We address the problem of out-of-distribution (OOD) detection for target observations embedded in a subspace of the high dimensional data space. Using continuous normalizing flows (CNFs), we propose a Lagrangian sub-flow (LSF) framework designed to isolate and estimate the density for the relevant components in the representation and using the remaining components as context. Through experimentation with models for speech synthesis, we show that CNFs, similarly to other deep generative models (DGMs), are susceptible to the "likelihood paradox", where high likelihood is erroneously assigned to OOD samples. This is attributed to the inductive bias of DGMs that prioritize low-level structural details over high-level semantic coherence. To mitigate this phenomenon, we propose a number of geometric diagnostic signals based on the velocity field over the sub-flow trajectory. Based on these signals, we design metrics for the challenging task of zero-shot phoneme-level mispronunciation detection. Finally, we demonstrate the superiority of these metrics compared to likelihood-based methods on a real-world mispronunciation detection benchmark.

It has been proposed that the brain integrates flexible, computationally expensive cortical processing with simpler, lower-cost subcortical mechanisms to achieve resource-efficient performance greater than that of either system alone. Despite the allure of this perspective, satisfying theoretical frameworks that explore this hypothesis are still limited. We extend existing frameworks in which a model-based module and model-free module learn in tandem by explicitly constraining the memory resources of the model-based module, and investigate the impact of this constraint in a simple decision-making setting. Memory constraints naturally give rise to strategies for allocating memory resources. We evaluate the performance of different strategies in different situations and demonstrate that when the rewarded states change often, it can be advantageous for the model-based module to focus its memory resources not on exploiting the current reward, but on capturing general structure of the environment. This work provides a theoretical foundation for a functional dissociation between cortical and subcortical systems during learning: the cortex supports general structure learning, while subcortical circuits specialize in reward-based learning. We further detail how these hypotheses can be tested on experimental data.

Transition metal complexes are central to catalysis, drug design, and materials science, with relevant properties strongly sensitive to their three-dimensional geometry. However, the electronic diversity and unconventional bonding environments of transition metal complexes pose a major challenge for accurate structure generation. In this work, we introduce TMCgen, a manifold diffusion machine learning model that efficiently and accurately generates geometries of transition metal complexes. By formulating the diffusion process over the metal-ligand coordination angles, combined with torsional and rotational diffusion of the ligands, TMCgen focuses on the key geometric degrees of freedom of transition metal complexes. TMCgen shows strong performance in generating accurate coordination environments on a diverse set of experimentally derived bioinorganic and organometallic complexes while requiring only few inference steps, enabling efficient generation. Our results demonstrate the potential of manifold-based generative modeling for data-efficient geometry generation, paving the way for property-conditioned design of transition metal complexes.

We establish the finite-sample concentration rate for the Median-of-Incomplete-U-Statistics (MIU), an efficient robust estimator for the expectation of symmetric kernels.

The burgeoning field of LLM-based Multi-Agent Systems (MAS) promises to tackle complex tasks through collaborative intelligence, yet fundamental questions regarding their scaling behavior and intrinsic collective dynamics remain underexplored. This paper systematically investigates how the performance of a homogeneous MAS evolves as the number of agents increases, isolating the variable of collaboration from model or knowledge heterogeneity. We propose the Sequential Iterative Multi-Agent System (SIMAS) framework, a minimalist architecture centered on sequential inter-agent communication, to clearly observe scaling effects. Through extensive experiments across diverse tasks and model scales, we establish that MAS performance does not scale monotonically with agent count but follows a pattern of diminishing returns, governed by a trade-off between collaborative synergy and coordination overhead. Our findings reveal that effective MAS requires a sufficiently capable base LLM, that task type critically modulates the optimal agent count, and that collective intelligence is an emergent property contingent on strategic interaction design rather than a guaranteed outcome of agent plurality. The performance degradation stems coordination overhead rather than merely long-context failure, and the scaling tendency generalizes across interaction architectures like structured debate topologies. This work provides a foundational understanding of MAS scaling laws, offering practical guidance for designing efficient collaborative systems and challenging the prevailing assumption that more agents invariably lead to better performance.

Physics-Informed Neural Networks (PINNs) often train slowly or fail to converge on challenging partial differential equations (PDEs), a behavior recently linked to severely ill-conditioned loss landscapes inherited from the underlying differential operator. We study PINNs augmented with a pointwise data-fidelity term, added at a few points in the domain to the standard residual and boundary losses. We show that this supervision term acts as an operator-level preconditioner: for suitable weights, our comparison bounds guarantee a substantially smaller condition number than under the standard PINN loss, independently of how the pointwise labels are obtained. For a broad class of PDEs admitting a Feynman-Kac (FK) representation, we generate such labels by Monte Carlo averages of the FK functional, resulting in what we call ``FK-PINNs", and using the excess risk decomposition approach, we derive non-asymptotic $L^2(Ω)$-error bounds for FK-PINNs with $\tanh$ activation trained by finitely many steps of gradient descent. Along the way, we establish pseudo-dimension bounds for first- and second-order derivatives of $\tanh$ neural networks, which are of independent interest and, to the best of our knowledge, new. Numerical experiments on Poisson, Schrödinger, mean exit time, and committor problems corroborate the theory, and show that FK-PINNs can successfully solve PDEs for which standard PINNs exhibit severe failure modes.

This tech note describes the architecture and execution results of the LPDDR5X-PIM simulator, developed by Samsung Electronics. Based on the latest research and internal specifications, the simulator provides a high-fidelity model of both the hardware data paths and the software control layers of the LPDDR5X-PIM block. This integrated hardware-software simulation approach enables precise evaluation of system performance and energy efficiency while maximizing PIM resource utilization. We have refined existing simulation frameworks to align with actual hardware implementation, ensuring consistent behavioral accuracy. Further technical details regarding the specific architecture and circuit design of the LPDDR5X-PIM will be disclosed in future publications

Generative artificial intelligence has fundamentally changed how content is now produced. It has enabled how high-fidelity text, images, audio, and videos are created, modified, and redistributed at near-zero marginal cost. This shift exposes enterprises and ecosystems to a number of risks across four reinforcing authenticity layers -- authenticity, provenance, integrity, and accountability -- that traditional controls are inadequate to address in isolation. We introduce the concept of authenticity debt: the cumulative institutional liability that accumulates when organizations deploy AI-generated content without preserving verifiable origin, integrity, and accountability, deferring exposure that surfaces under regulatory, legal, or market scrutiny. This paper presents a comprehensive, multi-dimensional taxonomy of generative AI harms and attack vectors, surveys the capabilities and failure modes of technical controls including digital watermarking, provenance frameworks (C2PA, Adobe CAI), and detection technologies, and argues that no single mechanism is sufficient in open, adversarial, and evolving environments. Drawing on Zero Trust Architecture principles and enterprise governance frameworks, we propose a layered reference architecture that integrates cryptographic provenance, human-in-the-loop verification, and continuous governance to sustain defensible authenticity at scale. We further examine the regulatory landscape (EU AI Act, U.S.\ FTC, NIST AI RMF) and identify practical guiding principles for organizations seeking to build authenticity as institutional infrastructure rather than an afterthought.

Retrieval-Augmented Generation (RAG) has become an essential method for mitigating hallucinations in Large Language Models (LLMs) by leveraging external knowledge. Although effective for simple queries, traditional RAG struggles with large-scale, unstructured corpora where information is highly fragmented. Graph-based RAG (GraphRAG) incorporates knowledge graphs to capture structural relationships, enabling more comprehensive retrieval for complex reasoning. However, existing GraphRAG methods rely on isolated, fragment-level extraction for graph construction, lacking a global perspective on the whole corpus. As a result, these methods frequently lead to thematically inconsistent, logically conflicting, and structurally fragmented graphs that degrade retrieval performance. In this paper, we propose MemGraphRAG, a novel framework that introduces a memory-based multi-agent system to ensure high-quality graph construction. Specifically, MemGraphRAG employs a collaborative society of agents supported by shared memory, which provides a unified global context throughout the extraction process. This mechanism allows agents to dynamically resolve logical conflicts and maintain structural connectivity throughout the corpus. Furthermore, we propose a memory-aware hierarchical retrieval algorithm tailored for the constructed graph. Extensive experiments on multiple benchmarks demonstrate that MemGraphRAG outperforms the state-of-the-art baseline models with comparable efficiency. Our code is available at https://github.com/XMUDeepLIT/MemGraphRAG.

Agentic search systems iteratively interact with retrieval models to answer complex queries. Despite substantial progress, optimizing retrievers for agentic search remains challenging, often requiring heavy co-training or gold-standard annotations that limit real-world applicability. We propose Critic-R, a framework that explicitly closes the feedback loop between the reasoning agent and the retrieval model during both inference and training. Critic-R introduces a critic model that evaluates the agent's introspective reasoning trace after consuming retrieved evidence to determine whether the retrieved context sufficiently supports the next reasoning step. Critic-R has two complementary mechanisms: Critic-R-Zero, an inference-time query refinement loop that iteratively rewrites queries and retrieval instructions, and Critic-Embed, an optimization approach for retrieval models that leverages successful and failed refinement trajectories as automatic supervision without requiring manual relevance annotation. We evaluate Critic-R on HotpotQA, 2WikiMultihopQA, MuSiQue, and Bamboogle. Results show that Critic-R significantly improves both retrieval quality and downstream answer accuracy.

This paper proposes Spectra-Guided Neural Tucker Factorization (SG-NTF) for High-Dimensional and Incomplete (HDI) tensor completion. Circumventing discrete representational limits, SG-NTF maps scalar timestamps into a continuous spectral space to abstract temporal periodicities. Concurrently, a Spatio-Temporal Co-Gating (STCG) mechanism explicitly filters latent interactions via multiplicative modulation on spatiotemporal contexts. Evaluations on real-world HDI tensors verify that SG-NTF maintains competitive completion accuracy with parameter efficiency.

Multi-robot systems (MRS) increasingly offload compute-intensive perception tasks to edge nodes to meet strict time-sensitive Quality-of-Service (QoS) constraints. However, static task orchestration on a shared edge node can severely degrade QoS due to network latency, jitter, and edge-resource contention. We present a pilot edge-centric MRS testbed using Raspberry Pi nodes to evaluate a camera-to-manipulator pipeline under three modes: local execution, static offloading, and a QoS-aware Adaptive Task Placement (ATP) controller. ATP scores candidate placements using a multi-metric cost (normalized latency, CPU utilization, and switching overhead) over two-second control windows. The closed-loop visual servoing testbed is instrumented with sub-millisecond clock synchronization, network emulation, and detailed monitoring of multiple metrics across nodes to capture realistic jitter. Experimental results under compute-stress and network-fault scenarios show that static edge offloading reduces on-board CPU load but amplifies tail latency and deadline misses. In contrast, the QoS-aware ATP controller, by switching task placement based on measured latency and utilization thresholds, consistently lowers deadline violations and tail latency. Overall, the results position ATP as a practical edge-side control primitive for MRS and concrete design guidelines for Cloud-Edge Robotics deployments within the broader cloud-fog automation, while motivating QoS-aware multi-objective workload orchestration for industrial cyber-physical systems.

The persistent challenge in scaling authentic manipulator education within university laboratories is a structural dichotomy: commercial digital twins are often cost-prohibitive and rigidly scripted, whereas open-source robotics middleware (ROS) imposes steep technical and syntax barriers for novices. To resolve this logistical and educational friction, this Work-in-Progress (WiP) paper proposes a scalable four-tier communication architecture tailored for sustainable robotic curricula. Rather than focusing on software application design, our study examines the underlying data exchange mechanisms required to bridge visual conceptual environments with physical robotic endpoints, utilizing the Graphical Open-Source Platform (GOSP) as a foundational instantiation. This WiP details the framework's technical integration of 3D visual armature modeling with a robust ROS middleware backend, emphasizing the serialization, routing, and encapsulation of intricate communication routines. Preliminary sim-to-real validation using multi-axis spatial trajectories confirms that encapsulating these communication pipelines provides a sufficient fidelity hardware-agnostic pathway. By bridging virtual design and physical execution, this architectural blueprint offers a viable infrastructure for engineering education.

Many stochastic gradient methods are believed not to converge when the noise in stochastic gradients has only a finite $p$-th moment for $p\in\left(1,2\right)$, a setting known as the heavy-tailed noise assumption. However, some recent studies have found that Stochastic Gradient Descent ($\textsf{SGD}$), without any modification to its update rule, can surprisingly converge in expectation for convex problems with bounded domains, highlighting the potential of classical stochastic gradient methods. Inspired by this recent progress, we provide a comprehensive study of stochastic optimization under heavy-tailed noise and establish new in-expectation convergence results for Stochastic Mirror Descent ($\textsf{SMD}$) and Accelerated Stochastic Mirror Descent ($\textsf{ASMD}$) in convex optimization, and for $\textsf{SGD}$ and Stochastic Gradient Descent with Momentum ($\textsf{SGDM}$) in nonconvex optimization. Notably, our results not only hold without algorithmic changes but also avoid restrictive assumptions, such as bounded domains, imposed in prior work. More importantly, our analysis provides a new, elegant, and powerful framework for studying heavy-tailed stochastic optimization, opening a new route to understanding first-order stochastic gradient methods.

We present a simple and efficient algorithm for robust approximate message passing (AMP) in the spiked matrix setting. In particular, let $\varepsilon$ be a sufficiently small constant, and suppose that $X \in \mathbb R^{n \times n}$ is a Gaussian matrix with a planted rank-$1$ spike, and $E \in \mathbb R^{n \times n}$ is an adversarially chosen matrix supported on an $\varepsilon n \times \varepsilon n$ principal minor. Let $v_{\mathrm{AMP}}(X)$ be the output of an AMP iteration on the uncorrupted matrix $X$. We give a procedure that, given access only to the corrupted matrix $Y = X + E$, computes a vector $v_{\mathrm{ALG}}(Y)$ which is $\tilde{O}(\sqrt{\varepsilon})$-close to $v_{\mathrm{AMP}}(X)$, for any of a class of AMP iterations which includes sparse Principal Component Analysis (PCA), non-negative PCA, and $\mathbb Z_2$ synchronization. Our algorithm consists of a spectral pre-processing step combined with a robust spectral initialization procedure; given these inputs, we prove that (perhaps surprisingly) AMP is robust out-of-the-box.

Deceptive web content, widely instantiated across the internet and commonly known as \textit{social-engineering attacks}, manipulates autonomous web agents into submitting users' personally identifiable information (PII) to attacker-controlled endpoints. In this paper, we show that social-engineering attacks are highly effective at extracting critical-tier PII from frontier web agents, posing a severe risk to deployed agentic systems. To quantify this risk, we introduce \textbf{\textsc{Scammer4U}}, a pre-registered benchmark of 91 attacker-controlled environments and 10 benign-twin baselines, spanning 8 attack vectors and 16 site categories on an 8-axis factorial taxonomy that isolates the causal contribution of individual attack design factors. Across frontier agents, we find that critical-tier PII leakage reaches 54--93\% under no privacy guidance, compared to 0\% on benign-twin baselines, confirming that leakage is attack-attributable rather than incidental form-filling. Escalating prompt-level mitigation yields sharply model-dependent reductions across the four families and remains insufficient to reliably prevent critical PII submission at the pooled level. Most critically, we identify a detection--action gap: agents whose reasoning an independent LLM judge confirms has flagged the site as suspicious still submit critical PII in 35.9\% of sessions, versus 66.1\% when no suspicion is verbalized, a 30.2\% gap robust across all four model families. Our findings reveal that defenses conditioned on the agent's own recognition of an attack are gating on the wrong signal, motivating output-level interception of outbound submissions that operates independently of the agent's reasoning loop.

Genotype-based cis-expression prediction depends on accurately modeling local regulatory architecture. We present block-sparse Bayesian sparse linear mixed model (bsBSLMM), an extension of Bayesian sparse linear mixed model (BSLMM) that incorporates linkage disequilibrium (LD)-block spike-and-slab sparsity and a transcription start site (TSS)-informed SNP inclusion prior. Across 23,098 genes from GEUVADIS European-ancestry lymphoblastoid cell lines, bsBSLMM retained more predictable genes than BSLMM, LASSO, BLUP, TIGAR elastic net, and TIGAR Dirichlet-process regression under matched evaluation criteria. Compared with BSLMM, bsBSLMM improved held-out prediction performance for most shared genes, with gains driven primarily by LD-block sparsity and further enhanced by the TSS-informed prior. Variants selected by bsBSLMM showed stronger enrichment in GM12878 DNase and H3K27ac regulatory regions than variants selected by BSLMM. In transcriptome-wide association study (TWAS) analysis, bsBSLMM recovered established inflammatory bowel disease signals, including IL23R, and identified additional genome-wide significant genes not detected by BSLMM. Independent validation in the Louisiana Osteoporosis Study reproduced the increased prediction yield across ancestries and recovered biologically relevant bone mineral density pathways in downstream TWAS and gene set enrichment analyses. These results demonstrate that incorporating LD-block structure and biologically informed SNP priors improves cis-expression prediction and enhances downstream TWAS discovery.

LLM agents increasingly rely on community-contributed skills that expand an agent's operational capability set. We study a core safety problem in agentic AI systems: whether individually safe skills can compose into unsafe installed skill sets. We present SkillReact, a compositional security measurement framework with three components: a deterministic static-composition benchmark, a two-rater LLM-assisted human-adjudication pipeline, and an action-based exploitability harness. On 1,520 ClawHub skills, 651 pass individual inspection and form 211,575 pairs; the benchmark flags 22.25% of these as structural candidates. We treat this raw rate as a recall-oriented scanner ceiling and calibrate it against human judgment: in a pattern-stratified audit, roughly one in five flagged pair-pattern hits survives as a real compositional risk (population-weighted validity 18.2%, our headline result), implying about 14K genuine risk memberships in a single registry that per-skill scanning misses by construction, since every pair is individually safe. An action-based harness then probes when these candidates become model-issued tool calls, and finds realization gated by host-model disposition: on an anchor-conditioned dropper subset, Haiku-4-5 issues the dropper-stage tool call on all 39 direct-prompt trials (36 of them the full download-then-execute chain, 3 download-only), Opus-4-7 stops at the download, and Sonnet-4-6 refuses outright. A control that holds the request fixed and varies only the installed skills finds compliance highest with no skills installed: a composition fixes which capabilities are reachable, while the host model decides whether to use them. Together these motivate install-time compositional checks and capability isolation as complements to per-skill scanning.

Modern recommendation systems predominantly train retrieval and ranking as separate models despite both increasingly relying on large transformers encoding the same user behavior data, duplicating parameters, compute, and serving cost. Prior work unifies the model architecture but not the full pipeline: input formats, training procedures, and serving stacks remain fragmented across stages. We present UniPinRec, which achieves full-stack unification of retrieval and ranking at Pinterest: one input format, one model, one training stage, deployed within existing serving infrastructure. A shared transformer encodes the user action sequence into candidate-independent representations that branch into retrieval (ANN dot-product) and ranking (cross-attention) via task-specific heads. Three ideas make this work: (1) Masked Action Modeling (MAM) eliminates interleaving, enabling weight sharing without doubling context length; (2) Blended training examples pair action sequences with feedview impression slates to satisfy both objectives jointly; (3) Cross-stage KV cache sharing reuses user-history computation from retrieval for ranking, reducing total FLOPs versus serving two independent models. Deployed in the Pinterest core surfaces, UniPinRec delivers approximately +1% online engagement lift while cutting end-to-end serving latency by 11.1% and lifting QPS by 63.6%. To our knowledge, this is the first full-stack unification of retrieval and ranking, covering inputs, model, training and serving, deployed in a production recommendation system.

To meet the stringent requirements of emerging applications and the increasingly complex network management and operation, the Next Generation Mobile Networks (NextG), or 6G, will adopt an AI-native architecture on the Core Network (CN). In this movement, the Third Generation Partnership Project (3GPP) has extended the cellular CN with new function as a first step toward integrating analytics, Artificial Intelligence (AI), and machine learning. However, those new functionalities are constrained by a centralized approach and managerial complexity. Furthermore, with the rise of Large Language Models (LLMs), a new era in network orchestration and management begins, leveraging and empowering the Intent-based Networking (IBN) paradigm. In addition, AI agents and Agentic AI integrate Reasoning and Acting (ReAct), enabling the usage of such intents to continuously interact with the network. Unlike state-of-the-art approaches that primarily employ Agentic AI to mitigate deployment and configuration complexity in the CN, this paper introduces AgentxGCore, which leverages an Agentic AI-Native layer to extend the 3GPP architecture and enable a system based on the existing APIs across the Beyond Next Generation Core (xGC) domain. This proposal establishes an AI-driven closed-loop for continuous optimization based on real-time information, enabling self-organization and self-adaptation. Our approach involves a multi-agent specialized system, divided into a network planner agent, capable of visualizing the network state and developing a plan to meet the intents, and a network executor, responsible for criticizing and executing the plan. To validate the proposed solution, an environment was built using an open-source CN, heterogeneous datasets, and different LLMs were employed to demonstrate its effectiveness.

Sufficient dimension reduction (SDR) makes high-dimensional regression tractable by projecting the covariates onto a low-dimensional subspace that preserves the conditional mean of the response. Existing gradient-based estimators either operate in the ambient space and suffer from the curse of dimensionality, or localize in the reduced space at a per-outer-iteration cost at least quadratic in the sample size. We show that minimizers of the population Minimum Average Variance Estimation (MAVE) risk approximate the same Grassmannian target as the Outer Product of Gradients (OPG), and recast the empirical criterion as a smooth maximization on the Stiefel manifold with closed-form Riemannian gradient. The resulting algorithm, SMAVE, combines sparse projected-space nearest-neighbor localization with Riemannian stochastic gradient ascent. A simplified version comes with almost-sure convergence and a non-asymptotic rate matching the standard non-convex stochastic first-order scaling. Empirically, SMAVE matches or improves on RMAVE's synthetic subspace recovery at moderate-to-high ambient dimension, and on four real datasets it uniformly improves over OPG and is competitive with or outperforms RMAVE at orders of magnitude lower runtime.

We propose a distribution-free statistical framework that converts arbitrary rewrite-based detectors into detectors with finite-sample FDR guarantees without retraining. Our key observation is that rewrite-based detection implicitly constructs knockoff samples, enabling LLM-generated text detection to be formulated as a multiple hypothesis testing problem with knockoff structure. This perspective separates the design of detection statistics from the control of false discoveries, allowing existing rewrite detectors to inherit finite-sample false discovery rate (FDR) guarantees through a simple calibration procedure. We demonstrate reliable FDR control with meaningful detection power across three detection models, 19 domains, and four LLMs.

Simulating large molecular systems comprising thousands of atoms requires highly scalable methodologies. While modern Density Functional Theory (DFT) codes exhibit linear scaling, solving the associated large, sparse generalized eigenproblems remains a critical computational bottleneck on exascale architectures. In the context of the LimitX project, we propose a data-driven framework to accelerate these calculations. By shifting the machine learning target from discrete eigenvalues to the coefficients of an interpolating Chebyshev polynomial, and by comparing both all-atom and fragment-based structural representations, we successfully overcome the dimensionality constraints of large-scale spectral prediction. We investigate three machine learning models (Kernel Ridge Regression, Graph Neural Networks, and Random Forests) trained on a novel 2 TB dataset of protein dimers. The predicted spectra provide initial guesses that effectively bypass early Self-Consistent Field (SCF) iterations in BigDFT. Ultimately, these spectral predictors will be deployed to dynamically optimize upcoming rational filter-based eigensolvers, such as FrASE, which is currently in initial development.

Geometric distortion in prostate diffusion-weighted imaging (DWI) can impair lesion localization and reduce the reliability of MRI-based clinical assessment. We propose AutoIQ, an ensemble machine learning framework for automatic quantification and classification of DWI geometric distortion severity. A total of 140 retrospective prostate biparametric MRI examinations were analyzed, including 33 scans with severe distortion requiring repeat acquisition and 107 scans with acceptable distortion based on expert radiologist assessment. AutoIQ combines two complementary distortion quantification strategies: a segmentation-based method measuring prostate boundary mismatch between T2-weighted imaging (T2WI) and DWI, and a registration-based method estimating deformation magnitude after DWI-to-T2WI alignment. The resulting distortion scores were used to train individual classifiers and a logistic-regression ensemble model. Both computational methods significantly differentiated severe from acceptable distortion cases (p < 0.001). On an independent test set, the ensemble model achieved an accuracy of 0.95, F1-score of 0.93, and AUC of 0.98, outperforming individual models. These results suggest that AutoIQ can provide automated, quantitative quality assessment for prostate DWI and may help identify scans that require repeat acquisition.

Diverse genomics data, scientific questions, and analysis tasks typically demand highly specialized visualizations. Therefore, users often must customize or author new ones tailored to their data. Existing tools are usually either limited in customization or require substantial learning or programming, and even expressive tools assume visualization expertise many users lack. Agentic and large language model (LLM) approaches are increasingly applied to complex scientific tasks, including visualization. Natural-language conversational interfaces offer a promising path to democratizing the authoring of complex visualizations. In the context of genomics, these approaches face additional challenges: genomics visualizations typically integrate heterogeneous data types and are composed of multiple linked interactive views. These challenges motivate more structured LLM-based schemes. We first characterize where vanilla LLM generation succeeds and fails for genomics visualization, identifying eight quality dimensions. We then compare six schemes--direct generation, a fixed pipeline, and four agentic configurations varying in the number of specialist agents and the presence of a reviewer--across 159 cases spanning three levels of query ambiguity and specification complexity. All schemes use the Gosling visualization grammar as structured output. Agentic iteration substantially improves perceived quality over both baselines, while more complex agent architectures yield no additional benefit. We discuss implications for designing agentic systems for domain-specific visualization authoring. All supplemental materials are available at https://osf.io/uqe83.

Safe global deployment of AI models requires alignment with human values that vary across cultures. Yet rater pools in safety evaluation datasets remain largely geographically homogeneous, failing to capture geo-cultural differences. Further, it remains unclear whether such differences persist after controlling for demographics such as age, gender, and ethnicity. Through a meta-analysis of safety datasets, we find that most do not report geo-cultural information, and those that do lack a unified methodology to jointly analyze geo-cultural and demographic correlates. Using the Inglehart-Welzel dimensions of cross-cultural variation, we demonstrate via multilevel modeling that cultural zone membership explains variance in safety ratings beyond standard demographics (p<0.05 across 6 datasets). Moreover, our analysis indicates that roughly 10% of items in the datasets we examined are culturally sensitive: likely to be misclassified as safe without adequate cultural representation. We evaluate LLMs as both rater surrogates and triage tools, finding that current LLMs do not reliably stand in for raters, though they can help prioritize culturally sensitive items for human annotation. Our findings motivate more culturally pluralistic safety evaluation and offer practical takeaways to support it.

Recursive systems can enter collapse-like regimes -- self-reinforcing amplification, persistent recursion, and narrowing diversity that mask accelerating internal degradation -- before overt failure becomes visible. We introduce Loopzero, a claim-bounded benchmark framework for testing whether recursive failures follow a directional telemetry pattern: rising gain (G), recursive persistence (p), and declining diversity ($δ$). The claim boundary is specified in Lean; the Lean artifact does not verify real telemetry, benchmark validity, or detector performance. We evaluate the bridge on two frozen public-artifact benchmarks: a segmented public-markets benchmark (Volmageddon 2018, COVID MWCB 2020) and a MovieLens-25M offline deterministic recommender replay. Detectors are evaluated under a locked equal-false-positive contract (FP $\in$ [0.03, 0.07], pre-registered) so all configurations face the same alert budget. Neither tested standard comparators nor Loopzero's pre-registered quantile detector achieved an accepted operating point. Directional witness alignment held on both canonical benchmarks, with adjacent-horizon and row-level limitations disclosed. Digitized Shumailov et al. (2024) LLM training-loop trajectories are directionally consistent with the pattern; matched-FP evaluation in that domain is deferred. The contribution is a reproducible, falsifiable benchmark framework for evaluating recursive-collapse warning claims under an explicit alert-budget contract -- non-acceptance reported as a first-class scientific outcome.

Clustering is widely used across the sciences as the foundation for downstream data-driven scientific discoveries. However, clustering results are highly sensitive to the choice of algorithm, preprocessing, and the number of clusters $k$, producing scientific claims that are often not reproducible. The current state of the art for validating clustering solutions consists of clustering validation indices (CVIs) such as Silhouette, Davies-Bouldin, and Calinski-Harabasz, which rely on geometric assumptions that break down on the heavy-tailed, high-dimensional, and nonlinearly structured data encountered in biomedical research. Resampling-based alternatives - grounded in the ideas of clustering stability and generalizability - have been proposed but remain scattered across specialized tools with no unified, accessible software. We fill this gap with CARVE (Cluster Analysis with Resampling for Validation and Exploration), an open-source Python and R package that jointly evaluates multiple clustering algorithms and hyperparameters, returning stability and generalizability diagnostics at the global, cluster, and sample level together with principled selection rules and consensus-based cluster labels. Across six synthetic benchmarks CARVE consistently recovers near-optimal clusterings where classical indices degrade substantially. On experimental genomics and proteomics data sets, CARVE recovers finer biological structure when classical CVIs collapse entirely. CARVE is available with a scikit-learn-compatible Python API and an analogous R interface compatible with Seurat workflows.

Multimodal LLMs use dedicated encoders to bridge non-language modalities (vision encoders for images, depth models for audio codec tokens) because raw token embeddings alone cannot capture modality-specific structure. We argue that Semantic IDs (SIDs), the hierarchical codes used in generative recommendation, constitute another such modality: a SID level token's meaning depends on its prefix context, yet current systems simply add SID tokens to the vocabulary and rely on training to learn these context-dependent meanings from scratch. We propose PrefixMem, a lightweight SID encoder based on prefix n-gram memory tables that provides the LLM with structured, prefix-conditioned representations at SID token positions. Like vision encoders in multimodal LLMs, PrefixMem can be pre-trained independently and then attached to any LLM for joint training. We evaluate on large-scale data from Pinterest across multiple LLM families and show that PrefixMem improves deepest-level SID accuracy by up to 46% relative and full-SID retrieval recall by up to 22% relative at matched training compute. The encoder's benefit concentrates on hard examples where greedy decoding fails, with up to 77% relative accuracy gains, confirming that SID tokens benefit from a dedicated encoder just as other non-language modalities do.

Over the past half-dozen years, stochastic rounding (SR) has regained significant attention as a quantization scheme for low-precision floating-point arithmetic, with applications spanning numerical analysis and modern machine learning systems. Recent work has shown that SR acts as an implicit regularizer by increasing the smallest singular value of extremely tall-and-thin (or, symmetrically, short-and-fat) matrices. In this work, we substantially sharpen and extend this understanding in two directions. First, we show that the regularization effect of SR is not restricted to extreme aspect ratio regimes: it persists for matrices with constant aspect ratio. Second, we demonstrate that SR does not merely regularize the smallest singular value, but instead lifts entire clusters of singular values at the tail of the spectrum. Together, these results provide a more general characterization of stochastic rounding as a spectral regularizer, revealing that its effects extend beyond extremal aspect ratios and act on a broader portion of the singular value spectrum.