In this paper, we propose a sequential recommendation model that integrates Time-aware personalization, Multi-interest personalization, and Explanation personalization for Personalized Sequential Recommendation (TME-PSR). That is, we consider the differences across different users in temporal rhythm preference, multiple fine-grained latent interests, and the personalized semantic alignment between recommendations and explanations. Specifically, the proposed TME-PSR model employs a dual-view gated time encoder to capture personalized temporal rhythms, a lightweight multihead Linear Recurrent Unit architecture that enables fine-grained sub-interest modeling with improved efficiency, and a dynamic dual-branch mutual information weighting mechanism to achieve personalized alignment between recommendations and explanations. Extensive experiments on real-world datasets demonstrate that our method consistently improves recommendation accuracy and explanation quality, at a lower computational cost.

Three-dimensional (3D) data visualizations, such as surface plots, are vital in STEM fields from biomedical imaging to spectroscopy, yet remain largely inaccessible to blind and low-vision (BLV) people. To address this gap, we conducted an Experience-Based Co-Design with BLV co-designers with expertise in non-visual data representations to create an accessible, multi-modal, web-native visualization tool. Using a multi-phase methodology, our team of five BLV and one non-BLV researcher(s) participated in two iterative sessions, comparing a low-fidelity tactile probe with a high-fidelity digital prototype. This process produced a prototype with empirically grounded features, including reference sonification, stereo and volumetric audio, and configurable buffer aggregation, which our co-designers validated as improving analytic accuracy and learnability. In this study, we target core analytic tasks essential for non-visual 3D data exploration: orientation, landmark and peak finding, comparing local maxima versus global trends, gradient tracing, and identifying occluded or partially hidden features. Our work offers accessibility researchers and developers a co-design protocol for translating tactile knowledge to digital interfaces, concrete design guidance for future systems, and opportunities to extend accessible 3D visualization into embodied data environments.

Just Recognizable Difference (JRD) boosts coding efficiency for machine vision through visibility threshold modeling, but is currently limited to a single-task scenario. To address this issue, we propose a Multi-Task JRD (MT-JRD) dataset and an Attribute-assisted MT-JRD (AMT-JRD) model for Video Coding for Machines (VCM), enhancing both prediction accuracy and coding efficiency. First, we construct a dataset comprising 27,264 JRD annotations from machines, supporting three representative tasks including object detection, instance segmentation, and keypoint detection. Secondly, we propose the AMT-JRD prediction model, which integrates Generalized Feature Extraction Module (GFEM) and Specialized Feature Extraction Module (SFEM) to facilitate joint learning across multiple tasks. Thirdly, we innovatively incorporate object attribute information into object-wise JRD prediction through the Attribute Feature Fusion Module (AFFM), which introduces prior knowledge about object size and location. This design effectively compensates for the limitations of relying solely on image features and enhances the model's capacity to represent the perceptual mechanisms of machine vision. Finally, we apply the AMT-JRD model to VCM, where the accurately predicted JRDs are applied to reduce the coding bit rate while preserving accuracy across multiple machine vision tasks. Extensive experimental results demonstrate that AMT-JRD achieves precise and robust multi-task prediction with a mean absolute error of 3.781 and error variance of 5.332 across three tasks, outperforming the state-of-the-art single-task prediction model by 6.7% and 6.3%, respectively. Coding experiments further reveal that compared to the baseline VVC and JPEG, the AMT-JRD-based VCM improves an average of 3.861% and 7.886% Bjontegaard Delta-mean Average Precision (BD-mAP), respectively.

This paper argues that a one-size-fits-all approach to specifying consent for the use of creative works in generative AI is insufficient. Real-world ownership and rights holder structures, the imitation of artistic styles and likeness, and the limitless contexts of use of AI outputs make the status quo of binary consent with opt-in by default untenable. To move beyond the current impasse, we consider levers of control in generative AI workflows at training, inference, and dissemination. Based on these insights, we position inference-time opt-in as an overlooked opportunity for nuanced consent verification. We conceptualize nuanced consent conditions for opt-in and propose an agent-based inference-time opt-in architecture to verify if user intent requests meet conditional consent granted by rights holders. In a case study for music, we demonstrate that nuanced opt-in at inference can account for established rights and re-establish a balance of power between rights holders and AI developers.

Agent ecosystems increasingly rely on installable skills to extend functionality, and some skills bundle learned model artifacts as part of their execution logic. This creates a supply-chain risk that is not captured by prompt injection or ordinary plugin misuse: a third-party skill may appear benign while concealing malicious behavior inside its bundled model. We present BadSkill, a backdoor attack formulation that targets this model-in-skill threat surface. In BadSkill, an adversary publishes a seemingly benign skill whose embedded model is backdoor-fine-tuned to activate a hidden payload only when routine skill parameters satisfy attacker-chosen semantic trigger combinations. To realize this attack, we train the embedded classifier with a composite objective that combines classification loss, margin-based separation, and poison-focused optimization, and evaluate it in an OpenClaw-inspired simulation environment that preserves third-party skill installation and execution while enabling controlled multi-model study. Our benchmark spans 13 skills, including 8 triggered tasks and 5 non-trigger control skills, with a combined main evaluation set of 571 negative-class queries and 396 trigger-aligned queries. Across eight architectures (494M--7.1B parameters) from five model families, BadSkill achieves up to 99.5\% average attack success rate (ASR) across the eight triggered skills while maintaining strong benign-side accuracy on negative-class queries. In poison-rate sweeps on the standard test split, a 3\% poison rate already yields 91.7\% ASR. The attack remains effective across the evaluated model scales and under five text perturbation types. These findings identify model-bearing skills as a distinct model supply-chain risk in agent ecosystems and motivate stronger provenance verification and behavioral vetting for third-party skill artifacts.

Labelling tissue components in histology whole slide images (WSIs) is prohibitively labour-intensive: a single slide may contain tens of thousands of structures--cells, nuclei, and other morphologically distinct objects--each requiring manual boundary delineation and classification. We present a cloudnative, end-to-end pipeline that automates this process through a cluster-first paradigm. Our system tiles WSIs, filters out tiles deemed unlikely to contain valuable information, segments tissue components with Cellpose-SAM (including cells, nuclei, and other morphologically similar structures), extracts neural embeddings via a pretrained ResNet-50, reduces dimensionality with UMAP, and groups morphologically similar objects using DBSCAN clustering. Under this paradigm, a human annotator labels representative clusters rather than individual objects, reducing annotation effort by orders of magnitude. We evaluate the pipeline on 3,696 tissue components across 13 diverse tissue types from three species (human, rat, rabbit), measuring how well unsupervised clusters align with independent human labels via per-tile Hungarian-algorithm matching. Our system achieves a weighted cluster-label alignment accuracy of 96.8%, with 7 of 13 tissue types reaching perfect agreement. The pipeline, a companion labelling web application, and all evaluation code are released as open-source software.

Generative models can now propose thousands of \emph{de novo} antibody sequences, yet translating these designs into viable therapeutics remains constrained by the cost of biophysical characterization. Here we present CrossAbSense, a framework of property-specific neural oracles that combine frozen protein language model encoders with configurable attention decoders, identified through a systematic hyperparameter campaign totaling over 200 runs per property. On the GDPa1 benchmark of 242 therapeutic IgGs, our oracles achieve notable improvements of 12--20\% over established baselines on three of five developability assays and competitive performance on the remaining two. The central finding is that optimal decoder architectures \emph{invert} our initial biological hypotheses: self-attention alone suffices for aggregation-related properties (hydrophobic interaction chromatography, polyreactivity), where the relevant sequence signatures -- such as CDR-H3 hydrophobic patches -- are already fully resolved within single-chain embeddings by the high-capacity 6B encoder. Bidirectional cross-attention, by contrast, is required for expression yield and thermal stability -- properties that inherently depend on the compatibility between heavy and light chains. Learned chain fusion weights independently confirm heavy-chain dominance in aggregation ($w_H = 0.62$) versus balanced contributions for stability ($w_H = 0.51$). We demonstrate practical utility by deploying CrossAbSense on 100 IgLM-generated antibody designs, illustrating a path toward substantial reduction in experimental screening costs.

Large language model (LLM) agents are increasingly deployed as scalable user simulators for recommender system evaluation. Yet existing simulators perceive recommendations through text or structured metadata rather than the visual interfaces real users browse-a critical gap, since attention over recommendation layouts is both visually driven and highly personalized. We investigate whether aligning a vision-language model's (VLM's) visual attention with user-specific gaze patterns can improve simulation fidelity. Analysis of a real-world eye-tracking dataset collected in a carousel-based recommendation setting reveals that users exhibit stable individual gaze patterns strongly predictive of click behavior. Building on this finding, we propose Fixation-Aligned Tuning for user Emulation (FixATE). Our approach first probes the VLM's internal visual attention via interpretability operators to obtain a slot-level relevance distribution comparable with human fixation, and then learns personalized soft prompts to steer the model's attention toward each user's characteristic fixation pattern. Experiments across three interpretability-based probing operators and two architecturally distinct VLM backbones demonstrate consistent improvements in both attention alignment and click prediction accuracy. These results suggest that making the model "see like the user" is a viable path toward simulators that more faithfully reproduce how users perceive and act in recommendation interfaces.

The rapid proliferation of Large Language Model (LLM) providers--each exposing proprietary API formats--has created a fragmented ecosystem where applications become tightly coupled to individual vendors. Switching or bridging providers requires $O(N^2)$ bilateral adapters, impeding portability and multi-provider architectures. We observe that despite substantial syntactic divergence, the major LLM APIs share a common semantic core: the practical challenge is the combinatorial surface of syntactic variations, not deep semantic incompatibility. Based on this finding, we present LLM-Rosetta, an open-source translation framework built on a hub-and-spoke Intermediate Representation (IR) that captures the shared semantic core--messages, content parts, tool calls, reasoning traces, and generation controls--in a 9-type content model and 10-type stream event schema. A modular Ops-composition converter architecture enables each API standard to be added independently. LLM-Rosetta supports bidirectional conversion (provider-to-IR-to-provider) for both request and response payloads, including chunk-level streaming with stateful context management. We implement converters for four API standards (OpenAI Chat Completions, OpenAI Responses, Anthropic Messages, and Google GenAI), covering the vast majority of commercial providers. Empirical evaluation demonstrates lossless round-trip fidelity, correct streaming behavior, and sub-100 microsecond conversion overhead--competitive with LiteLLM's single-pass approach while providing bidirectionality and provider neutrality. LLM-Rosetta passes the Open Responses compliance suite and is deployed in production at Argonne National Laboratory. Code is available at https://github.com/Oaklight/llm-rosetta.

In this letter, we consider the problem of decentralized decision making among connected autonomous vehicles at unsignalized intersections, where existing centralized approaches do not scale gracefully under mixed maneuver intentions and coordinator failure. We propose a closed-loop opinion-dynamic decision model for intersection coordination, where vehicles exchange intent through dual signed networks: a conflict topology based communication network and a commitment-driven belief network that enable cooperation without a centralized coordinator. Continuous opinion states modulate velocity optimizer weights prior to commitment; a closed-form predictive feasibility gate then freezes each vehicle's decision into a GO or YIELD commitment, which propagates back through the belief network to pre-condition neighbor behavior ahead of physical conflicts. Crossing order emerges from geometric feasibility and arrival priority without the use of joint optimization or a solver. The approach is validated across three scenarios spanning fully competitive, merge, and mixed conflict topologies. The results demonstrate collision-free coordination and lower last-vehicle exit times compared to first come first served (FCFS) in all conflict non-trivial configurations.

Considering efficiency, ultra-high-definition (UHD) low-light image restoration is extremely challenging. Existing methods based on Transformer architectures or high-dimensional complex convolutional neural networks often suffer from the "memory wall" bottleneck, failing to achieve millisecond-level inference on edge devices. To address this issue, we propose a novel real-time UHD low-light enhancement network based on geometric feature fusion using Clifford algebra in 2D Euclidean space. First, we construct a four-layer feature pyramid with gradually increasing resolution, which decomposes input images into low-frequency and high-frequency structural components via a Gaussian blur kernel, and adopts a lightweight U-Net based on depthwise separable convolution for dual-branch feature extraction. Second, to resolve structural information loss and artifacts from traditional high-low frequency feature fusion, we introduce spatially aware Clifford algebra, which maps feature tensors to a multivector space (scalars, vectors, bivectors) and uses Clifford similarity to aggregate features while suppressing noise and preserving textures. In the reconstruction stage, the network outputs adaptive Gamma and Gain maps, which perform physically constrained non-linear brightness adjustment via Retinex theory. Integrated with FP16 mixed-precision computation and dynamic operator fusion, our method achieves millisecond-level inference for 4K/8K images on a single consumer-grade device, while outperforming state-of-the-art (SOTA) models on several restoration metrics.

Mechanistic understanding and rational design of complex chemical systems depend on fast and accurate predictions of electronic structures beyond individual building blocks. However, if the system exceeds hundreds of atoms, first-principles quantum mechanical (QM) modeling becomes impractical. In this study, we developed FB-GNN-MBE by integrating a fragment-based graph neural network (FB-GNN) into the many-body expansion (MBE) theory and demonstrated its capacity to reproduce first-principles potential energy surfaces (PES) for hierarchically structured systems with manageable accuracy, complexity, and interpretability. Specifically, we divided the entire system into basic building blocks (fragments), evaluated their one-fragment energies using a QM model, and addressed many-fragment interactions using the structure-property relationships trained by FB-GNNs. Our investigation shows that FB-GNN-MBE achieves chemical accuracy in predicting two-body (2B) and three-body (3B) energies across water, phenol, and mixture benchmarks, as well as the one-dimensional dissociation curves of water and phenol dimers. To transfer the success of FB-GNN-MBE across various systems with minimal computational costs and data demands, we developed and validated a teacher-student learning protocol. A heavy-weight FB-GNN trained on a mixed-density water cluster ensemble (teacher) distills its learned knowledge and passes it to a light-weight GNN (student), which is later fine-tuned on a uniform-density (H2O)21 cluster ensemble. This transfer learning strategy resulted in efficient and accurate prediction of 2B and 3B energies for variously sized water clusters without retraining. Our transferable FB-GNN-MBE framework outperformed conventional non-FB-GNN-based models and showed high practicality for large-scale molecular simulations.

UAV images are critical for applications such as large-area mapping, infrastructure inspection, and emergency response. However, in real-world flight environments, a single image is often affected by multiple degradation factors, including rain, haze, and noise, undermining downstream task performance. Current unified restoration approaches typically rely on implicit degradation representations that entangle multiple factors into a single condition, causing mutual interference among heterogeneous corrections. To this end, we propose DAME-Net, a Degradation-Aware Mixture-of-Experts Network that decouples explicit degradation perception from degradation-conditioned reconstruction for compositional UAV image restoration. Specifically, we design a Factor-wise Degradation Perception module(FDPM) to provide explicit per-factor degradation cues for the restoration stage through multi-label prediction with label-similarity-guided soft alignment, replacing implicit entangled conditions with interpretable and generalizable degradation descriptions. Moreover, we develop a Conditioned Decoupled MoE module(CDMM) that leverages these cues for stage-wise conditioning, spatial-frequency hybrid processing, and mask-constrained decoupled expert routing, enabling selective factor-specific correction while suppressing irrelevant interference. In addition, we construct the Multi-Degradation UAV Restoration benchmark (MDUR), the first large-scale UAV benchmark for compositional UAV image restoration, with 43 degradation configurations from single degradations to four-factor composites and standardized seen/unseen splits.Extensive experiments on MDUR demonstrate consistent improvements over representative unified restoration methods, with greater gains on unseen and higher-order composite degradations. Downstream experiments further validate benefits for UAV object detection.

The Half-Trek Criterion (HTC) is the primary graphical tool for determining generic identifiability of causal effect coefficients in linear structural equation models (SEMs) with latent confounders. However, HTC is inherently node-wise: it simultaneously resolves all incoming edges of a node, leaving a gap of "inconclusive" causal effects (15-23% in moderate graphs). We introduce Iterative Identification Closure (IIC), a general framework that decouples causal identification into two phases: (1) a seed function S_0 that identifies an initial set of edges from any external source of information (instrumental variables, interventions, non-Gaussianity, prior knowledge, etc.); and (2) Reduced HTC propagation that iteratively substitutes known coefficients to reduce system dimension, enabling identification of edges that standard HTC cannot resolve. The core novelty is iterative identification propagation: newly identified edges feed back to unlock further identification -- a mechanism absent from all existing graphical criteria, which treat each edge (or node) in isolation. This propagation is non-trivial: coefficient substitution alters the covariance structure, and soundness requires proving that the modified Jacobian retains generic full rank -- a new theoretical result (Reduced HTC Theorem). We prove that IIC is sound, monotone, converges in O(|E|) iterations (empirically <=2), and strictly subsumes both HTC and ancestor decomposition. Exhaustive verification on all graphs with n<=5 (134,144 edges) confirms 100% precision (zero false positives); with combined seeds, IIC reduces the HTC gap by over 80%. The propagation gain is gamma~4x (2 seeds identifying ~3% of edges to 97.5% total identification), far exceeding gamma<=1.2x of prior methods that incorporate side information without iterative feedback.

Quantum networks are expected to become a key enabler for interconnecting quantum devices. In contrast to classical communication networks, however, information transfer in quantum networks is usually restricted to short distances due to physical constraints of entanglement distribution. Satellites can extend entanglement distribution over long distances, but routing in such networks is challenging because satellite motion and stochastic link generation create a highly dynamic quantum topology. Existing routing methods often rely on global topology information that quickly becomes outdated due to delays in the classical control plane, while decentralized methods typically act on incomplete local information. We propose SatQNet, a reinforcement learning approach for entanglement routing in satellite-assisted quantum networks that can be decentralized at runtime. Its key innovation is an edge-centric directed line graph neural network that performs local message passing on directed edge embeddings, enabling it to better capture link properties in high-degree and time-varying topologies. By exchanging messages with neighboring repeaters, SatQNet learns a local graph representation at runtime that supports agents in establishing high-fidelity end-to-end entanglements. Trained on random graphs, SatQNet outperforms heuristic and learning-based approaches across diverse settings, including a real-world European backbone topology, and generalizes to unseen topologies without retraining.

We consider machine learning tasks with low-rank functional tree tensor networks (TTN) as the learning model. While in the case of least-squares regression, low-rank functional TTNs can be efficiently optimized using alternating optimization, this is not directly possible in other problems, such as multinomial logistic regression. We propose a natural Riemannian gradient descent type approach applicable to arbitrary losses which is based on the natural gradient by Amari. In particular, the search direction obtained by the natural gradient is independent of the choice of basis of the underlying functional tensor product space. Our framework applies to both the factorized and manifold-based approach for representing the functional TTN. For practical application, we propose a hierarchy of efficient approximations to the true natural Riemannian gradient for computing the updates in the parameter space. Numerical experiments confirm our theoretical findings on common classification datasets and show that using natural Riemannian gradient descent for learning considerably improves convergence behavior when compared to standard Riemannian gradient methods.

Developing optical systems for free-space applications requires simulation tools that accurately capture turbulence-induced wavefront distortions and support gradient-based optimization. Here we introduce TurPy, a GPU-accelerated, fully differentiable wave optics turbulence simulator to bridge high fidelity simulation with end-to-end optical system design. TurPy incorporates subharmonic phase screen generation, autoregressive temporal evolution, and an automated screen placement routine balancing Fourier aliasing constraints and weak-turbulence approximations into a unified, user-ready framework. Because TurPy's phase screen generation is parameterized through a media-specific power spectral density, the framework extends to atmospheric, oceanic, and biological propagation environments with minimal modification. We validate TurPy against established atmospheric turbulence theory by matching 2nd order Gaussian beam broadening and 4th order plane wave scintillation to closed-form models with 98% accuracy across weak to strong turbulence regimes, requiring only the medium's refractive index structure constant and power spectral density as inputs. To demonstrate TurPy as a gradient-based training platform, we optimize a dual-domain diffractive deep neural network (D2NN) in a two-mask dual-domain architecture to recover a Gaussian beam from a weakly turbulent path and achieving over 20x reduction in scintillation relative to an uncompensated receiver in simulation. TurPy is released as an open-source package to support synthetic data generation, turbulence-informed algorithm development, and the end-to-end design of optical platforms operating in turbulent environments.

LLM-generated explanations can make technical content more accessible, but there is a ceiling on what they can support interactively. Because LLM outputs are static text, they cannot be executed or stepped through. We argue that grounding explanations in a formalized representation enables interactive affordances beyond what static text supports. We instantiate this idea for mathematical proof comprehension with explorable theorems, a system that uses LLMs to translate a theorem and its written proof into Lean, a programming language for machine-checked proofs, and links the written proof with the Lean code. Readers can work through the proof at a step-level granularity, test custom examples or counterexamples, and trace the logical dependencies bridging each step. Each worked-out step is produced by executing the Lean proof on that example and extracting its intermediate state. A user study ($n = 16$) shows potential advantages of this approach: in a proof-reading task, participants who had access to the provided explorability features gave better, more correct, and more detailed answers to comprehension questions, demonstrating a stronger overall understanding of the underlying mathematics.

Two-sample testing, where we aim to determine whether two distributions are equal or not equal based on samples from each one, is challenging if we cannot place assumptions on the properties of the two distributions. In particular, certifying equality of distributions, or even providing a tight upper bound on the total variation (TV) distance between the distributions, is impossible to achieve in a distribution-free regime. In this work, we examine the blurred TV distance, a relaxation of TV distance that enables us to perform inference without assumptions on the distributions. We provide theoretical guarantees for distribution-free upper and lower bounds on the blurred TV distance, and examine its properties in high dimensions.

Human animation aims to generate temporally coherent and visually consistent videos over long sequences, yet modeling long-range dependencies while preserving frame quality remains challenging. Inspired by the human ability to leverage past observations for interpreting ongoing actions, we propose FrameCache, a training-free, causality-consistent reference frame framework. FrameCache explicitly converts historical generation results into causal guidance through two complementary mechanisms. First, at the reference level, a novel Screen-Cache-Match (SCM) strategy constructs a dynamic, high-quality reference memory, ensuring motion-consistent appearance guidance to reduce identity drift. Second, at the generative level, a Trajectory-Aware Autoregressive Generation (TAAG) mechanism aligns denoising trajectories across adjacent video chunks. This is achieved through an overlap-aware latent propagation and a dual-domain fusion strategy that seamlessly blends low-frequency structural layouts with high-frequency textural details. Extensive experiments on standard benchmarks demonstrate that FrameCache consistently improves temporal coherence and visual stability while integrating seamlessly with diverse diffusion baselines. Code will be made publicly available.

Quantum networks are becoming increasingly important because of advancements in quantum computing and quantum sensing, such as recent developments in distributed quantum computing and federated quantum machine learning. Routing entanglement in quantum networks poses several fundamental as well as technical challenges, including the high dynamicity of quantum network links and the probabilistic nature of quantum operations. Consequently, designing hand-crafted heuristics is difficult and often leads to suboptimal performance, especially if global network topology information is unavailable. In this paper, we propose RELiQ, a reinforcement learning-based approach to entanglement routing that only relies on local information and iterative message exchange. Utilizing a graph neural network, RELiQ learns graph representations and avoids overfitting to specific network topologies - a prevalent issue for learning-based approaches. Our approach, trained on random graphs, consistently outperforms existing local information heuristics and learning-based approaches when applied to random and real-world topologies. When compared to global information heuristics, our method achieves similar or superior performance because of its rapid response to topology changes.

Biological and artificial learners are inherently exposed to a stream of data and experience throughout their lifetimes and must constantly adapt to, learn from, or selectively ignore the ongoing input. Recent findings reveal that, even when the performance remains stable, the underlying neural representations can change gradually over time, a phenomenon known as representational drift. Studying the different sources of data and noise that may contribute to drift is essential for understanding lifelong learning in neural systems. However, a systematic study of drift across architectures and learning rules, and the connection to task, are missing. Here, in an online learning setup, we characterize drift as a function of data distribution, and specifically show that the learning noise induced by task-irrelevant stimuli, which the agent learns to ignore in a given context, can create long-term drift in the representation of task-relevant stimuli. Using theory and simulations, we demonstrate this phenomenon both in Hebbian-based learning -- Oja's rule and Similarity Matching -- and in stochastic gradient descent applied to autoencoders and a supervised two-layer network. We consistently observe that the drift rate increases with the variance and the dimension of the data in the task-irrelevant subspace. We further show that this yields different qualitative predictions for the geometry and dimension-dependency of drift than those arising from Gaussian synaptic noise. Overall, our study links the structure of stimuli, task, and learning rule to representational drift and could pave the way for using drift as a signal for uncovering underlying computation in the brain.

Understanding human behavior and society is a central focus in social sciences, with the rise of generative social science marking a significant paradigmatic shift. By leveraging bottom-up simulations, it replaces costly and logistically challenging traditional experiments with scalable, replicable, and systematic computational approaches for studying complex social dynamics. Recent advances in large language models (LLMs) have further transformed this research paradigm, enabling the creation of human-like generative social agents and realistic simulacra of society. In this paper, we propose AgentSociety, a large-scale social simulator that integrates LLM-driven agents, a realistic societal environment, and a powerful large-scale simulation engine. Based on the proposed simulator, we generate social lives for over 10k agents, simulating their 5 million interactions both among agents and between agents and their environment. Furthermore, we explore the potential of AgentSociety as a testbed for computational social experiments, focusing on five key social issues: polarization, the spread of inflammatory messages, the effects of universal basic income policies, the impact of external shocks such as hurricanes, and urban sustainability. These five issues serve as valuable cases for assessing AgentSociety's support for typical research methods -- such as surveys, interviews, and interventions -- as well as for investigating the patterns, causes, and underlying mechanisms of social issues. The alignment between AgentSociety's outcomes and real-world experimental results not only demonstrates its ability to capture human behaviors and their underlying mechanisms, but also underscores its potential as an important platform for social scientists and policymakers.

Conformal prediction has emerged as a widely used framework for constructing valid prediction sets in classification and regression tasks. In this work, we extend the split conformal prediction framework to hierarchical classification, where prediction sets are commonly restricted to internal nodes of a predefined hierarchy, and propose two computationally efficient inference algorithms. The first algorithm returns internal nodes as prediction sets, while the second one relaxes this restriction. Using the notion of representation complexity, the latter yields smaller set sizes at the cost of a more general and combinatorial inference problem. Empirical evaluations on several benchmark datasets demonstrate the effectiveness of the proposed algorithms in achieving nominal coverage.

Coordination is a fundamental aspect of life. The advent of social media has made it integral also to online human interactions, such as those that characterize thriving online communities and social movements. At the same time, coordination is also core to effective disinformation, manipulation, and hate campaigns. This survey collects, categorizes, and critically discusses the body of work produced as a result of the growing interest on coordinated online behavior. We reconcile industry and academic definitions, propose a comprehensive framework to study coordinated online behavior, and review and critically discuss the existing detection and characterization methods. Our analysis identifies open challenges and promising directions of research, serving as a guide for scholars, practitioners, and policymakers in understanding and addressing the complexities inherent to online coordination.

Extranodal extension (ENE) is an emerging prognostic factor in human papillomavirus (HPV)-associated oropharyngeal cancer (OPC), although it is currently omitted as a clinical staging criteria. Recent works have advocated for the inclusion of iENE as a prognostic marker in HPV-positive OPC staging. However, several practical limitations continue to hinder its clinical integration, including inconsistencies in segmentation, low contrast in the periphery of metastatic lymph nodes on CT imaging, and laborious manual annotations. To address these limitations, we propose a fully automated end-to-end pipeline that uses computed tomography (CT) images with clinical data to assess the status of nodal ENE and predict treatment outcomes. Our approach includes a hierarchical 3D semi-supervised segmentation model designed to detect and delineate relevant iENE from radiotherapy planning CT scans. From these segmentations, a set of radiomics and deep features are extracted to train an imaging-detected ENE grading classifier. The predicted ENE status is then evaluated for its prognostic value and compared with existing staging criteria. Furthermore, we integrate these nodal features with primary tumor characteristics in a multimodal, attention-based outcome prediction model, providing a dynamic framework for outcome prediction. Our method is validated in an internal cohort of 397 HPV-positive OPC patients treated with radiation therapy or chemoradiotherapy between 2009 and 2020. For outcome prediction at the 2-year mark, our pipeline surpassed baseline models with 88.2% (4.8) in AUC for metastatic recurrence, 79.2% (7.4) for overall survival, and 78.1% (8.6) for disease-free survival. We also obtain a concordance index of 83.3% (6.5) for metastatic recurrence, 71.3% (8.9) for overall survival, and 70.0% (8.1) for disease-free survival, making it feasible for clinical decision making.

Von Economo neurons (VENs) are large bipolar projection neurons found exclusively in the anterior cingulate cortex (ACC) and frontal insula of species with complex social cognition, including humans, great apes, and cetaceans. Their selective depletion in frontotemporal dementia (FTD) and altered development in autism implicate them in rapid social decision-making, yet no computational model of VEN function has previously existed. We introduce the Fast Lane Hypothesis: VENs implement a biological speed-accuracy tradeoff (SAT) by providing a sparse, fast projection pathway that enables rapid social decisions at the cost of deliberate processing accuracy. We model VENs as fast leaky integrate-and-fire (LIF) neurons with membrane time constant 5 ms and sparse dendritic fan-in of eight afferents, compared to 20 ms and eighty afferents for standard pyramidal neurons, within a spiking cortical circuit of 2,000 neurons trained on a social discrimination task. Networks are evaluated under three clinically motivated conditions across 10 independent random seeds: typical (2% VENs), autism-like (0.4% VENs), and FTD-like (post-training VEN ablation). All configurations achieve equivalent asymptotic classification accuracy (99.4%), consistent with the prediction that VENs modulate decision speed rather than representational capacity. Temporal analysis confirms that VENs produce median first-spike latencies 4 ms earlier than pyramidal neurons. At a fixed decision threshold, the typical condition is significantly faster than FTD-like (t=-23.31, p<0.0001), while autism-like is intermediate (mean RT=26.91+/-9.01 ms vs. typical 20.70+/-2.02 ms; p=0.078). A preliminary evolutionary analysis shows qualitative correspondence between model-optimal VEN fraction and the primate phylogenetic gradient. To our knowledge, this is the first computational model that asks what a Von Economo neuron actually computes.

Image generative models have become indispensable tools to yield exquisite high-resolution (HR) images for everyone, ranging from general users to professional designers. However, a desired outcome often requires generating a large number of HR images with different prompts and seeds, resulting in high computational cost for both users and service providers. Generating low-resolution (LR) images first could alleviate computational burden, but it is not straightforward how to generate LR images that are perceptually consistent with their HR counterparts. Here, we consider the task of generating high-fidelity LR images, called Previews, that preserve perceptual similarity of their HR counterparts for an efficient workflow, allowing users to identify promising candidates before generating the final HR image. We propose the commutator-zero condition to ensure the LR-HR perceptual consistency for flow matching models, leading to the proposed training-free solution with downsampling matrix selection and commutator-zero guidance. Extensive experiments show that our method can generate LR images with up to 33\% computation reduction while maintaining HR perceptual consistency. When combined with existing acceleration techniques, our method achieves up to 3$\times$ speedup. Moreover, our formulation can be extended to image manipulations, such as warping and translation, demonstrating its generalizability.

We develop a predictive-first optimisation framework for streaming hidden Markov models. Unlike classical approaches that prioritise full posterior recovery under a fully specified generative model, we assume access to regime-specific predictive models whose parameters are learned online while maintaining a fixed transition prior over regimes. Our objective is to sequentially identify latent regimes while maintaining accurate step-ahead predictive distributions. Because the number of possible regime paths grows exponentially, exact filtering is infeasible. We therefore formulate streaming inference as a constrained projection problem in predictive-distribution space: under a fixed hypothesis budget, we approximate the full posterior predictive by the forward-KL optimal mixture supported on $S$ paths. The solution is the renormalised top-$S$ posterior-weighted mixture, providing a principled derivation of beam search for HMMs. The resulting algorithm is fully recursive and deterministic, performing beam-style truncation with closed-form predictive updates and requiring neither EM nor sampling. Empirical comparisons against Online EM and Sequential Monte Carlo under matched computational budgets demonstrate competitive prequential performance.

There is substantial concern about the ability of advanced artificial intelligence to influence people's behaviour. A rapidly growing body of research has found that AI can produce large persuasive effects on people's attitudes, but whether AI can persuade people to take consequential real-world actions has remained unclear. In two large preregistered experiments N=17,950 responses from 14,779 people), we used conversational AI models to persuade participants on a range of attitudinal and behavioural outcomes, including signing real petitions and donating money to charity. We found sizable AI persuasion effects on these behavioural outcomes (e.g. +19.7 percentage points on petition signing). However, we observed no evidence of a correlation between AI persuasion effects on attitudes and behaviour. Moreover, we replicated prior findings that information provision drove effects on attitudes, but found no such evidence for our behavioural outcomes. In a test of eight behavioural persuasion strategies, all outperformed the most effective attitudinal persuasion strategy, but differences among the eight were small. Taken together, these results suggest that previous findings relying on attitudinal outcomes may generalize poorly to behaviour, and therefore risk substantially mischaracterizing the real-world behavioural impact of AI persuasion.