Mistral-Small 24B reaches 0.83 to 0.99, while Qwen3-14B reaches 0.13 to 0.35. We then ask whether group relative policy optimization (GRPO) on rollouts from the task itself can close the gap and find that it cannot: a Welch's t-test on per-episode reward at five philosophers gives p = 0.66 and a Hedges' g of -0.11, with no statistically significant change at ten or fifteen philosophers either. Two further observations qualify the result. The training reward of both 8B and 14B runs peaked at step nine and then declined, so the default saved checkpoint at step 15 is strictly worse than several earlier ones. The four-term reward we use admits a degenerate maximum at zero actions, which DeepSeek-R1-Distill-Qwen-7B and Mistral-Small 24B at five philosophers both inhabit, with mean reward 1.0 and 0.83 respectively at zero meals. The bottleneck for an open-weight 14B model on multi-agent coordination is not training compute but training methodology: reward shaping that does not collapse to a no-action maximum, checkpoint discipline that does not depend on the final step, and curriculum across problem scales.

Schema matching, a critical task for integrating data from diverse sources, seeks to identify correspondences between columns across different schemas. In multi-table holistic schema matching, columns with similar semantic meaning may reside in tables with different contexts due to heterogeneous schema designs, where similarity-based techniques are inadequate. The focus of this paper is exploiting referential context into schema matching by introducing RACT learning and prediction, a self-supervised framework enabling the probabilistic retrieval of candidate tables for source columns to constrain relevant column candidates. Experiments demonstrate that this approach outperforms similarity-based baselines on matching multi-table schemas. In subsequent matching experiments, constraining the column search space via top-t tables improves both average matching precision and completeness by up to +70%.

Black-box variational inference (BBVI) is a methodology for posterior approximation that relies on stochastic optimization. In practice, the stochastic optimizers underpinning BBVI generally require extensive problem-specific tuning, which undermines its promise as a truly "black box" inference algorithm. However, over the past decade, many new adaptive stochastic optimization algorithms have been developed that reduce or remove entirely the need for tuning. In this work, we investigate this new collection of adaptive methods in the context of BBVI, with the goal of establishing the current state of the art in tuning-free optimization-based inference. In particular, we present a large-scale empirical evaluation of 56 stochastic gradient-based optimization algorithms applied to 1092 Bayesian inference optimization problems, involving over 550,000 individual optimization runs and 15 core-years of compute. The optimization algorithms we evaluate are chosen to represent a wide spectrum of recent approaches and the benchmark problems are chosen to span a range of difficulty, with posterior target dimension 1-10^4, condition number 1-10^8, and a range of variational families. Our results show that no single method dominates, but running a selection of 5 algorithms suffices to reliably get close to the best-possible observed performance. We thus provide a strong baseline for applications where expert tuning is not possible and for comparison when developing new stochastic optimization algorithms.

A concert is a collective experience, but recorded performance videos are typically watched alone, stripping away the shared audience presence that makes concerts feel eventful. We investigate whether persona-based LLM audience agents can recreate aspects of this collective experience by generating real-time fan chat alongside a K-pop performance video. We present a multi-agent system in which ten LLM agents react through live-chat messages, comparing a persona-conditioned audience (each agent assigned a distinct fan identity, bias, and chat style) with a no-persona baseline. In a within-subjects pilot with K-pop fans (N=11), persona conditioning substantially improved model-level chat quality and perceived naturalness, but did not translate into differences in social connectedness, engagement, or affective response. Interviews suggest that online K-pop concert chat may operate as collective monologue rather than interpersonal dialogue, and that meaningful participation depends on shared identification with the specific artist and fandom. Persona conditioning can make LLM audiences appear more natural, but culturally meaningful collective experience may require deeper alignment between persona, crowd behavior, fandom identity, and user expectations.

Many-body GW-Bethe-Salpeter equation calculations are essential for accurate simulations of electronic structure and optical properties in modern low-dimensional nanomaterials. However, these methods are computationally demanding and can exhibit localized numerical instabilities or convergence failures that are difficult to detect within high-throughput workflows. We introduce an agent-guided multi-fidelity framework for correcting GW-Bethe-Salpeter excited-state landscapes in strained MoS2-WS2 bilayers. Across stacking registries, strain branches and reciprocal-space samplings, the workflow identifies spike-like excursions, near-zero-gap collapse and cross-fidelity inconsistencies associated with fragile long-wavelength dielectric screening. A structural agent evaluates calculations by assigning confidence weights and selectively using a small number of high-accuracy reference points. Machine learning models then transfer information across related systems and apply Gaussian process corrections to recover improved quasiparticle gaps and exciton binding energies, with calibrated uncertainty estimates. The approach corrects numerically induced artifacts without erasing physical strain dependence and substantially improves agreement with higher-fidelity references relative to a no-agent baseline. These results show that reliable surrogate learning for excited-state materials requires explicit diagnosis of numerical fragility, not direct interpolation of raw first-principles data points. The proposed framework is readily transferable to other optoelectronic nanomaterials characterized by strong quantum confinement, such as quantum dots, nanoribbons, layered two-dimensional semiconductors, and hybrid perovskite nanostructures.

Standard AI red teaming evaluations reduce adversarial campaigns to a single binary outcome, attack success rate (ASR), not taking into account the sequential structure of how models resist or yield to attacks. We propose applying process mining, a discipline for discovering and analyzing process models from event logs, to red teaming traces. We conduct a controlled experiment pitting 60 HarmBench prompts against two LLMs, GPT-OSS 120B and Llama 3.3 70B, using 10 prompt mutation strategies over up to 110 attempts per prompt. From the resulting 8,575 scored events we extract Directly-Follows Graphs (DFGs) and state transition matrices that reveal structurally distinct defense profiles invisible to ASR alone: GPT-OSS exhibits a near-absorbing refusal state, while Llama presents multiple porous escape routes from refusal to getting successfully jailbroken. We further show that mutator effectiveness is asymmetric across models and that time-to-jailbreak distributions differ by an order of magnitude.

I report a case study in AI-paired software engineering: five working ports of a vector illustration application across Rust, Swift, OCaml, Python, and browser-based platforms, built by a single developer in approximately 120 evening hours. The methodology pairs AI-assisted implementation with two safeguards -- a precise executable YAML specification serving as the single source of truth, and parallel implementations functioning as a built-in differential-testing layer. The five ports share a 23{,}000-line specification; per-port native code ranges from 0 to roughly 95{,}000 lines, reflecting the specification's escape hatch. I argue that AI-paired engineering, conditional on these two safeguards, makes feasible scope of work that conventionally requires multiple developer-years, and frame the methodology as a revival of N-version programming, a 1980s approach abandoned on cost grounds that AI changes. The paper reports concrete artifacts and honest limitations of the single-developer case study.

Culture is the most insidious vector of gradual human disempowerment by AI: unlike economic or political displacement, cultural displacement attacks the very preferences and values through which humans recognise and resist disempowerment itself. We argue that existing AI governance frameworks suffer from a critical blind spot by treating cultural impact as secondary to economic and safety concerns. This paper develops \emph{memetic capture} as a unifying concept for AI-driven cultural disempowerment, and proposes the \textbf{Cultural Pluralistic Governance Framework (CPGF)}, a four-tier policy architecture combining quantitative cultural influence metrics, democratic value assemblies, pluralistic deployment standards, and transnational coordination mechanisms. We argue that pluralism is not merely an ethical requirement for such governance but a structural necessity: monocultural AI governance accelerates the very disempowerment it claims to prevent. We identify concrete policy levers, discuss implementation tensions, and outline a research agenda at the intersection of pluralistic alignment and cultural AI governance.

MOLOT (Malicious Operational Logic Observation Transformer) is a static malicious-code detection system designed for SAST setup where package metadata, maintainer history, and dynamic execution traces may be unavailable or unreliable. The system represents source code as behavior sequences derived from static call graphs, includes an explanation stage that ranks suspicious behavior activities and maps them back to source-code locations. The approach is evaluated on Python and JavaScript packages from PyPI and npm, compared with opensource detection tools, and validated under product constraints including runtime, memory use, and false-positive rates observed in a real moderation workflow. We also release Open Malicious-Code Bench, a public benchmark for reproducible evaluation of malicious-package detection methods. The results show that static behavior-sequence modeling can provide accurate, explainable, and deployable malicious-code detection for modern DevSecOps workflows.

Classical spectral descriptors such as the Heat Kernel Signature and Wave Kernel Signature are widely used for non-rigid 3D shape retrieval, yet their failure modes remain poorly understood. We present a frequency-scale saliency framework that audits these descriptors by quantifying the retrieval-level contribution of each descriptor scale interval through ablation. We introduce class spectral fingerprints to characterize category-level scale dependence, and show that descriptor similarity between class pairs is substantially correlated with retrieval failure, with a Spearman correlation of 0.479. Experiments on SHREC'11 demonstrate that short scales dominate retrieval performance while long scales are harmful, that HKS and WKS exhibit distinct scale dependence patterns, and that saliency-weighted retrieval improves mAP on hard categories by 0.156, with cross-fold and random-weight controls confirming that the gain is stable and not due to arbitrary reweighting.

We propose a new framework for optimisation over non-Archimedean spaces inspired by Berkovich geometry. Specifically, we introduce polydisc spaces, which consists of products of closed balls over a non-Archimedean field. These spaces retain the rigid hierarchical structure of the non-Archimedean field whilst acquiring many desirable geometric features absent from it. We show that metric trees embed naturally into these spaces, demonstrating their capacity to represent hierarchical data. We study their metric geometry, establishing properties such as geodesic uniqueness, confirming their comaptibility with classical optimisation techniques. We further propose a class of real-valued functions given by linear combinations of absolute values of polynomials. These functions admit a piecewise polynomial description along geodesics and satisfy a universal approximation property. We formulate a theory of optimisation on polydisc spaces: we prove existence of minimisers and explore algorithms for finding them. We provide an accompanying open-source Julia library implementing the core objects and optimisation procedures introduced.

Foundation models for astronomical surveys offer powerful learned representations that can be transferred to downstream regression tasks such as galaxy property estimation. However, point predictions alone are insufficient for scientific inference; reliable uncertainty quantification (UQ) is essential. We compare seven UQ methods on galaxy property regression using frozen AION-1 foundation-model embeddings, predicting redshift, stellar mass, stellar-population age, gas-phase metallicity, and specific star-formation rate, from Legacy Survey photometry/imaging and DESI spectra, with PROVABGS-derived labels. Distribution-free conformal methods achieve marginal coverage within $\sim$1\,pp of the nominal 90\% across all properties, while non-conformal baselines (Deep Ensembles, MC~Dropout) fail to calibrate reliably. Among conformal approaches, Conformalized Quantile Regression (CQR) delivers the best coverage in the bin with the poorest model predictions. More importantly, only the Locally Valid and Discriminative (LVD) framework -- particularly when operating on AION-1 embeddings -- also provides finite-sample \emph{local validity}, producing intervals that adapt to each galaxy's local prediction difficulty rather than relying on marginal guarantees alone. These results establish conformal prediction, and LVD in particular, as the preferred UQ framework for uncertainty-aware inference on foundation-model embeddings in astrophysics.

Quantum combinatorial optimization offers theoretical advantages for complex financial modeling, but physical implementation on Noisy Intermediate Scale Quantum (NISQ) devices is severely constrained by hardware topology. This study presents a hardware benchmarking analysis between a Hardware Efficient Variational Quantum Neural Network (HE-VQNN) and the Warm Start Quantum Approximate Optimization Algorithm (WS-QAOA) for a hybrid Mean Variance and Conditional Value at Risk (CVaR) portfolio objective. By implementing a novel classical quantum hybrid proxy matrix to bypass the CVaR auxiliary qubit bottleneck, we map up to 16 assets from the NIFTY 50 index onto an IBM heavy hex processor. We systematically quantify algorithmic resilience to the "SWAP tax" incurred during routing. Empirical results reveal a critical operational trade-off: WS-QAOA provides exact theoretical mapping but suffers catastrophic hardware decoherence due to exponential nonlocal gate overhead. Conversely, HE-VQNN preserves hardware coherence but lacks the mathematical expressibility to capture dense tail risk asset correlations. This study exposes the limitations of dense financial optimization on current architectures forces an nonviable choice between algorithmic inexpressibility and hardware decoherence. This is indicative of a deeper limitation as to what can and cannot be done with NISQ computers lacking in all-to-all connectivity.

Displacement time series from Global Navigation Satellite Systems (GNSS) are essential for a wide range of applications, including monitoring tectonic crustal deformations and investigating the different stages of the earthquake cycle. Machine learning methods have proven promising for GNSS applications; however, most remain fully supervised. This creates a bottleneck as labeled data are scarce, even though large amounts of unlabeled GNSS data are freely available. We present GNSS-FM, a self-supervised foundation model for daily GNSS time series. The model uses a dual-stream input combining displacement and velocity-like increments, and is pretrained using a masked latent prediction objective with vector-quantized targets adapted from wav2vec 2.0, with several modifications for geodetic data. Pretrained on data from over 17,000 globally distributed GNSS stations, an analysis of the learned codebook suggests that the representations capture the main signal types in GNSS displacement data, including seismic offsets, tectonic drift, and seasonal patterns. The foundation model is later fine-tuned on two downstream tasks, namely 90-day displacement forecasting and seismic step localization, where it outperforms strong task-specific baselines in both cases. These results show that self-supervised pretraining is a promising approach for GNSS time series analysis.

This work proposes a lightweight 2D-U-Net-based framework for segmenting five abdominal organs in large field-of-view 3D CT scans. The method combines coarse-to-fine segmentation, predictions from multiple anatomical planes, and additional fuzzy 3D spatial maps that provide anatomical location cues to improve segmentation accuracy. We combine multi-planar 2D-U-Net models augmented by a spatial occurrence map. The approach involves two main stages. First, the abdominal volume of interest region is detected by traversing the whole scan axially with a 2D-U-Net and determining the x-y-z-minimum and -maximum extents of the 5 abdominal organs of interest. Second, we use spatial occurrence maps to enhance our multi-planar 2D-U-net architecture inside the bounds from the former stage. The method is evaluated on 80 CT scans from various public sources. The results show Dice improvements of about 4% at maximum compared to the same model trained without spatial occurrence maps.

Adversarial attacks pose a serious and growing threat to Machine Learning (ML)-based Intrusion Detection Systems (IDS), where imperceptible perturbations to network flow features can systematically mislead classifiers into accepting malicious traffic as benign. The IDS-Anta framework partially addresses this through Z-score normalization, Singular Value Decomposition (SVD), and Multi-Armed Bandit (MAB) classifier selection with Thompson Sampling, yet its classifier pool lacks sufficient structural diversity for robust adversarial resistance. This work introduces IDS-Anta++, which incorporates XGBoost and LightGBM gradient boosting models into the ensemble and wraps the extended pool in a three-layer black-box defense: Isolation Forest anomaly screening, median feature smoothing, and six-way majority voting. Experiments conducted on CIC-IDS-2017, CEC-CIC-IDS-2018, and CIC-DDoS-2019 under both Fast Gradient Sign Method (FGSM) and Zeroth Order Optimization (ZOO) attacks confirm detection accuracy above 99% on clean data, with measurable robustness gains under adversarial conditions relative to the baseline IDS-Anta configuration.

Progress in AI-driven crystal materials science has so far been carried by narrow architectures purpose-built for individual tasks -- graph neural networks for property prediction, diffusion and flow-matching models for crystal generation -- each excelling within its niche yet unable to act as a shared backbone across the full spectrum of materials problems. Generative large language models offer a fundamentally different paradigm, in which structural representation, quantitative prediction, and structure-activity reasoning can be unified within one model, but the materials community has yet to see this paradigm realized at a level competitive with established narrow specialists. Here we present MatMind, a generative foundation model purpose-built for crystal materials science under this paradigm, developed through the coordinated activation of structure-activity knowledge and physics-informed feedback within a progressive training framework -- combining structure-activity knowledge injection, a dual-head architecture that jointly trains language reasoning and numerical regression in a shared representation space, and multi-objective physics-informed reinforcement learning over stability, novelty, and structural diversity. Across three task families, MatMind attains the lowest mean absolute error on energy above hull, bulk modulus, and band gap -- surpassing graph neural network predictors purpose-built for these tasks -- reaches an S.U.N. rate of 65.3% on unconditional crystal generation, and achieves a comparable multiplicative improvement on magnetization-density-conditioned generation, where only 21 positive samples exist within over 600000 training entries. By matching or surpassing narrow specialists on their own ground while operating within a single unified model, MatMind shows that the LLM-based paradigm can serve as a viable backbone for crystal materials science going forward.

Vision-Language Models (VLMs) have demonstrated strong performance across multimodal tasks, yet their safety robustness remains an open challenge. While prior work has shown that structured visual prompts such as flowcharts can effectively jailbreak VLMs, existing studies are largely limited to English-centric settings. In this paper, we introduce MLingualFC, a multilingual multimodal benchmark designed to evaluate jailbreak vulnerabilities of VLMs across diverse languages using structured flowchart representations. MLingualFC encodes harmful instructions into flowchart images across five languages (Hindi, Punjabi, Spanish, Romanian, and German). We evaluate state-of-the-art multilingual VLMs, including Qwen2.5-VL, Gemma-4, and Pangea, under a black-box threat model. Our results reveal significant multilingual safety gaps. Flowchart-based attacks achieve high attack success rates (ASR) in case of Latin script languages, demonstrating that visual encoding of harmful content effectively bypasses safety alignment across languages. In contrast, non-Latin script languages such as Punjabi exhibit substantially lower ASR, suggesting potential limitations in visual text recognition rather than stronger safety alignment. These findings highlight that current VLM safety mechanisms fail to generalize across languages and modalities. Resources are available at https://github.com/Rishabhpm23/MLingualFC

As atmospheric environmental prediction continues to improve, interpretable validation of pollution mechanisms and feedback processes has become a main challenge in atmospheric chemistry. Yet mechanism validation based on complex numerical models still relies heavily on expert knowledge: mechanistic hypotheses must be operationalized into executable experiments, and model outputs must be organized into traceable evidence. We present TianJi-Environ, an auditable AI Scientist for atmospheric-chemistry mechanism validation. TianJi-Environ establishes the first WRF-Chem-based multi-agent framework that autonomously drives complex atmospheric-chemistry simulations, converting mechanistic hypotheses into executable configurations, testing experiments, and evidence criteria. Using ozone response and particulate-matter feedback as two representative examples, we demonstrate TianJi-Environ's capability for mechanism validation. In a summertime ozone case over the North China Plain, the system detects directionally consistent aerosol-radiation-interaction signals in shortwave radiation and boundary-layer height, but judges the evidence for ozone response to NOx control to be incomplete. In a wintertime PM2.5 case over the Guanzhong Basin, it localizes the unsupported link to insufficient propagation from black-carbon perturbation to particulate response and missing diagnostics of vertical absorptive heating. These results show that TianJi-Environ makes expert-driven mechanism validation explicit, structured, and auditable, offering a reproducible paradigm for multi-agent systems coupled with complex atmospheric-chemistry models.

Generative recommendation formulates next-item prediction as autoregressive generation over semantic ID (SID) sequences derived from users' historical interactions, making modern recommender systems structurally similar to large language models (LLMs). As privacy and safety concerns grow, these systems increasingly require concept unlearning to remove sensitive or harmful concepts associated with items. However, existing LLM unlearning methods cannot be directly applied to generative recommendation. Unlike word tokens with explicit semantics, SIDs are abstract identifiers that are often shared by both forget and retain items, leading to severe conflicts between concept removal and recommendation utility preservation. To address this challenge, we propose TRACER, an end-to-end concept unlearning framework based on token reassignment. Rather than directly suppressing shared SIDs, TRACER reassigns concept-related items to alternative tokens that better facilitate forgetting while minimizing side effects on retained items. We further introduce a coherence regularizer to preserve semantic consistency among retain items during unlearning. Experiments on real-world recommendation datasets demonstrate that TRACER effectively removes target concepts while substantially better preserving recommendation utility than existing unlearning baselines.

AI agents are increasingly expected to complete long-horizon workflows that require sustained progress over hours, millions of tokens, and complex environments. Yet current agent benchmarks largely evaluate short-form tasks, such as single pull requests, small tickets, or 5-10 minute exercises, limiting our ability to measure agents' capabilities in planning, long-context understanding, and memory use. We introduce SWE-Marathon, a benchmark of 20 long-horizon tasks spanning software engineering and adjacent technical domains. Each task consists of a unique executable environment, a human-written reference solution, and a multi-layer verification suite. Logged agent attempts average 27.2M total tokens, making SWE-Marathon substantially longer-horizon than existing SWE and command-line agent benchmarks. Current frontier coding agents solve fewer than 30% of tasks. Failures often arise from poor self-verification, self-reported infeasibility, and premature termination. We also observe reward-hacking behavior in 13.8% of rollouts, where agents attempt to exploit the environment or verifier to bypass the intended workflow. SWE-Marathon includes adversarial review of test suites and execution environments, as well as multi-layer checks designed to prevent shortcut solutions. We release SWE-Marathon, evaluation code, and agent trajectories at https://swe-marathon.org/.

Differentiable programming offers transformative capabilities for scientific modeling, enabling gradient-based parameter estimation, sensitivity analysis, and data assimilation. Yet, migrating legacy codebases into differentiable frameworks remains a challenge. We present a five-phase LLM-based agentic pipeline that translates legacy Fortran into JAX: static dependency analysis determines module translation order from the full call graph; iterative compile-repair loops correct errors autonomously; and a Fortran reference oracle enforces numerical parity at the module level before integration and gradient verification. We instantiate and evaluate the pipeline on CLM-ml-v2, a 19,000-line Fortran land surface model, and analyze agent behavior across 73 module translation tasks. The resulting differentiable model computes the complete Jacobian in a single backward pass, recovers physical parameters in eight times fewer steps than gradient-free optimization, and achieves a 24 times wall-clock speedup over sequential Fortran at ensemble size N=2,048. Both the translated model and pipeline infrastructure are released as a reusable framework for differentiating other Earth system model components.

Electronic health records (EHR) pose large-scale multi-disease modeling problems in which many outcomes are rare and strongly influenced by shared risk factors. While modern approaches achieve strong predictive performance, they often treat diseases independently or rely on black-box architectures, offering limited insight into how risk factors organize disease risk and little principled uncertainty quantification. We introduce a Bayesian hypergraph inference framework that reframes multi-disease modeling around latent, risk-factor-modulated disease pathways. Risk factors act on hyperedges, latent disease subsets with shared risk patterns, allowing diseases to participate in multiple distinct pathways and enabling interpretable, higher-order structure beyond pairwise associations. A repulsion prior encourages parsimonious and identifiable structure, while posterior inference provides calibrated uncertainty over both disease groupings and risk-factor influence. To enable scalable inference on large EHR datasets, we develop a structured variational inference algorithm that preserves logical dependencies among hyperedge existence, disease membership, and pathway-level effects. Experiments on simulated data and UK Biobank demonstrate stable and interpretable disease pathway structure, well-calibrated uncertainty, improved estimation for rare diseases, and competitive predictive performance.

Spatial transcriptomics (ST) is a powerful tool for exploring biological properties dependent on structure, proximity, and interaction in tissue. The methods underpinning ST are developing rapidly but are limited in their ability to profile many thousands of genes at a subcellular scale. Although dissociated from tissue, it is known that the whole-transcriptome readouts of cells in single-cell RNA sequencing (scRNA-seq) retain information about their former in situ neighbourhoods, motivating computational methods to recover it. While paired ST and scRNA-seq datasets are scarce, each modality in its own right is abundantly available. We therefore propose to perform cross-modal translation between unpaired ST and scRNA-seq data. In this work we show that a single-cell foundation model can perform this translation via adversarial fine-tuning. We demonstrate that our method performs favourably against methods built for multi-omics translation.

Smartphone telephoto cameras are approaching a "telephoto physics wall": as pixel pitches shrink toward sub-0.5 micron, the optics remain limited by geometric aberrations, leading to diminishing returns on resolution. Traditional Image Signal Processors (ISPs) cannot eliminate these aberrations, because they operate through local, stage-wise processing with no explicit model of the underlying point spread function (PSF). We demonstrate how a learning-based Neural ISP for image restoration, trained on the underlying degradations, inverts what stage-wise pipelines cannot, turning small-pixel designs into a net advantage. We investigate this through a controlled simulation of a representative telephoto module, evaluating five configurations (0.35--0.75 micron pixel pitch). The aperture is scaled proportionally to keep per-pixel SNR and diffraction spot size fixed, thereby isolating geometric aberration and spatial sampling. While the traditional ISP improves only modestly with smaller pixels, the Neural ISP scales substantially: at 0.35 micron} it reaches 745 cycles/mm MTF50 (vertical), a 2.5--3x resolution improvement over the traditional ISP, and LPIPS improves significantly from 0.244 to 0.151 while traditional results stay comparatively flat. In a low-SNR extension (15 dB per-frame bursts at 0.35 micron), a multi-frame Neural ISP recovers performance close to the bright-light single-frame baseline, whereas a multi-frame traditional ISP shows no meaningful improvement -- indicating that traditional pipelines at small pixels are bottlenecked by uncorrected PSF blur rather than by noise. These results point to a design philosophy in which Neural ISPs enable high-resolution telephoto modules by correcting residual optical aberrations rather than requiring increasingly complex optics.

Noisy intermediate-scale quantum (NISQ) processors are entering an early fault-tolerance regime where full quantum error correction carries prohibitive resource costs, yet lightweight error detection can meaningfully improve algorithmic success rates. Existing compilation and error-detection toolchains treat these concerns in isolation, with no principled way to balance detection overhead against success probability under latency constraints. We present an integrated hardware-aware compilation and data-driven quantum error-detection (QED) framework that jointly optimises qubit mapping, SWAP insertion, and syndrome-schedule placement via a noise-weighted cost function and a learned multi-objective scheduler. Simulation experiments on an HPC cluster using GPU-accelerated density-matrix simulation (NVIDIA cuQuantum SDK) across VQE, phase-estimation, and Grover benchmarks, three noise profiles, and circuit sizes of 6-20 qubits (depths 10-160), show that joint co-design raises algorithmic success probability by up to 68 percent (95 percent CI: 60 percent to 76 percent) over SABRE on an 8-qubit VQE instance with post-selection.

Transformer inference increasingly depends on specialized compiler and runtime support, but real model graphs still require semantic decisions about which regions are worth specializing and which CUDA implementation families are plausible. We present AgentCompile, an LLM-guided CUDA inference compiler that uses LLM outputs only as advisory search metadata. Given compiler-derived region summaries and bounded candidate spaces, the LLM proposes semantic labels, candidate priorities, parameter hints, and risk annotations; the compiler materializes CUDA candidates through templates, checks interface and hardware constraints, validates candidates empirically, selects implementations by measured latency, and falls back when specialization is unsupported or unprofitable. In end-to-end autoregressive generation, AgentCompile averages 5.66x, 4.05x, and 4.26x speedup over PyTorch eager on Qwen3-1.7B, Qwen3-4B, and Llama-3.2-1B-Instruct, respectively, across five representative workloads. We will open-source the project.

Neuroevolution is a representative neural architecture search paradigm that evolves both network topology and weights through evolutionary algorithms. In this paper, we propose Seq103, a unified NEAT-style neuroevolution framework for compact sequence architecture discovery. Seq103 consists of a shared evolutionary backbone and an optional recurrent extension. The shared backbone includes an elementary node-and-connection representation, per-class RMSE-based evaluation, mutation-based evolution with class-wise recombination, and elitism. The optional hidden-state mechanism extends the search space with hidden-state nodes and hidden connections, enabling temporal memory when step-wise recurrent inference is required. With this design, Seq103 applies the same core search pipeline to both step-wise recurrent and sample-wise feedforward sequence classification. In recurrent tasks, the hidden-state extension is enabled to provide temporal memory; in feedforward tasks, it is disabled while the shared evolutionary backbone remains unchanged. We evaluate Seq103 on 8 text classification datasets and the full UCRArchive2018 benchmark with 128 univariate time-series datasets. On step-wise tasks, Seq103 retains 86.96% of the best-baseline accuracy on average while using 34.6x to 3218.0x fewer parameters. On sample-wise tasks over the full UCRArchive2018 benchmark, Seq103 retains 81.95% of the best-baseline accuracy on average while using 11.8x to 160,601.0x fewer parameters.