Non-human primates are our closest living relatives, and analyzing their behavior is central to research in cognition, evolution, and conservation. Computer vision could greatly aid this research, but existing methods often rely on human-centric pretrained models and focus on single datasets, which limits generalization. We address this limitation by shifting from a model-centric to a data-centric approach and introduce PriVi, a large-scale primate-centric video pretraining dataset. PriVi contains 424 hours of curated video, combining 174 hours from behavioral research across 11 settings with 250 hours of diverse web-sourced footage, assembled through a scalable data curation pipeline. We continue pretraining V-JEPA, a large-scale video model, on PriVi to learn primate-specific representations and evaluate it using a lightweight frozen classifier. Across four benchmark datasets, ChimpACT, PanAf500, BaboonLand, and ChimpBehave, our approach consistently outperforms prior work, including fully finetuned baselines, and scales favorably with fewer labels. These results demonstrate for the first time that domain-level pretraining, where pretraining is conducted on similar data but not the target dataset itself, works for video models. Our primate-centric pretraining substantially improves data efficiency and generalization, making it a promising approach for low-label applications. Dataset, code, and models are available: https://privi.eckerlab.org

Mixture-of-Experts (MoE) architectures scale large language models (LLMs) by activating only a subset of experts per token, but the standard TopK routing assigns the same fixed number of experts to all tokens, ignoring their varying complexity. Prior adaptive routing methods introduce additional modules and hyperparameters, often requiring costly retraining from scratch. We propose Sequence-level TopK (SeqTopK), a minimal modification that shifts the expert budget from the token level to the sequence level. By selecting the top $T \cdot K$ experts across all $T$ tokens, SeqTopK enables end-to-end learned dynamic allocation -- assigning more experts to difficult tokens and fewer to easy ones -- while preserving the same overall budget. SeqTopK requires only a few lines of code, adds less than 1% overhead, and remains fully compatible with pretrained MoE models. Experiments across math, coding, law, and writing show consistent improvements over TopK and prior parameter-free adaptive methods, with gains that become substantially larger under higher sparsity (up to 16.9%). These results highlight SeqTopK as a simple, efficient, and scalable routing strategy, particularly well-suited for the extreme sparsity regimes of next-generation LLMs. Code is available at https://github.com/Y-Research-SBU/SeqTopK.

Constructing a consistent shared spatial memory is a critical challenge in multi-agent systems, where partial observability and limited bandwidth often lead to catastrophic failures in coordination. We introduce a multi-agent predictive coding framework that formulates coordination as the minimization of mutual uncertainty among agents. Through an information bottleneck objective, this framework prompts agents to learn not only who and what to communicate but also when. At the foundation of this framework lies a grid-cell-like metric as internal spatial coding for self-localization, emerging spontaneously from self-supervised motion prediction. Building upon this internal spatial code, agents gradually develop a bandwidth-efficient communication mechanism and specialized neural populations that encode partners' locations-an artificial analogue of hippocampal social place cells (SPCs). These social representations are further utilized by a hierarchical reinforcement learning policy that actively explores to reduce joint uncertainty. On the Memory-Maze benchmark, our approach shows exceptional resilience to bandwidth constraints: success degrades gracefully from 73.5% to 64.4% as bandwidth shrinks from 128 to 4 bits/step, whereas a full-broadcast baseline collapses from 67.6% to 28.6%. Our findings establish a theoretically principled and biologically plausible basis for how complex social representations emerge from a unified predictive drive, leading to collective intelligence.

Healthcare artificial intelligence systems often degrade in performance when deployed across institutions, with documented performance drops and perpetuation of discriminatory patterns embedded in data. This brittleness comes, in part, from learning statistical associations rather than causal mechanisms. Causal graph neural networks address this by combining graph-based representations of biomedical data with causal inference to learn invariant mechanisms instead of just spurious correlations. This Perspective reviews the methodology of structural causal models, disentangled causal representation learning, and techniques for interventional prediction and counterfactual reasoning on graphs. We discuss applications across psychiatric diagnosis and brain network analysis, cancer subtyping with multi-omics causal integration, continuous physiological monitoring, and drug recommendations. These methods provide building blocks for patient-specific Causal Digital Twins that could support in silico clinical experimentation. Remaining challenges include computational costs that preclude real-time deployment, validation challenges that go beyond standard cross-validation, and the risk of causal-washing where methods adopt causal terminology without rigorous evidentiary support. We propose a tiered framework distinguishing causally-inspired architectures from causally-validated discoveries and outline future directions, including scalable causal discovery, multi-modal data integration, and regulatory pathways for these methods. Making practical Causal Digital Twins possible will require an honest assessment of what current methods deliver, sustained collaboration across disciplines, and validation standards that match the strength of the causal claims being made.

Graphical user interface (GUI) grounding is a key capability for computer-use agents, mapping natural-language instructions to actionable regions on the screen. Existing Multimodal Large Language Model (MLLM) approaches typically formulate GUI grounding as a text-based coordinate generation task. However, directly generating precise coordinates from visual inputs is challenging and often data-intensive. A more intuitive strategy is to first identify instruction-relevant visual patches and then determine the exact click location within them. Motivated by recent observations that general MLLMs exhibit native grounding ability embedded in their attention maps, we propose GUI-AIMA, an attention-based and coordinate-free supervised fine-tuning framework for efficient GUI grounding. GUI-AIMA aligns the intrinsic multimodal attention of MLLMs with patch-wise grounding signals. These signals are calculated adaptively for diverse user instructions by multi-head aggregation on simplified query-visual attention matrices. Besides, its coordinate-free manner can easily integrate a plug-and-play zoom-in stage. GUI-AIMA-3B was trained with only 509k samples (around 101k screenshots), demonstrating exceptional data efficiency and verifying that light training can trigger the native grounding capability of MLLMs. It achieves state-of-the-art performance among 3B models, attaining an average accuracy of 61.5% on ScreenSpot-Pro, 92.1% on ScreenSpot-v2, 68.1% on OSWorld-G, 79.1% on MMBench-GUI-L2, and 60.0% on UI-Vision. Project page: https://github.com/sjz5202/GUI-AIMA

In entomology and ecology research, biologists often need to collect a large number of insects, among which beetles are the most common species. A common practice for biologists to organize beetles is to place them on trays and take a picture of each tray. Given the images of thousands of such trays, it is important to have an automated pipeline to process the large-scale data for further research. Therefore, we develop a 3-stage pipeline to detect all the beetles on each tray, sort and crop the image of each beetle, and do morphological segmentation on the cropped beetles. For detection, we design an iterative process utilizing a transformer-based open-vocabulary object detector and a vision-language model. For segmentation, we manually labeled 670 beetle images and fine-tuned two variants of a transformer-based segmentation model to achieve fine-grained segmentation of beetles with relatively high accuracy. The pipeline integrates multiple deep learning methods and is specialized for beetle image processing, which can greatly improve the efficiency to process large-scale beetle data and accelerate biological research.

Despite their impressive realism, modern text-to-image models still struggle with compositionality, often failing to render accurate object counts, attributes, and spatial relations. To address this challenge, we present a training-free framework that combines an object-centric approach with self-refinement to improve layout faithfulness while preserving aesthetic quality. Specifically, we leverage large language models (LLMs) to synthesize explicit layouts from input prompts, and we inject these layouts into the image generation process, where a object-centric vision-language model (VLM) judge reranks multiple candidates to select the most prompt-aligned outcome iteratively. By unifying explicit layout-grounding with self-refine-based inference-time scaling, our framework achieves stronger scene alignment with prompts compared to recent text-to-image models. The code are available at https://github.com/gcl-inha/ReFocus.

Automating chicken shoulder deboning requires precise 6-DoF cutting through a partially occluded, deformable, multi-material joint, since contact with the bones presents serious health and safety risks. Our work makes both systems-level and algorithmic contributions to train and deploy a reactive force-feedback cutting policy that dynamically adapts a nominal trajectory and enables full 6-DoF knife control to traverse the narrow joint gap while avoiding contact with the bones. First, we introduce an open-source custom-built simulator for multi-material cutting that models coupling, fracture, and cutting forces, and supports reinforcement learning, enabling efficient training and rapid prototyping. Second, we design a reusable physical testbed to emulate the chicken shoulder: two rigid "bone" spheres with controllable pose embedded in a softer block, enabling rigorous and repeatable evaluation while preserving essential multi-material characteristics of the target problem. Third, we train and deploy a residual RL policy, with discretized force observations and domain randomization, enabling robust zero-shot sim-to-real transfer and the first demonstration of a learned policy that debones a real chicken shoulder. Our experiments in our simulator, on our physical testbed, and on real chicken shoulders show that our learned policy reliably navigates the joint gap and reduces undesired bone/cartilage contact, resulting in up to a 4x improvement over existing open-loop cutting baselines in terms of success rate and bone avoidance. Our results also illustrate the necessity of force feedback for safe and effective multi-material cutting. The project website is at https://hal-zhaodong-yang.github.io/MultiMaterialWebsite/.

Domain shift in histopathology, often caused by differences in acquisition processes or data sources, poses a major challenge to the generalization ability of deep learning models. Existing methods primarily rely on modeling statistical correlations by aligning feature distributions or introducing statistical variation, yet they often overlook causal relationships. In this work, we propose a novel causal-inference-based framework that leverages semantic features while mitigating the impact of confounders. Our method implements the front-door principle by designing transformation strategies that explicitly incorporate mediators and observed tissue slides. We validate our method on the CAMELYON17 dataset and a private histopathology dataset, demonstrating consistent performance gains across unseen domains. As a result, our approach achieved up to a 7% improvement in both the CAMELYON17 dataset and the private histopathology dataset, outperforming existing baselines. These results highlight the potential of causal inference as a powerful tool for addressing domain shift in histopathology image analysis.

We present a neural parametric 3D breast shape model and, based on this model, introduce a low-cost and accessible 3D surface reconstruction pipeline capable of recovering accurate breast geometry from a monocular RGB video. In contrast to widely used, commercially available yet prohibitively expensive 3D breast scanning solutions and existing low-cost alternatives, our method requires neither specialized hardware nor proprietary software and can be used with any device that is able to record RGB videos. The key building blocks of our pipeline are a state-of-the-art, off-the-shelf Structure-from-motion pipeline, paired with a parametric breast model for robust and metrically correct surface reconstruction. Our model, similarly to the recently proposed implicit Regensburg Breast Shape Model (iRBSM), leverages implicit neural representations to model breast shapes. However, unlike the iRBSM, which employs a single global neural signed distance function (SDF), our approach -- inspired by recent state-of-the-art face models -- decomposes the implicit breast domain into multiple smaller regions, each represented by a local neural SDF anchored at anatomical landmark positions. When incorporated into our surface reconstruction pipeline, the proposed model, dubbed liRBSM (short for localized iRBSM), significantly outperforms the iRBSM in terms of reconstruction quality, yielding more detailed surface reconstruction than its global counterpart. Overall, we find that the introduced pipeline is able to recover high-quality 3D breast geometry within an error margin of less than 2 mm. Our method is fast (requires less than six minutes), fully transparent and open-source, and -- together with the model -- publicly available at https://rbsm.re-mic.de/local-implicit.

Instruction-guided video editing has emerged as a rapidly advancing research direction, offering new opportunities for intuitive content transformation while also posing significant challenges for systematic evaluation. Existing video editing benchmarks fail to support the evaluation of instruction-guided video editing adequately and further suffer from limited source diversity, narrow task coverage and incomplete evaluation metrics. To address the above limitations, we introduce IVEBench, a modern benchmark suite specifically designed for instruction-guided video editing assessment. IVEBench comprises a diverse database of 600 high-quality source videos, spanning seven semantic dimensions, and covering video lengths ranging from 32 to 1,024 frames. It further includes 8 categories of editing tasks with 35 subcategories, whose prompts are generated and refined through large language models and expert review. Crucially, IVEBench establishes a three-dimensional evaluation protocol encompassing video quality, instruction compliance and video fidelity, integrating both traditional metrics and multimodal large language model-based assessments. Extensive experiments demonstrate the effectiveness of IVEBench in benchmarking state-of-the-art instruction-guided video editing methods, showing its ability to provide comprehensive and human-aligned evaluation outcomes.

Semantic segmentation is essential for automating remote sensing analysis in fields like ecology. However, fine-grained analysis of complex aerial or underwater imagery remains an open challenge, even for state-of-the-art models. Progress is frequently hindered by the high cost of obtaining the dense, expert-annotated labels required for model supervision. While sparse point-labels are easier to obtain, they introduce challenges regarding which points to annotate and how to propagate the sparse information. We present SSeg, a novel framework that addresses both issues. SSeg first employs an active sampling strategy to guide annotators, maximizing the value of their point labels. Then, it propagates these sparse labels with a hybrid approach leveraging both the best of SAM2 and superpixel-based methods. Experiments on two diverse monitoring datasets demonstrate SSeg's benefits over state-of-the-art approaches. Our main contribution is a simple but effective interactive annotation tool integrating our algorithms. It enables ecology researchers to leverage foundation models and computer vision to efficiently generate high-quality segmentation masks to process their data.

Maintaining an up-to-date map that accurately reflects recent changes in the environment is crucial, especially for robots that repeatedly traverse the same space. Failing to promptly update the changed regions can degrade map quality, resulting in poor localization, inefficient operations, and even lost robots. 3D Gaussian Splatting (3DGS) has recently seen widespread adoption in online map reconstruction due to its dense, differentiable, and photorealistic properties, yet accurately and efficiently updating the regions of change remains a challenge. In this paper, we propose VG-Mapping, a novel online 3DGS-based mapping system tailored for such semi-static scenes. Our approach introduces a variation-aware density control strategy that decouples Gaussian density regulation from optimization. Specifically, we identify regions with variation to guide initialization and pruning, which avoids the use of stale information in defining the starting point for the subsequent optimization. Furthermore, to address the absence of public benchmarks for this task, we construct a RGB-D dataset comprising both synthetic and real-world semi-static environments. Experimental results demonstrate that our method substantially improves the rendering quality and map update efficiency in semi-static scenes. The code and dataset are available at https://github.com/heyicheng-never/VG-Mapping.

Due to their inherent complexity, reasoning tasks have long been regarded as rigorous benchmarks for assessing the capabilities of machine learning models, especially large language models (LLMs). Although humans can solve these tasks with ease, existing models, even after extensive pre-training and post-training at scale, still fail to perform reasoning reliably. In this paper, we revisit reasoning tasks from a causal perspective, seeking to understand their behavior in latent space and to offer insights for addressing their challenges. Specifically, we cast reasoning tasks as a selection mechanism, in which high-level logical concepts function as selection operators on the given observations, such as, identifying the correct answer in a math problem or filling the appropriate entry in Sudoku. We emphasize two key properties of this formulation that shed light on the difficulty of reasoning tasks. First, the latent space exceeds the observation space in complexity, even when the correct answer is fully determined by the observed input. Second, the latent variables, corresponding to logical thought, are densely structured and exhibit strong dependencies. Building on this formulation, we introduce a framework, called SR$^2$, that incorporates the estimated latent variables as feedback into the selection mechanism, thereby facilitating the learning of dense dependencies among latent representations. The framework consists of three key modules: reflective representation learning, dependency self-refinement, and periodic intermediate alignment. Experimentally, we show that our approach yields significant gains in reasoning accuracy, for example, attaining over 10$\%$ improvement in performance with 8$\times$ fewer parameters on the Sudoku and Maze tasks over the recent advances.

Fixed-wing unmanned aerial vehicles (UAVs) offer endurance and efficiency but lack low-speed agility due to highly coupled dynamics. We present an end-to-end sensing-to-control pipeline that combines bio-inspired hardware, physics-informed dynamics learning, and convex control allocation. Measuring airflow on a small airframe is difficult because near-body aerodynamics, propeller slipstream, control-surface actuation, and ambient gusts distort pressure signals. Inspired by the narwhal's protruding tusk, we mount in-house multi-hole probes far upstream and complement them with sparse, carefully placed wing pressure sensors for local flow measurement. A data-driven calibration maps probe pressures to airspeed and flow angles. We then learn a control-affine dynamics model using the estimated airspeed/angles and sparse sensors. A soft left/right symmetry regularizer improves identifiability under partial observability and limits confounding between wing pressures and flaperon inputs. Desired wrenches (forces and moments) are realized by a regularized least-squares allocator that yields smooth, trimmed actuation. Wind-tunnel studies across a wide operating range show that adding wing pressures reduces force-estimation error by 25-30%, the proposed model degrades less under distribution shift (about 12% versus 44% for an unstructured baseline), and force tracking improves with smoother inputs, including a 27% reduction in normal-force RMSE versus a plain affine model and 34% versus an unstructured baseline.

Deep Neural Networks (DNNs) have attracted significant attention, and their internal models are now considered valuable intellectual assets. Extracting such a model via oracle access to a DNN is conceptually similar to extracting a secret key from a block cipher. Consequently, cryptanalytic techniques, particularly differential-like attacks, have been actively explored. ReLU-based DNNs are the most common and widely deployed architectures. While early works (e.g., Crypto 2020, Eurocrypt 2024) assume access to exact output logits, which are typically not exposed, more recent works (e.g., Asiacrypt 2024, Eurocrypt 2025) focus on the hard-label setting, where only the final classification result (e.g., "dog" or "car") is available. Notably, Carlini et al. (Eurocrypt 2025) showed that model extraction is feasible in polynomial time even under this restricted setting. In this paper, we show that a key assumption underlying their attack becomes increasingly unrealistic as the target depth grows. While prior works noted neurons whose activation states rarely change, we analyze their concrete impact on hard-label extraction: even a single neuron that is (almost) always active can prevent the attack from proceeding unless its parameters are recovered, and ignoring it incurs a non-negligible error. A straightforward solution is to extract these parameters by observing a state switch of such a neuron, but observing such a switch becomes exponentially harder as depth increases, implying that hard-label extraction is not always polynomial time. To address this limitation, we propose a novel attack called cross-layer extraction. Rather than extracting secret parameters (e.g., weights and biases) directly, we exploit cross-layer interactions to recover them from deeper layers, reducing query complexity and addressing limitations of existing approaches.

Bayesian optimization (BO) is effective for expensive black-box problems but remains challenging in high dimensions. We propose NeST-BO, a curvature-aware local BO method that targets a (modified) Newton step by jointly learning gradient and Hessian information with Gaussian process (GP) surrogates, and selecting evaluations via a one-step lookahead bound on the Newton-step error. We show that this bound contracts with batch size, so NeST-BO drives the step error to zero; in well-behaved neighborhoods it recovers the fast local convergence behavior of inexact/modified Newton methods, while standard safeguards support global convergence to stationary points. To improve scaling with problem dimension, we optimize the acquisition in low-dimensional embedded subspaces (random or learned), reducing the dominant cost of learning curvature from $O(d^2)$ to $O(m^2)$ with $m \ll d$ while preserving step targeting. Across high-dimensional synthetic and real-world problems, including cases with thousands of variables and unknown active subspaces, NeST-BO consistently yields faster convergence and better final values than state-of-the-art local and high-dimensional BO baselines.

Effectively applying Vision-Language Models (VLMs) to Video Question Answering (VideoQA) hinges on selecting a concise yet comprehensive set of frames, as processing entire videos is computationally infeasible. However, current frame selection methods face a critical trade-off: approaches relying on lightweight similarity models, such as CLIP, often fail to capture the nuances of complex queries, resulting in inaccurate similarity scores that cannot reflect the authentic query-frame relevance, which further undermines frame selection. Meanwhile, methods that leverage a VLM for deeper analysis achieve higher accuracy but incur prohibitive computational costs. To address these limitations, we propose A.I.R., a training-free approach for Adaptive, Iterative, and Reasoning-based frame selection. We leverage a powerful VLM to perform deep, semantic analysis on complex queries, and this analysis is deployed within a cost-effective iterative loop that processes only a small batch of the most high-potential frames at a time. Extensive experiments on various VideoQA benchmarks demonstrate that our approach outperforms existing frame selection methods, significantly boosts the performance of the foundation VLM, and achieves substantial gains in computational efficiency over other VLM-based techniques.

Large Language Models (LLMs) tend to generate a long reasoning chain when solving complex tasks. However, as the reasoning chain extends, critical intermediate steps and the original prompt will be buried in the context, receiving insufficient attention and leading to errors. In this work, we present ATAR, a novel reasoning method that leverages the inherent reasoning structure to steer LLM attention. Our experiments show that ATAR outperforms SOTA methods across six benchmarks, achieving up to 15.39% absolute improvement. Furthermore, with ATAR, "non-reasoning" models achieve comparable or even better performance compared to reasoning models of the same size in most benchmarks. Finally, our ablation studies show that the attention alignment component contributes significantly, and that these improvements are persist under different attentionsteering backends.

Zero-shot captioners are recently proposed models that utilize common-space vision-language representations to caption images without relying on paired image-text data. To caption an image, they proceed by textually decoding a text-aligned image feature, but they limit their scope to global representations and whole-image captions. We present a unified framework for zero-shot captioning that shifts from an image-centric to a patch-centric paradigm, enabling the captioning of arbitrary regions without the need of region-level supervision. Instead of relying on global image representations, we treat individual patches as atomic captioning units and aggregate them to describe arbitrary regions, from single patches to non-contiguous areas and entire images. We analyze the key ingredients that enable current latent captioners to work in our novel proposed framework. Experiments demonstrate that backbones producing meaningful, dense visual features, such as DINO, are key to achieving state-of-the-art performance in multiple region-based captioning tasks. Compared to other baselines and state-of-the-art competitors, our models achieve better performance on zero-shot dense captioning and region-set captioning. We also introduce a new trace captioning task that further demonstrates the effectiveness of patch-wise semantic representations for flexible caption generation. Project page at https://paciosoft.com/Patch-ioner/ .

Worldwide visual geo-localization aims to determine the geographic location of an image anywhere on Earth using only its visual content. Despite recent progress, learning expressive representations of geographic space remains challenging due to the inherently low-dimensional nature of geographic coordinates. We formulate global geo-localization as aligning the visual representation of a query image with a learned geographic representation. Our approach explicitly models the world as a hierarchy of learned geographic embeddings, enabling a distributed and multi-scale representation of geographic space. In addition, we introduce a semantic fusion module that efficiently integrates appearance features with semantic segmentation through latent cross-attention, producing a more robust visual representation for localization. Experiments on five widely used geo-localization benchmarks demonstrate that our method achieves new state-of-the-art results on 22 of 25 reported metrics. Ablation studies show that these improvements are primarily driven by the proposed geographic representation and semantic fusion mechanism.

Identifying wireless modulation schemes is essential for cognitive radio, but standard supervised models often degrade under distribution shift, and training domain-specific wireless foundation models from scratch is computationally prohibitive. Large Language Models (LLMs) offer a promising training-free alternative via in-context learning, yet feeding raw floating-point signal statistics into LLMs overwhelms models with numerical noise and exhausts token budgets. We introduce DiSC-AMC, a framework that reformulates Automatic Modulation Classification (AMC) as an LLM reasoning task by combining aggressive feature discretization with nearest-neighbor retrieval over self-supervised embeddings. By mapping continuous features to coarse symbolic tokens, DiSC-AMC aligns abstract signal patterns with LLM reasoning capabilities and reduces prompt length by over $50$\%. Simultaneously, utilizing a DINOv2 visual encoder to retrieve the $k_\text{NN}$ most similar labeled exemplars provides highly relevant, query-specific context rather than generic class averages. On a 10-class benchmark, a fine-tuned 7B-parameter LLM using DiSC-AMC achieves $83.0$\% in-distribution accuracy ($-10$\,to\,$+10$\,dB) and $82.50$\% out-of-distribution (OOD) accuracy ($-11$\,to\,$-15$\,dB), outperforming supervised baselines. Comprehensive ablations on vanilla LLMs demonstrate the token efficiency of DiSC-AMC. A training-free $7$B LLM achieves $71$\% accuracy using only $0.5$\,K-token prompt,surpassing a $200$B-parameter baseline that relies on a $2.9$K-token prompt. Furthermore, similarity-based exemplar retrieval outperforms naive class-average selection by over $20$\%. Finally, we identify a fundamental limitation of this pipeline. At extreme OOD noise levels ($-30$\,dB), the underlying self-supervised representations collapse, degrading retrieval quality and reducing classification to random chance.

Molecular Dynamics (MD) is a powerful computational microscope for probing protein functions. However, the need for fine-grained integration and the long timescales of biomolecular events make MD computationally expensive. To address this, several generative models have been proposed to generate surrogate trajectories at lower cost. Yet, these models typically learn a fixed-lag transition density, causing the training signal to be dominated by frequent but uninformative transitions. We introduce a new class of generative models, MSM Emulators, which instead learn to sample transitions across discrete states defined by an underlying Markov State Model (MSM). We instantiate this class with Markov Space Flow Matching (MarS-FM), whose sampling offers more than two orders of magnitude speedup compared to implicit- or explicit-solvent MD simulations. We benchmark Mars-FM ability to reproduce MD statistics through structural observables such as RMSD, radius of gyration, and secondary structure content. Our evaluation spans protein domains (up to 500 residues) with significant chemical and structural diversity, including unfolding events, and enforces strict sequence dissimilarity between training and test sets to assess generalization. Across all metrics, MarS-FM outperforms existing methods, often by a substantial margin.

Online alignment (e.g., GRPO) is generally more performant than offline alignment (e.g., DPO) -- but why? Drawing on prospect theory from behavioral economics, we propose a human-centric explanation. We prove that online on-policy sampling better approximates the human-perceived distribution of what the model can produce, and PPO/GRPO-style clipping -- originally introduced to just stabilize training -- recovers a perceptual bias in how humans perceive probability. In this sense, PPO/GRPO act as perceptual losses already. Our theory further suggests that the online/offline dichotomy is itself incidental to maximizing human utility, since we can achieve the same effect by selectively training on any data in a manner that mimics human perception, rather than restricting ourselves to online on-policy data. Doing so would allow us to post-train more quickly, cheaply, and flexibly without sacrificing performance. To this end, we propose a design pattern that explicitly incorporates perceptual distortions of probability into objectives like DPO/KTO/GRPO, creating humanline variants of them. Surprisingly, we find that these humanline variants, even when trained with offline off-policy data, can match the performance of their online counterparts (on both verifiable and unverifiable tasks) while running up to 6x faster.

Lifting 2D open-vocabulary understanding into 3D Gaussian Splatting (3DGS) scenes is a critical challenge. Mainstream methods, built on an embedding paradigm, suffer from three key flaws: (i) geometry-semantic inconsistency, where points, rather than objects, serve as the semantic basis, limiting semantic fidelity; (ii) semantic bloat from injecting gigabytes of feature data into the geometry; and (iii) semantic rigidity, as one feature per Gaussian struggles to capture rich polysemy. To overcome these limitations, we introduce ExtrinSplat, a framework built on the extrinsic paradigm that decouples geometry from semantics. Instead of embedding features, ExtrinSplat clusters Gaussians into multi-granularity, overlapping 3D object groups. A Vision-Language Model (VLM) then interprets these groups to generate lightweight textual hypotheses, creating an extrinsic index layer that natively supports complex polysemy. By replacing costly feature embedding with lightweight indices, ExtrinSplat reduces scene adaptation time from hours to minutes and lowers storage overhead by several orders of magnitude. On benchmark tasks for open-vocabulary 3D object selection and semantic segmentation, ExtrinSplat outperforms established embedding-based frameworks, validating the efficacy and efficiency of the proposed extrinsic paradigm.

Limited-angle computed tomography (LACT) offers improved temporal resolution and reduced radiation dose for cardiac imaging, but suffers from severe artifacts due to truncated projections. To address the ill-posedness of LACT reconstruction, we propose a two-stage diffusion framework guided by structured clinical metadata. In the first stage, a transformer-based diffusion model conditioned exclusively on metadata, including acquisition parameters, patient demographics, and diagnostic impressions, generates coarse anatomical priors from noise. The second stage further refines the images by integrating both the coarse prior and metadata to produce high-fidelity results. Physics-based data consistency is enforced at each sampling step in both stages using an Alternating Direction Method of Multipliers module, ensuring alignment with the measured projections. Extensive experiments on both synthetic and real cardiac CT datasets demonstrate that incorporating metadata significantly improves reconstruction fidelity, particularly under severe angular truncation. Compared to existing metadata-free baselines, our method achieves superior performance in SSIM, PSNR, nMI, and PCC. Ablation studies confirm that different types of metadata contribute complementary benefits, particularly diagnostic and demographic priors under limited-angle conditions. These findings highlight the dual role of clinical metadata in improving both reconstruction quality and efficiency, supporting their integration into future metadata-guided medical imaging frameworks.

The growing number of generative AI-based dialogue systems has made their evaluation a crucial challenge. This paper presents our contribution to this important problem through the Dialogue System Technology Challenge (DSTC-12, Track 1), where we developed models to predict dialogue-level, dimension-specific scores. Given the constraint of using relatively small models (i.e. fewer than 13 billion parameters) our work follows two main strategies: employing Language Models (LMs) as evaluators through prompting, and training encoder-based classification and regression models. Our results show that while LM prompting achieves only modest correlations with human judgments, it still ranks second on the test set, outperformed only by the baseline. The regression and classification models, with significantly fewer parameters, demonstrate high correlation for some dimensions on the validation set. Although their performance decreases on the test set, it is important to note that the test set contains annotations with significantly different score ranges for some of the dimensions with respect to the train and validation sets.

Designing therapeutic peptides with tailored properties is hindered by the vastness of sequence space, limited experimental data, and poor interpretability of current generative models. To address these challenges, we introduce PepThink-R1, a generative framework that integrates large language models (LLMs) with chain-of-thought (CoT) supervised fine-tuning and reinforcement learning (RL). Unlike prior approaches, PepThink-R1 explicitly reasons about monomer-level modifications during sequence generation, enabling interpretable design choices while optimizing for multiple pharmacological properties. Guided by a tailored reward function balancing chemical validity and property improvements, the model autonomously explores diverse sequence variants. We demonstrate that PepThink-R1 generates cyclic peptides with significantly enhanced lipophilicity, stability, and exposure, outperforming existing general LLMs (e.g., GPT-5) and domain-specific baseline in both optimization success and interpretability. To our knowledge, this is the first LLM-based peptide design framework that combines explicit reasoning with RL-driven property control, marking a step toward reliable and transparent peptide optimization for therapeutic discovery.

Attitude control is a fundamental aspect of spacecraft operations. Model Predictive Control (MPC) has emerged as a powerful strategy for these tasks, relying on accurate models of the system dynamics to optimize control actions over a prediction horizon. In scenarios where physics models are incomplete, difficult to derive, or computationally expensive, machine learning offers a flexible alternative by learning the system behavior directly from data. However, purely data-driven models often struggle with generalization and stability, especially when applied to inputs outside their training domain. To address these limitations, we investigate the benefits of incorporating Physics-Informed Neural Networks (PINNs) into the learning of spacecraft attitude dynamics, comparing their performance with that of purely data-driven approaches. Using a Real-valued Non-Volume Preserving (Real NVP) neural network architecture with a self-attention mechanism, we trained several models on simulated data generated with the Basilisk simulator. Two training strategies were considered: a purely data-driven baseline and a physics-informed variant to improve robustness and stability. Our results demonstrate that the inclusion of physics-based information significantly enhances the performance in terms of the mean relative error with the best architectures found by 27.08%. These advantages are particularly evident when the learned models are integrated into an MPC framework, where PINN-based models consistently outperform their purely data-driven counterparts in terms of control accuracy and robustness, and achieve improved settling times when compared to traditional MPC approaches, yielding improvements of up to 62%, when subject to observation noise and RWs friction.

Pre-trained Vision-Language Models (VLMs) struggle with Zero-Shot Anomaly Detection (ZSAD) due to a critical adaptation gap: they lack the local inductive biases required for dense prediction and employ inflexible feature fusion paradigms. We address these limitations through an Architectural Co-Design framework that jointly refines feature representation and cross-modal fusion. Our method proposes a parameter-efficient Convolutional Low-Rank Adaptation (Conv-LoRA) adapter to inject local inductive biases for fine-grained representation, and introduces a Dynamic Fusion Gateway (DFG) that leverages visual context to adaptively modulate text prompts, enabling a powerful bidirectional fusion. Extensive experiments on diverse industrial and medical benchmarks demonstrate superior accuracy and robustness, validating that this synergistic co-design is critical for robustly adapting foundation models to dense perception tasks. The source code is available at https://github.com/cockmake/ACD-CLIP.