2605.26026
2026-05-26
cs.CV
cs.AI
cs.LG
A Multimodal 3D Foundation Model for Light Sheet Fluorescence Microscopy Enables Few-Shot Segmentation, Classification, and Deblurring
一种用于光片荧光显微镜的多模态3D基础模型实现少样本分割、分类和去模糊
Adina Scheinfeld, Haotan Zhang, Shang Mu, Rudolf L. M. van Herten, Lucas Stoffl, Ali Erturk, Zhuhao Wu, Johannes C. Paetzold
发表机构
*
Tri-Institutional Program in Computational Biology \& Medicine, Weill Cornell Medicine, New York, NY, USA Department of Radiology, Weill Cornell Medicine, New York, NY, USA Helen
;
Robert Appel Alzheimers Disease Research Institute, Feil Family Brain
;
Mind Research Institute, Weill Cornell Medicine, New York, NY, USA Graduate Program in Physiology, Biophysics
;
Systems Biology, Weill Cornell Medicine, New York, NY, USA Cornell Tech, New York, NY, USA Institute for Intelligent Biotechnologies (iBIO), Helmholtz Center Munich, Neuherberg, Germany Institute for Stroke
;
Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University Munich, Munich, Germany
AI总结
提出一种基于掩码重建与图像-文本对齐联合优化的3D基础模型,在光片荧光显微镜数据上预训练,通过少样本适应显著降低标注成本并提升分割、分类和去模糊性能。