In neuroscience, numerous studies conduct sensory or behavioral experiments under multiple conditions to acquire neural responses in the form of high-dimensional spike train datasets. Analyzing high-dimensional spike data is a challenging statistical problem. To this end, Gaussian process factor analysis (GPFA), a popular class of latent variable models, has been proposed for data collected under a single experimental condition. GPFA extracts smooth, low-dimensional latent trajectories that summarize highdimensional spike datasets. However, standard GPFA infers these trajectories independently for each experimental condition, not accounting for how the underlying activity varies across the condition space. This poses limitations on both accuracy and the interpretability of the latent representation. To address these limitations, we propose Coupled Subspaces GPFA (CS-GPFA), a Bayesian model that jointly learns latent representations, characterizing how the neural activity varies over the condition space. Building on this, we further develop an active-learning algorithm for adaptively selecting conditions. Experiments on both synthetic and real neural datasets demonstrate that CS-GPFA achieves superior performance compared to existing approaches. Moreover, our active learning results show that CS-GPFA can efficiently guide experiment design in practical settings.

Multimodal learning aims to preserve as much task-related information as possible from different inputs. However, current fusion designs often distort the feedback loop to feature extractors. Aggressively merging modalities entangles their representations, making the feature extractors fragile to incomplete inputs. Meanwhile, attempting to separate features via auxiliary losses frequently introduces optimization conflicts that distract from the primary task. We propose the Self-Consistent Field Autoencoder (SCFAE) to provide a better path for task gradients. Our method follows the self-consistent field principle to balance task learning with feature organization, thereby minimizing mutual information. We use small autoencoders for each modality to keep information intact. The task loss acts as a driving force to select predictive features. The reconstruction loss acts as a constraint to separate these features into independent subspaces. These dual objectives operate through complementary feature subspaces, thereby mitigating optimization interference. We evaluate SCFAE on audio-visual-text, audio-visual, and image-video benchmarks. Results show that SCFAE handles missing data and unequal input sizes more robustly via a simple structure. Gradient analysis confirms that SCFAE avoids conflicts and maintains stable training dynamics.

Graphs play an important role in representing complex relationships in various domains like social networks, knowledge graphs, and molecular discovery. With the advent of deep learning, Graph Neural Networks (GNNs) have emerged as a cornerstone in Graph Machine Learning (Graph ML), facilitating the representation and processing of graphs. Recently, LLMs have demonstrated unprecedented capabilities in language tasks and are widely adopted in a variety of applications such as computer vision and recommender systems. This remarkable success has also attracted interest in applying LLMs to the graph domain. Increasing efforts have been made to explore the potential of LLMs in advancing Graph ML's generalization, transferability, and few-shot learning ability. Meanwhile, graphs, especially knowledge graphs, are rich in reliable factual knowledge, which can be utilized to enhance the reasoning capabilities of LLMs and potentially alleviate their limitations such as hallucinations and the lack of explainability. Given the rapid progress of this research direction, a systematic review summarizing the latest advancements for Graph ML in the era of LLMs is necessary to provide an in-depth understanding to researchers and practitioners. Therefore, in this survey, we first review the recent developments in Graph ML. We then explore how LLMs can be utilized to enhance the quality of graph features, alleviate the reliance on labeled data, and address challenges such as graph Heterophily and out-of-distribution (OOD) generalization. Afterward, we delve into how graphs can enhance LLMs, highlighting their abilities to enhance LLM pre-training and inference. Furthermore, we investigate various applications and discuss the potential future directions in this promising field.

Meta-learning empowers learning systems with the ability to acquire knowledge from multiple tasks, enabling faster adaptation and generalization to new tasks. This review provides a comprehensive technical overview of meta-learning, emphasizing its importance in real-world applications where data may be scarce or expensive to obtain. The paper covers the state-of-the-art meta-learning approaches and explores the relationship between meta-learning and multi-task learning, transfer learning, domain adaptation and generalization, self-supervised learning, personalized federated learning, and continual learning. By highlighting the synergies between these topics and the field of meta-learning, the paper demonstrates how advancements in one area can benefit the field as a whole, while avoiding unnecessary duplication of efforts. Additionally, the paper delves into advanced meta-learning topics such as learning from complex multi-modal task distributions, unsupervised meta-learning, learning to efficiently adapt to data distribution shifts, and continual meta-learning. Lastly, the paper highlights open problems and challenges for future research in the field. By synthesizing the latest research developments, this paper provides a thorough understanding of meta-learning and its potential impact on various machine learning applications. We believe that this technical overview will contribute to the advancement of meta-learning and its practical implications in addressing real-world problems.

Language models can find thousands of severe software vulnerabilities, and agents are increasingly being misused for cyberattacks. To avoid detection, attackers frequently distribute their misuse, splitting a harmful task across many user accounts so each individual transcript looks benign. Because safety monitors score only one agent context at a time, they are structurally blind to misuse that is only visible in aggregate, across many accounts. We show this gap is real by building, to our knowledge, the first distributed agent attack, a multi-agent scaffold that completes hard cybersecurity tasks while hiding the harmful objective across subagents with limited contexts, evading a standard monitor that catches it only a fifth as often as prior agent attacks. Towards a defense, we develop an online stateful monitor that uses real-time clustering to collect weak suspiciousness signals across many agent transcripts, and escalates only rarely to a language model that flags misuse across user accounts. In evaluations with large-scale simulated datacenter traffic, our monitor Pareto dominates standard monitors, catching distributed attacks 30% earlier and flagging cyber misuse before it reaches the most harmful stages. Crucially, this comes at negligible additional latency for ~99% of user traffic. This detection advantage persists but narrows as the benign background traffic grows very large. After an extensive red-teaming exercise, we improve the defense and surprisingly also find that it catches standard jailbreaks, since adaptive attackers reuse attack variants across accounts. Our results point toward a new class of safety monitors which reason over groups of users rather than isolated transcripts.

Scalable information retrieval testing needs corpora that are large enough to stress index construction, ranking latency, query routing, and evaluation tooling, yet human-judged test collections remain expensive and may be unavailable when documents are private or still under design. This paper introduces SPECTRA, a reproducible framework for generating synthetic text corpora and retrieval test collections through a separation of latent topical structure, surface text realization, metadata controls, query intent generation, and deterministic relevance oracles. The framework is intended as a diagnostic complement to Cranfield-style and TREC-style evaluation, not as a replacement for human assessment. A single-process Python prototype generated corpora up to 60,000 documents and 9.61 million tokens while preserving controllable long-tail vocabulary growth and producing graded relevance labels for 96 queries. In the local simulation study, generation remained close to linear at roughly 12K to 14K documents per second, estimated Zipf slopes stayed near 0.86 in absolute value, and increasing cross-topic distractor text reduced BM25 nDCG@10 from 1.00 at 2% distractors to 0.43 at 36% distractors. These results show that lightweight synthetic corpora can expose retrieval-system scaling and failure modes before costly collection construction begins.

Constitutive laws for inelastic materials must satisfy strict thermodynamic admissibility requirements, yet current data-driven approaches sacrifice interpretability, even when formal guarantees are provided by physics-encoded architectures. We propose a symbolic regression framework for the data-driven discovery of dissipation potentials governing the evolution of internal variables within the Generalized Standard Materials (GSM) formalism. Starting from the Clausius--Duhem inequality, we enforce the thermodynamic requirements, convexity and non-negativity, that the dual dissipation potential must satisfy to guarantee non-negative mechanical dissipation. These requirements are formulated in the general subdifferential setting, encompassing rate-dependent (viscoelastic) and viscoplastic dissipative mechanisms, including potentials with genuine elastic domains, within a unified framework. Candidate potentials are generated by a composition-extended convexity-preserving grammar that guarantees thermodynamic admissibility \emph{by construction}. The framework is validated on synthetic datasets spanning Newtonian, power-law, and Bingham viscoplastic ground truths under process and measurement noise, and on experimental oscillatory shear measurements of a synthetic elastomer across multiple strain amplitudes and frequencies, where the discovered potentials reproduce the amplitude-dependent softening of the dynamic moduli and outperform a calibrated linear Zener baseline.

Credential leakage in public source code repositories poses a critical security threat, with over 23.8 million secrets exposed in 2024 alone. Existing detection tools suffer from high false-positive rates because rigid pattern matching and binary classification schemes fail to distinguish genuine credentials from placeholder or weak credentials. We propose a three-class classification framework that explicitly models placeholder or weak credentials as a distinct class, leveraging CodeBERT-based semantic understanding combined with character-level pattern recognition. We evaluate our approach on a newly constructed dataset of 9,426 samples spanning 10 programming languages. Our model achieves a Matthews Correlation Coefficient of 0.86 and a macro F1-score of 0.90, achieving 93% recall and 89% precision for genuine credential leaks while reducing high severity alerts by 33.0% (from 373 to 250) without sacrificing security coverage. Compared to prior character-level approaches, our method improves placeholder or weak credential detection from 54% to 81% F1-score while maintaining strong cross language generalization, with 9 of 10 languages achieving F1 above 0.80 under leave-one-language-out evaluation.

Large language models (LLMs) are increasingly used to automate power-system analysis, but many utilities and energy-research labs require on-premise serving for confidentiality, regulatory, reproducibility, and cost reasons. This makes the reliability of open-weight models a deployment issue. We show that first-pass failures in power-system code generation are dominated not by reasoning alone, but by structured API-knowledge boundary errors: hallucinated function names, misused parameters, and mishandled result tables in versioned simulation libraries. We introduce PowerCodeBench, an execution-validated benchmark generator that pairs natural-language operator queries with pandapower code and numerical ground truth; an L0-L3 documentation-driven probing procedure that measures per-model API knowledge profiles; and a boundary-aware intervention that combines query-side API demand estimation with targeted proactive documentation injection and routed reactive correction. On a 2,000-task frozen release, we evaluate ten open-weight LLMs (1.5B-480B parameters) and four commercial mid-tier APIs. The intervention improves every evaluated open-weight model of at least 7B parameters and every commercial API by 32 to 56 accuracy points. Open-weight models in the 70B-120B range match the commercial mid-tier accuracy range, while Llama-3.1-405B and Qwen3-Coder-480B lead the panel. The targeted prompts preserve the full-context accuracy ceiling while using 41% of the prompt-token cost. The result is an accuracy-side, deployment-time path toward reliable on-premise LLM assistance for grid-analysis workflows without fine-tuning or cloud inference.

In this work we study agents in simulated bargaining scenarios, where a buyer and a seller communicate through a text channel and attempt to negotiate mutually beneficial trades, under different information regimes (complete information, information asymmetry or mutual uncertainty). We evaluate their performance w.r.t. game-theoretical solutions and further investigate their honesty (their tendency to disclose or withhold information or to mislead and deceive) as well as their credulity (their tendency to trust or distrust information provided by the other agent). We study zero-shot LLM agents with simple prompting scaffolding as well as fine-tuned agents, in order to investigate whether optimising the agents to maximise financial profits makes them stronger negotiators but also more dishonest and less trusting. We find that off-the-shelf LLMs all substantially deviate from game-theoretical equilibria, they attempt to lie about their private information but cannot efficiently exploit information asymmetries. Fine-tuning on financial utility makes the agents stronger at achieving better deals but also more dishonest, highlighting the risks that optimising agents for a task can have on their safety. We release our code and a dataset of bargaining scenarios.

We present a regression-adjustment framework designed for the estimation of longitudinal treatment effects in randomized experiments under static regimes. While regression-adjustment methods are useful for variance reduction in randomized experiments by using pre-treatment covariates, they usually focus only on average effects, from which we cannot obtain valuable insights into when the effects appear and how long they continue. To address this issue, we consider intermediate outcomes and evolving post-treatment covariates over time, and we represent such dynamic trajectories using transition kernels. Furthermore, we establish the asymptotic normality and the semiparametric efficiency bound for our estimator, enabling more powerful statistical inference. Simulation studies and empirical analysis using A/B test data from a streaming platform in Japan show the practical advantages of our method.

Image Scanning Microscopy (ISM) is a fluorescence imaging technique that combines detector-array acquisition and computational reconstruction to achieve the theoretical resolution of an ideal confocal microscope, i.e., one operating with an infinitesimally small pinhole, while maintaining high signal-to-noise ratio. Among the reconstruction methods for obtaining the super-resolved image, multi-image deconvolution (MID) and its extension aimed at preserving the optical sectioning capability of confocal microscopy, known as super-resolution sectioning ISM (s$^2$ISM), are among the most widely used approaches. Both methods rely on Richardson--Lucy-type iterative schemes, whose semi-convergent behavior requires early stopping and often leads to noise amplification and reconstruction artifacts. In this work, we introduce a self-tuning explicit regularization framework for both MID and s$^2$ISM reconstruction. Within a Bayesian maximum a posteriori formulation, we combine a multi-frame Poisson data fidelity term with explicit regularization, considering $\ell_1$ and smoothed total variation penalties as representative examples. We further develop an automatic and ground-truth-free strategy for regularization parameter selection by adapting the residual whiteness principle to the multi-frame Poisson setting and introducing a spectral high-pass extension tailored to s$^2$ISM. The resulting framework enables stable reconstructions without empirical stopping rules. To demonstrate the proposed framework, we consider first-order optimization schemes based on proximal gradient and mirror descent methods with adaptive backtracking strategies. Experiments on simulated and real fluorescence ISM datasets demonstrate improved reconstruction stability and image quality with respect to unregularized approaches, while enabling robust super-resolution and optical sectioning in low-photon conditions.

We establish improved nonasymptotic bounds for Langevin Monte Carlo in the strongly log-concave setting, when the error is measured by the Wasserstein distance. The main result shows that the discretization error is governed by an average coordinate-wise smoothness constant, rather than by the usual global smoothness constant. The proof is short and probabilistic, and relies on a refined use of the synchronous coupling. We further show that the same ideas lead to improved bounds for variable step sizes, for potentials whose Laplacian is Lipschitz-continuous, and for finite-sum problems sampled by stochastic-gradient Langevin dynamics with fixed point control variates. In the Laplacian-smooth case, the usual Hessian-Lipschitz contribution is replaced by a weaker trace-type third-order smoothness quantity. In the finite-sum setting, the resulting SGLD bound improves the dependence on the root mean square smoothness of the component functions. Applications to generalized linear models with Gaussian design show that these refinements can yield substantial, dimension-dependent improvements over previously known bounds, especially for correlated covariates.

Modern machine learning techniques have become increasingly important in particle physics because of their powerful pattern-recognition capabilities, including in real-time data acquisition where stringent runtime constraints apply. This paper details the performance of deep-learning-based trigger algorithms for a large water Cherenkov detector such as Hyper-Kamiokande aimed at low-energy neutrino events (below 7 MeV). The performance of custom neural-network supervised classifiers is shown alongside two anomaly-detection approaches trained solely on detector noise: a pure autoencoder and an energy-based model based on Manifold Projection--Diffusion Recovery (MPDR). The supervised model shows signal identification efficiencies of 76.7% for single electrons of 3 MeV kinetic energy, significantly exceeding signal efficiencies obtained from a traditional hit-count-based trigger of 26.4%, as does the MPDR approach with 31.8%. Runtime evaluations on GPU yield per-window inference latencies well below the millisecond scale, indicating that real-time operation is feasible.

Agentic Retrieval-Augmented Generation improves retrieval by integrating planning, tool use, and iterative reasoning, but existing agentic RAG methods often couple semantic expansion with retrieval decisions in short-horizon inference loops, leading to high inference cost and limited suitability for time-sensitive news retrieval. We propose DynaTree, a two-stage framework for efficient and adaptive news retrieval. In the offline stage, DynaTree uses coordinated agents to construct a reusable retrieval tree that materializes the semantic space of a query topic. In the online stage, DynaTree performs lightweight daily subtree selection over a time-localized evaluation proxy, without further agentic reasoning, tree modification, or retraining. Experiments on a multi-day Syft news benchmark and multiple BEIR datasets show that DynaTree achieves strong recall and ranking performance, consistently outperforming standard RAG and prior agentic baselines. We further deploy DynaTree in the Syft production system and evaluate it through online A/B testing from Jan. 28 to Feb. 6, 2026. The dynamically adapted variant improves survival rate from 0.32-0.53 to 0.59-0.73 over a fixed offline-selected subtree and outperforms existing production recallers on every evaluation day. These results show that persistent, structure-aware semantic expansion can translate offline agentic reasoning into practical improvements in coverage, freshness, and relevance for real-world news retrieval.

In cooperative multi-agent reinforcement learning (MARL), agents must coordinate with partners whose internal policies and intentions are not directly observable. While world models such as Dreamer have demonstrated strong generalization and sample efficiency in single-agent settings, their application to MARL remains limited by an inability to handle teammate-induced uncertainty. We propose a new perspective: treat teammates as structured, learnable components within the agent's world model. We introduce an architecture that factorizes the latent state of a Dreamer-style recurrent state-space model (RSSM) into environment and teammate components, and learns an auxiliary Theory-of-Mind (ToM) head to infer latent embeddings of partner behavior such as character, intent, and predicted actions from partial trajectories. These teammate latents condition the actor and critic, enabling the agent to imagine and adapt to diverse collaborators. We outline how this approach can support zero-shot and few-shot coordination in partially observable settings and propose a set of benchmarks and evaluation protocols to assess its impact. This work positions world models as not only predictors of environmental dynamics, but as simulators of social behavior, opening new directions for generalizable, human-compatible AI.

Zeroth-order (black-box) optimization is applied when gradients are unavailable and objective evaluations rely on expensive simulations. In many such applications, the oracle fidelity is tunable: higher-accuracy queries reduce noise but incur higher computational costs. To capture this trade-off, we study an accuracy-aware wall-clock model where each query with fidelity $δ$ has a cost $c(δ)$, and we minimize the total time $T_{\mathrm{total}} = \sum_{k=1}^{N} c(δ_k)$, subject to a target accuracy constraint. We show how the choice of oracle type, noise model, and optimization scheme induces explicit wall-clock-optimal choices for the algorithmic parameters. For instance, we demonstrate that accelerated methods can be wall-clock inferior to non-accelerated schemes. Furthermore, we characterize the conditions under which a constant fidelity strategy is optimal in the Big-O sense. Our framework provides a unified methodology to translate convergence guarantees into practical fidelity and batching recommendations.

Compositional data must be analysed through log-ratios: scale invariance, the defining axiom of the field, leaves no alternative. The centred log-ratio divides by the geometric mean of every part, so a single contaminated component shifts every centred-log-ratio coordinate at once, displacing the log-ratio vector by a fixed amount that no choice of coordinates can reduce. We develop a theory of cellwise contamination on the simplex around this observation. A scale-invariant contamination model built from multiplicative perturbation combines with a propagation theorem showing that corruption of a single raw part induces a rank-one shift of the log-ratio vector, with direction determined by the contrast matrix. The resulting perturbation pattern is not equivalent to any independent cellwise contamination model in log-ratio coordinates -- so standard Euclidean cellwise methods applied to log-ratios are ill-posed under the simplex contamination mechanism. For estimators whose Euclidean cellwise breakdown is witnessed by a column-concentrated configuration -- a class including MCD, $S$-, $τ$-, and coordinate-wise $M$-estimators of location and scatter -- the cellwise breakdown value on the simplex is reduced by the factor $(D-1)/D$ relative to its Euclidean counterpart, a reduction that is tight and arises purely from the normalisation mismatch between $nD$ raw cells and $n(D-1)$ ilr cells. The cellwise influence function for the variation matrix carries a diagnostic fingerprint: contamination of a single part inflates exactly one row and column, identifying the responsible component. These results form the theoretical foundation for cellwise-robust methods on the simplex; a companion paper develops a cellwise-robust PCA estimator that exploits the propagation geometry and demonstrates it on simulated and geochemical data.

The appropriateness of empathy in AI has emerged as a critical concern, as excessive empathy risks seeming manipulative while insufficient empathy appears dismissive. While prior research has explored how to quantify empathy in AI, few studies examine whether such empathy is contextually appropriate. This paper introduces an economic perspective by applying signaling theory to human-AI conversations. We propose Signal Cost Proxies (emotional richness, perspective-taking, and contextual tailoring) mapped to affective, cognitive, and associative empathy. This multidimensional framework enables systematic evaluation of empathy not just by presence, but by its appropriateness relative to user demand.

Institutional incentives are widely used to promote cooperation among autonomous, self-regarding agents, from human societies to multi-agent and AI systems. Existing work typically treats incentive design as a bi-objective problem: minimise institutional cost while achieving a high long-run frequency of cooperation. Whether such schemes also maximise social welfare - total population payoff net of institutional expenditure - has remained largely unexplored. We develop a welfare-centric framework for institutional incentives in finite, well-mixed populations playing a social dilemma (Donation Game and Public Goods Game), considering both rewards for cooperators and punishments for defectors. For each mechanism, we derive explicit expressions for expected social welfare and characterise how it depends on incentive efficiency and selection intensity. Analytically, we identify parameter regimes where social welfare has a single optimal incentive level and regimes with qualitative phase transitions, in which welfare becomes non-monotonic with multiple local optima. We prove that any welfare-maximising incentive is either zero or concentrated around a simple closed-form target, and we provide an efficient algorithm to compute these optima. Comparing reward and punishment, we further derive close-formed conditions under which reward outperform punishment in terms of social welfare for any given budget. Overall, our results reveal a systematic gap between incentives optimised for cost or cooperation frequency and those that maximise welfare.

Networked AI systems increasingly rely on multiple agents that collaboratively learn and adapt models over communication networks. In such systems, bilevel formulations naturally arise in hyperparameter optimization, data cleaning, and meta-learning, but the repeated evaluation of gradients, Jacobians, and Hessians can impose a substantial computational burden on individual agents. To address this challenge, we propose Snapshot-SLDBO (S$^3$LDBO), an efficient single-loop decentralized bilevel optimization algorithm that enables agents to intermittently skip expensive derivative evaluations through a snapshot mechanism. This mechanism can be interpreted as an autonomous computation-adaptation strategy for networked AI, where agents selectively perform costly local updates while maintaining global collaborative learning. We establish the ergodic iteration complexity and the high probability nonergodic iteration complexity of the proposed algorithm within a deterministic setting. Experimental results on hyperparameter optimization with synthetic and MNIST datasets, data hyper-cleaning on Fashion-MNIST, and decentralized meta-learning on miniImageNet demonstrate that the proposed algorithm improves computational efficiency while maintaining competitive learning performance.

Undersampled magnetic resonance imaging (MRI) reconstruction seeks to recover temporally or contrast-varying image series from incomplete multicoil k-space data while preserving state-dependent fidelity for dynamic and quantitative MRI (qMRI). Existing scan-specific implicit neural representations (INRs) often use monolithic spatiotemporal coordinate fields, explicit subspaces, motion or deformation models, calibration variables, or sequence-specific quantitative signal models. These design choices can limit flexibility in sharing spatial information while adapting image synthesis across acquisition states. Moreover, many INR-based baselines remain computationally demanding, typically requiring per-scan optimization times on the order of hundreds to thousands of seconds. We propose MoE-dqINR, a scan-specific multicoil MRI reconstruction framework that factorizes the image-domain representation into shared spatial experts and a state-conditioned routing pathway. Spatial experts encode reusable coordinate-dependent image content, whereas routing weights, conditioned on ordered acquisition states, synthesize each dynamic frame or contrast state from a common expert bank. The representation is coupled to a multicoil MRI forward model, uses the normalized state index to drive routing in both dynamic and quantitative MRI. By separating shared spatial representation from state-dependent synthesis, the framework provides an image-first architecture for dynamic and quantitative MRI while reducing scan-specific INR optimization to approximately 30 s per scan in our experiments. The proposed formulation establishes state-conditioned mixture-of-experts INR as a scan-specific multicoil MRI reconstruction prior that unifies shared spatial representation, dynamic- and qMRI-specific synthesis, and practical per-scan efficiency.

Therapeutic mRNA design requires coordinating multiple interacting sequence features across the full transcript, where codon usage, untranslated regions (UTRs), and their coupling jointly determine stability, translation efficiency, and protein expression. Here, we present mRNA generation via unrolled trajectories and informed latent updates (mRNAutilus), a framework for simultaneous codon optimization and de novo UTR design directly from sequence. mRNAutilus combines a masked discrete diffusion model trained on millions of full-length mRNAs with Monte Carlo Tree Guidance to generate Pareto-efficient sequences under multiple functional objectives, using lightweight regressors over model embeddings to predict half-life, translation efficiency, and protein abundance. Unlike recent methods that design coding sequences and UTRs separately or rely on post hoc assembly and screening, mRNAutilus generates complete transcripts in a single process optimized across properties. Across diverse targets, zero-shot mRNAs encoding P. pyralis luciferase achieve over 400-fold higher expression than wild-type and outperform commercial and machine learning-designed baselines, including zero-shot generative approaches. Zero-shot SARS-CoV-2 Spike mRNAs exceed clinically used and commercial constructs and match or surpass lab-optimized designs with improved durability. We further demonstrate generality in therapeutic settings, including prime editing (PEMax) and programmable proteome modulation, where mRNAutilus-designed constructs enhance expression of peptide-guided E3 ligases (uAbs) for beta-catenin degradation. These results establish a sequence-based, multi-objective framework for generating functional mRNAs tailored to diverse biological applications.

Recommender systems may operate under multiple, competing objectives. For example, audience reach, cultural values, public service mandate, and operational constraints must be balanced in editorial decisions of public service media. Existing approaches relying on fixed combinations of objectives or Pareto-based optimisation do not adapt to changing priorities across situations. In this paper, we propose Contextual Scalarisation Thompson Sampler (CSTS), a multi-objective contextual bandit method that learns to weight objectives as a function of the observed context. We evaluate CSTS on real programming data from Radio Télévision Suisse, the Swiss national broadcaster, showing improved contextual relevance and better alignment with expert curation practices compared to fixed weight and standard contextual bandit approaches.

Managers in manufacturing settings rely on digital interfaces to interpret operational data for decision-making, but growing data volume and complexity can make relevant insights difficult to identify efficiently. While dashboards remain dominant in industrial contexts, Large Language Model (LLM)-based conversational agents (CAs), accessed through conversational user interfaces (CUIs), may provide more direct access to such data. However, their effectiveness may depend on the information-processing demands of the task. This study compares an LLM-based CA delivered through a CUI with a dashboard in a manufacturing decision-support scenario. In a mixed factorial experiment with a 2x3 design, 134 industrial decision-makers were assigned to one interface condition and completed three tasks of increasing complexity. We examined perceived Mental Workload (MWL), decision accuracy, completion time, and intended reliance, and tested self-reported data literacy as a moderator. Results showed that the CUI reduced perceived MWL overall and supported faster completion in less demanding tasks, but both advantages diminished as task complexity increased. Neither interface produced a consistent overall advantage in decision accuracy, and the CUI was not preferred as a sole basis for subsequent decisions. Furthermore, data literacy did not reliably moderate interface effects. These findings indicate that conversational interaction offers conditional rather than universal benefits for industrial decision support. LLM-based CAs may reduce information-access effort, whereas complex decisions continue to benefit from persistent, inspectable visual representations.

To make cross-band channel prediction practical for AI-native RAN, algorithms must generalize across diverse environments and support real-time inference. Existing approaches achieve one but not both. To bridge this gap, we introduce GUIDE, a physics-guided deep unfolding framework that embeds wireless channel physics into differentiable layers. Without retraining in unseen environments, GUIDE achieves 2.75x beamforming gain than the deep learning-based baseline FIRE with only a slight increase in inference time, and 1.39x beamforming gain than the strongest model-based baseline R2F2 while running over 1610x faster.

Traditional traffic analysis is being fundamentally challenged by the rapid adoption of encryption, tunnelling, and privacy-preserving protocols, which increasingly obscure packet payloads and limit the usefulness of Deep Packet Inspection (DPI). Although machine learning has advanced encrypted traffic analysis, existing approaches often remain tied to protocol-specific header features, depend on large labelled datasets, and degrade when deployed across heterogeneous network environments. We present GETA, a protocol-agnostic framework for encrypted traffic analysis that models network flows as multivariate time series using only traffic metadata, thereby avoiding reliance on packet payloads or header semantics. GETA combines meta-learning, embedding refinement, and self-attention to support few-shot adaptation to previously unseen domains with minimal labelled data. Across nine public datasets spanning application identification, VPN traffic classification, IoT device fingerprinting, and attack detection, GETA consistently outperforms state-of-the-art baselines. These results show that GETA offers a practical and generalisable foundation for robust traffic analysis in modern encrypted networks.

Artificial Intelligence (AI) agents personalize their responses by tailoring explanations to users' backgrounds, interests, and prior interactions, referred to as contextualization. Personalization has been identified as a persuasive strategy in politics or in marketing. However, the persuasive effect of contextualization in everyday tasks, where users often lack prior knowledge, remains unclear. We conducted a $2\times2$ between-subjects experiment ($N = 380$) examining how contextualization, combined with conversational warmth, shapes reliance and persuasiveness of an AI assistant arguing against expert recommendations. Our findings reveal that contextualization reduces the persuasive power of AI, but its combination with warmth restores persuasiveness through a crossover interaction. Reliance on AI is present across conditions and is invariant to the conversational design. Trust strongly predicts both persuasion and reliance, yet neither contextualization nor warmth operates through trust. AI literacy decouples trust from behavior: more literate users report lower trust in the assistant, yet are more persuaded and more reliant on its advice. These results suggest that users are prone to deferring to AI agents over human expert judgment; however, interface-level conversational design choices have a limited role in shaping the behavior.

We propose a unified framework for addressing three key challenges of distribution shift: (1) estimating a model's performance on an unlabeled target domain, (2) explaining the shift by identifying the features responsible, and (3) improving the target domain performance. Our method, Entropic Projection Alignment (EPA), aligns the source distribution to the target by matching carefully selected moments while simultaneously minimising the KL divergence from the source. This formulation yields a unique closed-form solution for importance weights, achieving robustness through implicit variance control. Drawing on domain adaptation theory, we establish that moment matching is sufficient for reliable estimation and adaptation, avoiding the need for full density ratio recovery. Extensive experiments, together with strong theoretical guarantees, demonstrate that EPA consistently outperforms state-of-the-art baselines while offering substantial computational efficiency.

Prompt learning is a new machine learning paradigm that has attracted ample attention due to its simplicity and proven efficacy. Despite its growing adoption, the security vulnerabilities associated with this paradigm remain underexplored. In this work, we take the first step to propose BadBone, a stealthy and adaptive backdoor attack against prompt learning using bi-level optimization. Instead of backdooring the prompt learning process, we aim to compromise a backbone model such that only target downstream tasks employing prompt learning inherit the backdoor vulnerability. Extensive experiments on three different models and three datasets from various domains show that our targeted/untargeted backdoored models achieve high attack performance while maintaining utility on both pre-training and downstream tasks. Moreover, we evaluate our approach against six state-of-the-art model-level defenses, including Neural Cleanse, ABS, MNTD, NAD, CLP, and D-BR. The results demonstrate that these defenses are largely ineffective against our backdoored models and thus leave the effective defense as an important direction for future work.