Existing inverse physics methods recover physical parameters from multi-view videos, where geometric constraints across views resolve scale and 3D structure. In monocular settings, however, such constraints are absent, leading to severe scale ambiguity, inaccurate geometry, and weak coupling between appearance optimization and physical simulation. We propose MonoPhysics, a framework for monocular inverse physics estimation of deformable objects using differentiable MPM simulation and 3D Gaussian Splatting, which jointly optimizes geometry, appearance, and physical parameters from a single camera view. We address these challenges through three visual-physical bridges: global scale alignment, physics-aware geometry refinement, and a differentiable position map, which together enable accurate optimization from monocular observations alone. We evaluate on Vid2Sim and our new dataset of elastic and plastic objects, showing that MonoPhysics outperforms existing baselines in monocular settings and achieves performance comparable to multi-view baselines using only a single camera. Our project page is available at https://daniel03c1.github.io/MonoPhysics/

A central goal of modern causal inference is estimating heterogeneous treatment effects to answer questions like "how does an intervention affect each unit," rather than only on average. We study this problem with panel-data where we observe $n$ units across $m$ times under unknown, non-uniform treatment assignments. The data in this setting is naturally represented as a matrix of all unit--time treatment effects. Estimating heterogeneous treatment effects can then be expressed as obtaining a good estimation of each row's average in this matrix. This allows us to formulate the problem as matrix completion, which can be solved under natural low-rankness assumptions. However, existing matrix-completion guarantees are not powerful enough to get meaningful bounds for the per-row guarantee required for estimating the heterogeneous treatment effect; roughly speaking, they are only useful for estimating average treatment effect bounds, as also illustrated in a recent line of work. We give a simple, computationally efficient estimator that, without knowledge of the propensities and under standard low-rankness and regularity assumptions, achieves a row-wise $\ell_2$ error of $\tilde{O}(\sqrt{\frac{1}{n} + \frac{n}{m^2}})$. Technically, our analysis establishes the first sharp row-wise $\ell_2$-perturbation bound for low-rank approximation, complementing existing spectral-, Frobenius-, and entrywise perturbation theory.

Portrait photography is largely decided before the shutter opens: the subject's pose, the camera configuration, and the lighting devices must be coordinated within the surrounding 3D scene. In contrast, most existing computational methods focus on post-production in 2D image space, such as retouching, relighting, or editing images that already exist; pre-capture photographic planning remains largely unexplored. We introduce 3D aesthetic portrait planning, the task of generating human pose, camera, lighting, and exposure plans that produce visually compelling portraits while satisfying geometric and photometric feasibility in a 3D scene. Our approach builds a Photographic Scene Graph that represents scene affordances, subject-scene relations, and portrait-relevant lighting structure. Built on this representation, we perform aesthetic-guided comparative planning over previous attempts and current viewfinder observations. Experiments across diverse indoor and outdoor scenes show that our method produces portraits preferred by human raters and MLLM evaluators over competitive baselines, while maintaining high physical plausibility. Together, our results suggest a path from post-capture correction toward pre-capture computational portrait planning. Project repository: https://github.com/songrise/Before-the-Shutter

Autoregressive image and video generators are trained with teacher-forced histories but must sample from their own generated prefixes at inference time, making them vulnerable to exposure bias and prefix drift. Existing remedies either modify training or apply sampling-time guidance aimed primarily at external semantic conditions, such as class labels or text prompts, rather than testing whether a next-step prediction provides strong posterior support for the generated prefix itself. We propose Visual Prefix Guidance (VPG), a training-free inference-time guidance method for autoregressive image and video generation. VPG improves next-step prediction by contrasting the model's output under the generated prefix with its output under a corrupted prefix, then extrapolating logits toward candidates that strengthen the posterior support of the generated prefix. Across class-conditional image generation with VAR, text-to-image generation with Infinity, and text-to-video generation with InfinityStar, VPG improves generation quality without retraining the base model, reducing FID on VAR by 0.36 on average and improving benchmark performance on both image and video generation.

Across two public LLM leaderboards, many displayed pairwise rankings do not meet a conventional paired-test resolution target under the actual paired evaluation design: 11 of 40 Open LLM Leaderboard v1 pairwise comparisons and 4 of 9 MMLU-Pro top-10 adjacent-rank pairs are unresolved at (alpha, 1-beta) = (0.05, 0.8). The MMLU-Pro count rises to 6/9 under real subject-level clustering and stays at 5-6 out of 9 in 99.9% of category-bootstrap resamples. We frame paired LLM evaluation as a hypothesis-testing problem, invert level-alpha, power-(1-beta) tests, and report a per-pair resolution ratio q = N/N* as the primary diagnostic. A sharp small-effect expansion with an explicit second-order constant shows that the widely-used unpaired Cohen-h-plus-(1-rho) shortcut deviates from the correct N* by approximately a factor of two in the close-comparison regime, a deficit that three of five off-the-shelf calculators(Cohen 1988, G*Power, R pwr) silently inherit when the user post-multiplies their per-arm output by (1-rho). The unresolved-pair pattern remains under multiplicity correction and anytime-valid sequential testing.

Digital humans are fundamental to immersive interaction, yet creating a unified model for holistic modalities, including text, audio, motion, and visual content, remains an open challenge. In this paper, we present Archon, a fully pretrained, human-centric unified multimodal model for holistic avatar generation. Archon unifies seven modalities with modality-specific tokenizers, and a native autoregressive unified multimodal model pretrained on synchronized modalities and 72 diverse tasks to model holistic joint distributions. To address the token explosion challenge in high-fidelity talking videos, we introduce a memory-efficient semantic video reparameterization, achieving 4x token reduction while preserving fine-grained dynamics, coupled with a semantic-driven video diffusion decoder. We further propose a "Thinking in Modality" that decomposes ambiguous cross-modal tasks into stepwise thinking in an alternative chain of modality, progressively enhancing fidelity and controllability. Extensive experiments demonstrate that Archon achieves superior or comparable performance across diverse digital human generation tasks, validating the effectiveness of our unified framework. Project page: https://zju3dv.github.io/archon/.

City-scale 3D surface reconstruction from multiview images for downstream 3D simulation, poses highly challenging problems due to the scale and complexity of urban scenes. Existing city-scale 3D reconstruction methods based on NeRF, Gaussian Splatting etc. often fail to recover 3D meshes ready for simulation due to incomplete/missing geometry and irregular, noisy surfaces. Scaling existing small-scale 3D reconstruction methods to arbitrarily large urban scenes is highly infeasible due to their computational complexity. We present City-Mesh3R, a scalable framework for reconstructing watertight surface meshes directly from large unordered image collections. Unlike recent methods which use global sparse SfM point-cloud initialization followed by a distributed 3D dense reconstruction of large-scale scenes, our method follows an end-to-end images-to-mesh 3D reconstruction approach using a divide-and-conquer strategy. The sparse city map is reconstructed via topological image clustering, cluster-wise independent sparse SfM and map merging, without need for exhaustive image feature matching. Then this map is partitioned spatially to perform geometry-aware camera selection, followed by dense surface reconstruction and surface refinement using curvature-aware adaptive vertex density remeshing. These partition meshes are then stitched together to produce the global mesh of the city. The proposed end-to-end framework is evaluated on city-scale reconstruction datasets. As demonstrated by our qualitative and quantitative results, our proposed method yields high-fidelity watertight 3D meshes with regular geometry, capturing fine surface details, and is suitable for scaling to arbitrarily large scenes owing to the end-to-end processing in a distributed setting.

We present GR3D, a spatial vision language model equipped with three complementary grounding capabilities--explicit 2D grounding, implicit 2D grounding, and monocular 3D grounding--within a single framework. GR3D introduces an implicit grounding mechanism that identifies entity mentions during generation and inserts the corresponding region tokens into the text stream, allowing the model to reference visual evidence on the fly when producing spatial chain-of-thought responses. In parallel, a region-prompted monocular 3D grounding design predicts 3D bounding boxes in the camera view from grounded region queries, supported by intrinsic-aware normalization and dense geometric supervision. Together, these grounding capabilities enable GR3D to decompose complex spatial understanding problems into grounded 2D perception followed by 3D inference. GR3D achieves consistent improvements across grounded and non-grounded spatial benchmarks, demonstrating grounding as an effective inductive bias for strengthening spatial understanding in VLMs. These grounding capabilities collectively enhance general spatial understanding beyond the grounding task itself.

Large language models (LLMs) show promise for clinical reasoning and decision support, but evaluation in realistic, electronic health record-congruent settings remains limited. Existing benchmarks often rely on static datasets or unstructured inputs that do not reflect the structured, interoperable data formats used in clinical systems. We introduce a pipeline for generating clinically realistic HL7 FHIR R4 bundles from unstructured text, enabling controllable evaluation of clinical decision support systems. The pipeline combines staged LLM generation with terminology-grounded validation and repair to reduce hallucinated codes and enforce structural and semantic consistency. Applying this approach to MedCaseReasoning, we construct MedCase-Structured, a synthetic dataset aligned with clinician-authored diagnostic cases, achieving valid FHIR generation for 82.5% of cases. Evaluation on MedCase-Structured reveals consistently lower diagnostic accuracy for LLMs on structured FHIR inputs than with plain text, highlighting the importance of deployment-aligned benchmarking.

Traditional cryptography, rooted in problems, e.g., integer factorisation or discrete log, is inevitably vulnerable to a fully operational quantum computer. Although it remains an engineering frontier, the looming threat extends to encrypted data stored today, which could be decrypted in the future with quantum capabilities. To safeguard against this eventuality, the backbone of the modern quantum-safe cryptography is the Shortest Vector Problem (SVP). We enhance Laarhoven's treatment of Ajtai et al.'s sieving as a genetic algorithm (GA) for the SVP by incorporating domain-informed SVP representation and crossover while naturally extending application to the module lattices.

This paper studies preference-shaped expected improvement criteria for Bayesian multiobjective optimization. We consider two indicator families which are often used for similar algorithmic purposes, but which are geometrically different. The hypervolume indicator is based on a dystopian reference point and measures dominated volume in objective space. The R2 indicator is based on a utopian point and evaluates approximation sets through weighted Tchebycheff scalarization envelopes. The purpose of the paper is to make precise which preference transformations preserve exact computation, Pareto compatibility, and monotonicity properties, and which transformations change the underlying geometry. On the hypervolume side, we revisit canonical EHVI through the Deng representation, formulate product-density weighted EHVI in desirability coordinates, discuss cone-based EHVI as ordinary EHVI after a linear cone transformation, and separate these cases from truncated EHVI, where variance monotonicity may fail. On the R2 side, we prove that exact integral R2 improvement is not, in general, an ordinary objective-space weighted hypervolume. The obstruction is lower-dimensional: Lebesgue-density hypervolume cannot see certain boundary contributions that Tchebycheff scalarizations still detect. We then show that exact integral R2 improvement is exactly a scalarization-space volume, namely the measure of the Tchebycheff shadow between the incumbent scalarization envelope and the reference envelope. This representation yields finite-sum ER2I algorithms for discrete R2, quadrature methods for exact integral R2, and an achievement-space Gaussian surrogate formulation in which ER2I is an integral of scalar Gaussian expected improvements.

Low-dimensional embeddings are widely used as visual summaries of high-dimensional data and to enable downstream scientific discoveries. Yet, popular nonlinear dimension reduction methods, such as t-SNE and UMAP, are often selected based on visual appeal alone and without rigorous quantitative validation. A major reason is that manifold embeddings typically do not provide an out-of-sample map nor an inverse back to the original feature space; this makes held-out validation, the gold standard in supervised learning, all but impossible. To address these challenges, we develop a novel framework, MEDAL (Manifold Embedding Distillation via Autoencoder Learning), which distills a fitted manifold embedding into a reusable encoder--decoder model. MEDAL trains a constrained autoencoder whose bottleneck exactly matches any teacher embedding while the decoder reconstructs the original input; this yields an explicit map for new samples, an approximate inverse, and a pointwise reconstruction-based measure of distortion in the manifold space. This converts static manifold embeddings into models that can be evaluated on held-out data, enabling quantitative validation including comparing different dimension reduction methods as well as hyperparameter tuning. Across multiple benchmark and scientific case studies, we show that MEDAL enables held-out validation to determine optimal manifold embeddings and hyperparameters, reveals biologically coherent regions that are difficult to preserve in two dimensional embeddings, and detects distribution shift when new samples are mapped into a fixed reference manifold. MEDAL provides a general validation wrapper to any existing dimension reduction technique that will improve the rigor and reliability of dimension reduction in scientific workflows.

Reinforcement learning with verifiable rewards (RLVR) has become an effective paradigm for improving reasoning language models on tasks such as mathematics, coding, and scientific question answering. However, widely used group-relative objectives, such as GRPO, summarize each sampled group with scalar statistics and therefore discard fine-grained relational information among candidate responses. This weakens credit assignment under sparse outcome rewards, especially when multiple generated solutions differ only subtly in reasoning quality. We propose \textbf{LamPO}, a \textbf{Lambda-Style Policy Optimization} method that replaces scalar group advantages with a \emph{Pairwise Decomposed Advantage}. LamPO aggregates pairwise reward gaps within each response group and modulates each comparison by a confidence-aware weight computed from sequence log-probability differences, while retaining the critic-free and clipped-update structure of PPO-style optimization. When reference solutions are available, we further add a lightweight ROUGE-L-based dense auxiliary reward to reduce reward sparsity. Experiments on AIME24, AIME25, MATH-500, and GPQA-Diamond with Qwen3-1.7B, Qwen3-4B, and Phi-4-mini show that LamPO consistently improves over GRPO and recent RLVR variants, with more stable training dynamics and better sample efficiency.

Group Relative Policy Optimization(GRPO) has become a cornerstone of modern reinforcement learning alignment, prized for its efficacy in foregoing an explicit value-critic by leveraging reward normalization across sampled trajectory cohorts. However, the method's reliance on a monolithic statistical baseline, such as the group mean, collapses the relational topology of the trajectory space into a single scalar, thereby erasing the fine-grained preference information essential for navigating complex, rank-sensitive reward landscapes. To address this issue, we introduce a novel framework, Lambda Policy Optimization (LambdaPO), that addresses this information-theoretic bottleneck by re-conceptualizing advantage estimation from a scalar value to a decomposed, pairwise preference structure. Specifically, the advantage for any given trajectory is formulated as the integrated sum of reward differentials against all peers in its cohort, where each pairwise comparison is dynamically attenuated by the policy's own probabilistic confidence in the established preference. To further mitigate the sparsity of binary outcome supervision, we augment the objective with a semantic density reward, derived from the precision-recall alignment between generated reasoning traces and ground-truth solutions. As a result, our method can mine more fine-grained optimization signals from a group of rollouts, guiding the LLM to a better optima. Experimental results across challenging math reasoning and question-answering tasks demonstrates that LambdaPO improves performance compared to the baseline methods.

The recent, super-exponential scaling of autonomous Large Language Model (LLM) agents signals a broader, fundamental paradigm shift from machines primarily replacing the human hands (manual labor and mechanical processing) to machines delegating for the human minds (cognition, reasoning, and intention). The uncontrolled offloading and scaling of "thinking" itself, beyond human's limited but efficient biological capacity, has profound consequences for humanity's heat balance sheet, since thinking, or intelligence, carries thermodynamic consequences. The Earth has already surpassed the heat dissipation threshold required for long-term ecological stability, and projecting based on empirical data reveal a concerning trajectory: without radical structural intervention, anthropogenic heat accumulation will breach critical planetary ecological thresholds in less than 6.5 years, even under the most ideal scenario where Earth Energy Imbalance (EEI) holds constant. In this work, we identify six factors from artificial intelligence that influence the global heat dissipation rate and delineate how their interplay drives society toward one of four broad macroscopic trajectories. We propose that the integration of artificial intelligence and its heat dissipation into the planetary system constitute the tenth planetary boundary (9+1). The core empirical measurement of this boundary is the net-new waste heat generated by exponential AI growth, balanced against its impact on reducing economic and societal inefficiencies and thus baseline anthropogenic waste heat emissions. We demonstrate that managing AI scaling lacks a moderate middle ground: it will either accelerate the breach of critical planetary thermodynamic thresholds, or it will serve as the single most effective lever on stabilizing the other nine planetary boundaries and through which safeguarding human civilization's survival.

Large Language Models (LLMs) possess latent multi-token prediction (MTP) abilities despite being trained only for next-token generation. We introduce ESP (Embedding-Space Probing), a simple and training-free MTP method that probes an LLM using on-the-fly mask tokens drawn from its embedding space, enabling parallel future-token prediction without modifying weights or relying on draft models. ESP constructs a speculative token tree by sampling Top-K candidates from mask-token logits and applies a lightweight pruning rule to retain high-probability continuations. During generation, predictions are verified in parallel, yielding lossless decoding while significantly reducing model calls and increasing token throughput. ESP consistently outperforms existing training-free baselines, improving acceptance length by 7-11% over LADE on LLaMA3 and 7-8% on Qwen3, and increasing throughput by up to 15-19% over the strongest baseline. Finally, we provide theoretical insight and empirical evidence showing that decoder layers naturally align mask-token representations with next-token states, enabling accurate multi-step prediction without retraining or auxiliary models.

World models require robust relational understanding to support prediction, reasoning, and control. While object-centric representations provide a useful abstraction, they are not sufficient to capture interaction-dependent dynamics. We therefore propose C-JEPA, a simple and flexible object-centric world model that extends masked joint embedding prediction from image patches to object-centric representations. By masking object-level latents and requiring each masked object state to be inferred from the surrounding context, C-JEPA imposes structured partial observability during training, creating counterfactual-like prediction queries that discourage shortcut solutions and make interaction-dependent prediction necessary under the learning objective. Empirically, C-JEPA leads to consistent gains in visual question answering, with an absolute improvement of about 20% in counterfactual reasoning over the same architecture without object-level masking. On agent control tasks, C-JEPA enables substantially more efficient planning by using only 1% of the total latent input features required by patch-based world models, while achieving comparable performance. Finally, we provide a formal analysis demonstrating that object-level masking induces useful inductive bias by controlling observability. Our code is available at https://github.com/galilai-group/cjepa.

Reasoning-oriented Large Language Models (LLMs) have achieved remarkable progress with Chain-of-Thought (CoT) prompting, yet they remain fundamentally limited by a \emph{blind self-thinking} paradigm: performing extensive internal reasoning even when critical information is missing or ambiguous. We propose Proactive Interactive Reasoning (PIR), a new reasoning paradigm that transforms LLMs from passive solvers into proactive inquirers that interleave reasoning with clarification. Unlike existing search- or tool-based frameworks that primarily address knowledge uncertainty by querying external environments, PIR targets premise- and intent-level uncertainty through direct interaction with the user. PIR is implemented via two core components: (1) an uncertainty-aware supervised fine-tuning procedure that equips models with interactive reasoning capability, and (2) a user-simulator-based policy optimization framework driven by a composite reward that aligns model behavior with user intent. Extensive experiments on mathematical reasoning, code generation, and document editing demonstrate that PIR consistently outperforms strong baselines, achieving up to 32.70\% higher accuracy, 22.90\% higher pass rate, and 41.36 BLEU improvement, while reducing nearly half of the reasoning computation and unnecessary interaction turns. Further reliability evaluations on factual knowledge, question answering, and missing-premise scenarios confirm the strong generalization and robustness of PIR. Model and code are publicly available at: \href{https://github.com/SUAT-AIRI/Proactive-Interactive-R1}

Natural generation allows Large Language Models (LLMs) to produce free-form responses with rich reasoning, yet the lack of structure makes outputs difficult to verify. Conversely, constrained decoding ensures standardized formats but can inadvertently restrict reasoning capabilities by imposing constraints too early in the generation process. We propose a hybrid approach, namely In-Writing, that combines free-form reasoning and structured generation in a single call. The model first performs unconstrained reasoning and only applies structured decoding after a trigger token is generated, explicitly decoupling reasoning from formatting. We establish that our trigger-token strategies are able to virtually eradicate premature triggering, a failure mode in which constrained decoding interrupts on-going reasoning. Evaluations across diverse datasets covering classification and reasoning tasks demonstrate that our approach outperforms the state-of-the-art by achieving accuracy gains of up to 27% over natural generation. Our code are available at: https://github.com/Nokia-Bell-Labs/InWriting.

In recent years, diffusion-based models have demonstrated exceptional performance in searching for simultaneously stable, unique, and novel (S.U.N.) crystalline materials. However, most of these models don't have the ability to change the number of atoms in the crystal during the generation process, which limits the variability of model sampling trajectories. In this paper, we demonstrate the severity of this restriction and introduce a simple yet powerful technique, mirage infusion, which enables diffusion models to change the state of the atoms that make up the crystal from existent to non-existent (mirage) and vice versa. We show that this technique improves model quality by up to x2.5 compared to the same model without this modification. The resulting model, Mirage Atom Diffusion (MiAD), is an equivariant joint diffusion model for de novo crystal generation that is capable of altering the number of atoms during the generation process. MiAD achieves an 8.2% S.U.N. rate on the MP-20 dataset, which substantially exceeds existing state-of-the-art approaches. Code: https://github.com/andrey-okhotin/miad.git

Diffusion models are central to generative modeling and have been adapted to graphs by diffusing adjacency matrix representations. The challenge of having up to $n!$ such representations for graphs with $n$ nodes is only partially mitigated by using permutation-equivariant learning architectures. Despite their computational efficiency, existing graph diffusion models struggle to distinguish certain graph families and their spectra, unless graph data are augmented with ad hoc features. This shortcoming stems from enforcing the inductive bias within the learning architecture. In this work, we leverage random matrix theory to analytically extract the spectral properties of the diffusion process, allowing us to push most of the inductive bias from the architecture into the dynamics. Building on this, we introduce the Dyson Diffusion Model, which employs Dyson's Brownian motion to capture the spectral dynamics of an Ornstein-Uhlenbeck process on the adjacency matrix. Furthermore, conditioned on the spectral dynamics, we formulate a Lie group diffusion, appropriately modeling the remaining degrees of freedom. Strikingly, the resulting learning problem becomes permutation invariant at the Lie algebra level. We demonstrate that the Dyson Diffusion Model learns graph spectra accurately and outperforms existing graph diffusion models.

Numeric tabular datasets are the dominant data format in scientific practice, yet large language models lack native mechanisms for representing numeric datasets in a meaningful way across heterogeneous feature spaces. Existing approaches either target predictive modeling over individual datasets, which requires a shared set of variable definitions, or lack mechanisms for interpretable cross-dataset alignment. The proposed methodology characterizes numeric tabular datasets through structured exploratory data analysis descriptors, embeds those descriptors into a shared vector space using a pretrained sentence transformer, and quantifies cross-dataset similarity via Canonical Correlation Analysis (CCA). Furthermore, a penalized formulation of CCA is applied to recover sparse, interpretable variable-level correspondences between datasets, identifying which statistical descriptors or variable-level quantities drive cross-dataset alignment without requiring shared variable names or feature conventions. Differential privacy is optionally applied to the descriptor set prior to embedding, supporting deployment in sensitive data contexts without requiring access to raw observations at time of comparison. The methodology is evaluated across 15 datasets spanning general-purpose benchmarks, materials informatics, and nuclear-grade graphite characterization. Results demonstrate a total P@1 score of 0.9, with known nearest-neighbor retrieval and cluster structure remaining robust across embedding ablations and differential privacy budgets. The proposed framework provides a principled pathway for integrating heterogeneous numeric data into retrieval-augmented generation pipelines while preserving statistical context, with direct applications to data-driven algorithm selection and simulation model initialization for unknown datasets.

Scientific discovery is an inherently creative and uncertain process, requiring reasoning beyond the recall of known knowledge. While many benchmarks have been proposed to evaluate large language model (LLM) performance on deep research tasks via multi-hop retrieval, their innovative reasoning abilities essential for true scientific discovery remain largely untested. We introduce a benchmark framework for evaluating model performance in scientific discovery and reasoning, building up from a raw problem to the classical null hypothesis test. In our framework, models initially receive only the topic and research question from a recent paper, with technical details progressively revealed. At each stage of information disclosure, the model is tasked with generating hypotheses that address the research question, which is compared with the conclusions from the original paper and evaluated via automated semantic similarity of constituent atomic claims. This progressive evaluation of semantic divergence from ground-truth conclusions enables assessment of a model's innovativeness (under minimal information) to grounded reasoning capabilities (under full experimental details), both critical for using LLMs for scientific discovery purposes. Our framework provides a foundation for systematically evaluating scientific reasoning and discovery capabilities in LLMs, crucial for advancing the development of next-generation AI scientist/co-scientist systems. Specifically, here we evaluate GPT-5, GPT-5.4, Gemini 2.5 pro, and Gemini 3.1 pro preview across 45 papers spanning bioactive materials, mechanical materials, and nanomaterials. We find that GPT-5.4 and Gemini 3.1 pro outperform their previous generation counterparts as expected, and GPT-5.4 in particular maintains 0.7 F1 score alignment with ground truth conclusions even under minimal context.

MCP Server Proto-OKN (mcp-proto-okn) is a Python-based Model Context Protocol server that enables AI assistants to discover, inspect, query and integrate scientific knowledge graphs through natural language. The server provides graph routing, schema inspection, SPARQL execution, ontology expansion, multi-graph querying, and transcript generation, lowering the barrier to cross-domain knowledge graph analysis for biomedical and scientific users. mcp-proto-okn is implemented in Python using the FastMCP framework and is available at https://github.com/sbl-sdsc/mcp-proto-okn. Documentation, client configuration instructions, and example analysis transcripts are provided in the GitHub repository.

Vision-Language-Action (VLA) models have recently shown strong potential for robot learning by following language instructions. However, in practice, language alone is often insufficient to precisely convey human intent. It is difficult to describe which exact object to interact with among similar candidates, where to act on the object, or how the target may change during execution. To address this limitation, we propose Gaze2Act, a novel VLA framework that leverages human gaze as a dynamic and intuitive intent signal for complex interactive manipulation. Gaze2Act first bridges the ego-exo view gap by mapping first-person gaze into the robot's perspective through cross-view semantic matching, producing both an object mask and a gaze point for coarse-to-fine target specification. These cues are then integrated into the policy through perception-level prompting and action-level conditioning, allowing the robot to attend to relevant regions and execute precise interactions under dynamic intent. In a systematic evaluation across seven task categories and 16 real-robot tasks on a Unitree G1 humanoid, Gaze2Act achieves state-of-the-art performance in both intent accuracy and task success rate. It notably outperforms baselines in object disambiguation, fine-grained interaction, and dynamic intent steering. These results demonstrate that human gaze provides a natural, low-burden, and highly expressive modality for human-in-the-loop VLA control.

Real-time thermal-hydraulic simulation is essential for digital twin (DT) technology that supports the safe and efficient operation of small modular reactors (SMRs). Computational fluid dynamics (CFD) provides high-fidelity flow analysis, but its computational cost prevents direct use in DT applications. AI-based surrogate modeling has been actively investigated to address this limitation, yet neural operator--based surrogates for CFD-level transient analysis of SMR-specific geometries have not been reported. This study presents an integrated framework that combines a reduced-order model (ROM) with neural operators, applied to the helical coil steam generator (HCSG) of the System-integrated Modular Advanced Reactor (SMART). Two ROM strategies tailored to each CFD data type were compared, an MLP-based autoencoder (AE) for unstructured mesh data and a convolutional autoencoder (CAE) for structured mesh data, and each was coupled with the deep operator network (DeepONet) to construct the latent DeepONet (L-DeepONet). The Fourier neural operator (FNO) was additionally adopted for comparison. A multi-scale technique was incorporated into both frameworks to mitigate spectral bias and improve the prediction of Kármán vortex streets developing inside the HCSG. The multi-scale L-DeepONet captured the instantaneous periodic vortex dynamics in both velocity and pressure fields, while the FNO and its multi-scale variant predicted the time-averaged mean flow and provided reliable pressure drop estimates. These complementary characteristics provide a practical model-selection guideline that links each architecture to specific DT objectives based on CFD data type and the required level of flow resolution.

Earlier detection of pancreatic cancer is key to enabling wider access to curative treatment and reducing cancer deaths; however, screening is presently not viable. Latent indicators of pathology are evident in an individual's disease and blood test trajectories and may predict the development of pancreatic cancer. Longitudinal sequences of coded diagnoses and blood test values accrued by patients throughout their clinical interactions were used to train a custom Transformer-based neural network with a multi-head attention mechanism to predict risk of pancreatic cancer with a multi-year lead time and risk-stratify populations for targeted screening. The cohort comprised 6,017 adults with pancreatic cancer and 177,081 controls (overall median age 75, 45% female) with median 12 years (interquartile range 6.9-16.2) of medical history prior to pancreatic cancer diagnosis. External validation via leave-one-site-out, out-of-sample testing predicting pancreatic cancer 1-, 2-, and 3-years prior to diagnosis demonstrated mean area under the receiver operating characteristic of 0.837 (95% confidence interval 0.827-0.848), 0.797 (95% confidence interval 0.782-0.813), and 0.760 (95% confidence interval 0.745-0.776), respectively. Estimated pancreatic cancer risks were well-calibrated (calibration plot slope 1.08, intercept of -0.077; Brier score 0.025), and a Bayesian population pancreatic cancer prevalence update allows estimated cancer risk outputs to be transportable across settings. At testing, a screening threshold of >3.3% risk of pancreatic cancer in 1-year offered a diagnostic odds ratio of 18.2. Our work therefore lays the foundation for a first population-level digital enrichment tool to widen access to curative-intent management of pancreatic cancer.

Document-level translation remains one of the most challenging tasks for large language models, which are constrained by limited context windows that impede global cohesion, while simultaneously suffering from redundant contextual information that degrades translation quality. To address this, we propose a human-like long document translation agent called Loong, which leverages a 3E memory module (Essence-Exemplar-Entity) to store summaries, sentence pairs, and entity records as historical context. Instead of passively attending to all history, Loong performs deep reasoning to adaptively identify the optimal context for translation guidance. Loong optimizes its context policy through reinforcement learning, utilizing preference data derived from its own sampled observe-and-act reasoning trajectories. Empirical evaluations demonstrate that Loong achieves substantial translation quality improvements in English $\Leftrightarrow$ Chinese, German, and French directions, with average gains of up to 13.0 points across the three evaluation metrics. Furthermore, Loong exhibits strong generalization across domains and robustness against contextual noise, while maintaining remarkable stability in ultra-long document translation. Our code is released at https://github.com/YutongWang1216/LoongDocMT.

Large language models (LLMs) show promise in generating supportive responses for mental health queries, but improving their usefulness, empathy, and safety often requires substantial compute, expert input, and labeled data. At the same time, deploying proprietary, cloud-based models for mental health-related interactions raises important privacy and data-governance concerns, given the sensitivities. To address this challenge, we introduce LLUMI setup that can be hosted in-house within protected environments. LLUMI consists of two complementary components: a generation model (GM), which drafts supportive responses to mental health queries, and an improvement model (IM), which revises an initial human-crafted response. We leverage feedback signals from Reddit mental health communities, using community endorsement patterns such as upvotes and downvotes to construct chosen-rejected response pairs for Supervised Fine Tuning (SFT) and Direct Preference Optimization (DPO). We further align LLUMI using human evaluation across five dimensions: readability, empathy, connection, actionability, and safety. Our results show that, despite relying on smaller open-source models rather than proprietary cloud-based GPT models, LLUMI achieves comparable performance across linguistic analyses and human evaluations. These findings suggest that open-source models, when trained with community-derived preference signals, can support high-quality mental health support assistance while offering a more privacy-preserving alternative for sensitive support contexts.

Over the past decades, numerous Image Quality Assessment (IQA) models have emerged, aiming to predict the perceptual quality of images. However, individual models are often biased toward certain types of image content or distortions, depending on the design principle and process. An intuitive idea is to harness the strengths and mitigate the weaknesses of each IQA model, by fusing the scores of multiple models into a stronger one. Here we make one of the first attempts to seek an optimal solution for the idea and propose a general framework for unsupervised IQA score fusion using deep Maximum a Posteriori (MAP) estimation. The proposed model conducts fine-grained uncertainty estimation at the score level to increase the accuracy and reduce the uncertainty in fused predictions. Comprehensive experiments demonstrate the superiority of the proposed model over individual IQA models and other fusion methods. It also exhibits an interesting capability of rejecting ``bad" models in the fusion process.