Deep Learning Strain Estimation: Is Physics-Based Simulation the Solution?
深度学习应变估计:基于物理的模拟是解决方案吗?
Thierry Judge, Nicolas Duchateau, Andreas Østvik, Khuram Faraz, Anders Austlid Taskén, Sigve Karlsen, Thor Edvardsen, Harald Brunvand, Md Abulkalam Azad, Havard Dalen, Bjørnar Grenne, Gabriel Kiss, Pierre-Yves Courand, Lasse Lovstakken, Pierre-Marc Jodoin, Olivier Bernard
AI总结 针对超声心动图中应变估计缺乏可靠运动参考的问题,提出一种结合真实视频散斑去相关测量与迭代细化过程的模拟策略,生成逼真数据集训练运动估计算法,在全局和区域应变上达到优于临床参考的性能。
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斑点追踪超声心动图(STE)是心肌应变估计的临床标准。尽管在全局应变(GLS)上表现良好,但其区域应变的准确性仍然有限,尽管这一生物标志物对于早期诊断和表征细微异常高度相关。深度学习是一种有前景的替代方案,但其发展受到缺乏可靠运动参考的限制。现有解决方案要么依赖于STE衍生的标签,要么依赖于基于物理模型生成的模拟,但这些合成序列与临床数据相比仍缺乏足够的真实性。在本文中,我们提出了一种新的模拟策略,该策略结合了来自真实视频的散斑去相关测量,并使用迭代细化过程来改善模拟中的运动真实性。我们创建了一个包含1,478个视频及其参考运动的开源逼真数据集,用于训练超声心动图运动估计算法。所提出的方法在全局和区域应变上实现了无与伦比的性能,特别是在专家间设置中,GLS变异性达到1.42%,而临床参考为1.78%。
Speckle tracking echocardiography (STE) is the clinical standard for myocardial strain estimation. Despite good performance on global strain (GLS), its accuracy for regional strain remains limited, even though this biomarker is highly relevant for early diagnosis and the characterization of subtle abnormalities. from clinical data. Deep learning is a promising alternative, but its development is constrained by the lack of reliable motion references. Existing solutions rely either on STE-derived labels or on simulations generated by physics-based models, but these synthetic sequences still have limited realism compared with clinical data.In this paper, we propose a novel simulation strategy that incorporates speckle decorrelation measures from real videos and uses an iterative refinement process to improve the motion realism in the simulations. We created an open-source photorealistic dataset of 1,478 videos with reference motion, which was used to train an echocardiographic motion estimation algorithm. The proposed method achieves unmatched performance on global and regional strain, notably reaching a GLS variability of 1.42% in an inter-expert setting compared to 1.78% for the clinical reference.