Concept learning is a form of supervised machine learning that operates on knowledge bases in description logics. State-of-the-art concept learners often rely on an iterative search through a countably infinite concept space. In each iteration, they retrieve instances of candidate solutions to select the best concept for the next iteration. While simple learning problems might require a few dozen instance retrieval calls to find a fitting solution, complex learning problems might necessitate thousands of calls. We alleviate the resulting runtime challenge by presenting a semantics-aware caching approach. Our cache is essentially a subsumption-aware map that links concepts to a set of instances via crisp set operations. Our experiments on 5 datasets with 4 symbolic reasoners, a neuro-symbolic reasoner, and 5 popular pagination policies demonstrate that our cache can reduce the runtime of concept retrieval and concept learning by an order of magnitude while being effective for both symbolic and neuro-symbolic reasoners.

Recent breakthroughs in artificial intelligence through foundation models and agents have accelerated the evolution of computational pathology. Demonstrated performance gains reported across academia in benchmarking datasets in predictive tasks such as diagnosis, prognosis, and treatment response have ignited substantial enthusiasm for clinical application. Despite this development momentum, real world adoption has lagged, as implementation faces economic, technical, and administrative challenges. Beyond existing discussions of technical architectures and comparative performance, this review considers how these emerging AI systems can be responsibly integrated into medical practice by connecting deployable clinical relevance with downstream analytical capabilities and their technical maturity, operational readiness, and economic and regulatory context. Drawing on perspectives from an international group, we provide a practical assessment of current capabilities and barriers to adoption in patient care settings.

This paper studies how parents want to moderate children's interactions with Generative AI chatbots, with the goal of informing the design of future GenAI parental control tools. We first used an LLM to generate synthetic child-GenAI chatbot interaction scenarios and worked with four parents to validate their realism. From this dataset, we carefully selected 12 diverse examples that evoked varying levels of concern and were rated the most realistic. Each example included a prompt and a GenAI chatbot response. We presented these to parents (N=24) and asked whether they found them concerning, why, and how they would prefer the responses to be modified and communicated. Our findings reveal three key insights: (1) parents express concern about interactions that current GenAI chatbot parental controls neglect; (2) parents want fine-grained transparency and moderation at the conversation level; and (3) parents need personalized controls that adapt to their desired strategies and children's ages.

Solving constraints involving inductive (aka recursive) definitions is challenging. State-of-the-art SMT/CHC solvers and first-order logic provers provide only limited support for solving such constraints, especially when they involve, e.g., abstract data types. In this work, we leverage structured prompts to elicit Large Language Models (LLMs) to generate auxiliary lemmas that are necessary for reasoning about these inductive definitions. We further propose a neuro-symbolic approach, which synergistically integrates LLMs with constraint solvers: the LLM iteratively generates conjectures, while the solver checks their validity and usefulness for proving the goal. We evaluate our approach on a diverse benchmark suite comprising constraints originating from algebrai data types and recurrence relations. The experimental results show that our approach can improve the state-of-the-art SMT and CHC solvers, solving considerably more (around 25%) proof tasks involving inductive definitions, demonstrating its efficacy.

Large language models are increasingly deployed as cooperating agents, yet their behavior in adversarial consensus settings has not been systematically studied. We evaluate LLM-based agents on a Byzantine consensus game over scalar values using a synchronous all-to-all simulation. We test consensus in a no-stake setting where agents have no preferences over the final value, so evaluation focuses on agreement rather than value optimality. Across hundreds of simulations spanning model sizes, group sizes, and Byzantine fractions, we find that valid agreement is not reliable even in benign settings and degrades as group size grows. Introducing a small number of Byzantine agents further reduces success. Failures are dominated by loss of liveness, such as timeouts and stalled convergence, rather than subtle value corruption. Overall, the results suggest that reliable agreement is not yet a dependable emergent capability of current LLM-agent groups even in no-stake settings, raising caution for deployments that rely on robust coordination.

Finding optimal measurement operators is crucial for the performance of quantum reservoir computers (QRCs), since they employ a fixed quantum feature map. We formulate the training of both stateless (quantum extreme learning machines, QELMs) and stateful (memory dependent) QRCs in the framework of kernel ridge regression. We thus extend the kernel viewpoint of supervised quantum models to recurrent QRCs by deriving an exact Hilbert--Schmidt kernel representation of the optimal readout observable on history space. This approach renders an optimal measurement operator that minimizes prediction error for a given reservoir and training dataset. For large qubit numbers, this method is more efficient than the conventional training of QRCs. We discuss efficiency and practical implementation strategies, including Pauli basis decomposition and operator diagonalization, to adapt the optimal observable to hardware constraints. To demonstrate the effectiveness of this approach, we present numerical experiments on image classification and time series prediction tasks, including chaotic and strongly non-Markovian systems. The developed method can also be applied to other quantum machine learning models.

In real-world documents, the information relevant to a user query may reside anywhere from the beginning to the end. This makes position bias -- a systematic tendency of retrieval models to favor or neglect content based on its location -- a critical concern. Although recent studies have identified such bias, existing analyses focus predominantly on English, fail to disentangle document length from information position, and lack a standardized framework for systematic diagnosis. To address these limitations, we introduce PosIR (Position-Aware Information Retrieval), the first standardized benchmark designed to systematically diagnose position bias in diverse retrieval scenarios. PosIR comprises 310 datasets spanning 10 languages and 31 domains, with relevance tied to precise reference spans. At its methodological core, PosIR employs a length-controlled bucketing strategy that groups queries by positive document length and analyzes positional effects within each bucket. This design strictly isolates position bias from length-induced performance degradation. Extensive experiments on 10 state-of-the-art embedding-based retrieval models reveal that: (1) retrieval performance on PosIR with documents exceeding 1536 tokens correlates poorly with the MMTEB benchmark, exposing limitations of current short-text evaluations; (2) position bias is pervasive in embedding models and even increases with document length, with most models exhibiting primacy bias while certain models show unexpected recency bias; (3) as an exploratory investigation, gradient-based saliency analysis further uncovers two distinct internal mechanisms that correlate with these positional preferences. We hope that PosIR can serve as a valuable diagnostic framework to advance the development of position-robust retrieval systems.

We consider the densest submatrix problem, which seeks the submatrix of fixed size of a given binary matrix that contains the most nonzero entries. This problem is a natural generalization of fundamental problems in combinatorial optimization, e.g., the densest subgraph, maximum clique, and maximum edge biclique problems, and has wide application the study of complex networks. Much recent research has focused on the development of sufficient conditions for exact solution of the densest submatrix problem via convex relaxation. The vast majority of these sufficient conditions establish identification of the densest submatrix within a graph containing exactly one large dense submatrix hidden by noise. The assumptions of these underlying models are not observed in real-world networks, where the data may correspond to a matrix containing many dense submatrices of varying sizes. We extend and generalize these results to the more realistic setting where the input matrix may contain \emph{many} large dense subgraphs. Specifically, we establish sufficient conditions under which we can expect to solve the densest submatrix problem in polynomial time for random input matrices sampled from a generalization of the stochastic block model. Moreover, we also provide sufficient conditions for perfect recovery under a deterministic adversarial. Numerical experiments involving randomly generated problem instances and real-world collaboration and communication networks are used empirically to verify the theoretical phase-transitions to perfect recovery given by these sufficient conditions.

We consider operator learning for efficiently solving parametric non-self-adjoint eigenvalue problems. To overcome the spectral instability and mode switching associated with non-self-adjoint operators, we choose to learn the eigenspace rather than individual eigenfunctions. In particular, we propose a Deep Eigenspace Network (DEN) architecture integrating Fourier Neural Operators, geometry-adaptive POD bases, and explicit banded cross-mode mixing mechanism to capture complex spectral dependencies. We apply DEN to the non-self-adjoint Steklov eigenvalue problem and prove the Lipschitz continuity of the eigenspace with respect to the parameter. Furthermore, we derive error bounds for the eigenvalues. Numerical experiments validate that DEN is highly effective and efficient.

Large Language Models (LLMs) are often fine-tuned to adapt their general-purpose knowledge to specific tasks and domains such as cyber threat intelligence (CTI). Fine-tuning is mostly done through proprietary datasets that may contain sensitive information. Owners expect their fine-tuned model to not inadvertently leak this information to potentially adversarial end users. Using CTI as a use case, we demonstrate that data-extraction attacks can recover sensitive information from fine-tuned models on CTI reports, underscoring the need for mitigation. Retraining the full model to eliminate this leakage is computationally expensive and impractical. We propose an alternative approach, which we call privacy alignment, inspired by safety alignment in LLMs. Just like safety alignment teaches the model to abide by safety constraints through a few examples, we enforce privacy alignment through few-shot supervision, integrating a privacy classifier and a privacy redactor, both handled by the same underlying LLM. We evaluate our system, called CTIGuardian, using GPT-4o mini and Mistral-7B Instruct models, benchmarking against Presidio, a named entity recognition (NER) baseline. Results show that CTIGuardian provides a better privacy-utility trade-off than NER based models. While we demonstrate its effectiveness on a CTI use case, the framework is generic enough to be applicable to other sensitive domains.

Spectral super-resolution (SSR) aims to reconstruct hyperspectral images (HSIs) from multispectral observations, with broad applications in computer vision and remote sensing. Deep learning-based methods have been widely used, but they often treat spectra as discrete vectors learned from data, rather than continuous curves constrained by physics principles, leading to unrealistic predictions and limited applicability. To address this challenge, we propose the Radiative-Structured Neural Operator (RSNO), which learns a continuous mapping for spectral super-resolution while enforcing physical consistency under the radiative prior. The proposed RSNO consists of three stages: upsampling, reconstruction, and refinement. In the upsampling stage, we leverage prior information to expand the input multispectral image, producing a physically plausible hyperspectral estimate. Subsequently, we adopt a neural operator backbone in the reconstruction stage to learn a continuous mapping across the spectral domain. Finally, the refinement stage imposes a hard constraint on the output HSI to eliminate color distortion. The upsampling and refinement stages are implemented via the proposed angular-consistent projection (ACP), which is derived from a non-convex optimization problem. Moreover, we theoretically demonstrated the optimality of ACP by null-space decomposition. Various experiments validate the effectiveness of the proposed approach in both discrete and continuous spectral super-resolution.

Emerging continual learning applications necessitate next-generation neural processing unit (NPU) platforms to support both training and inference operations. The promising Microscaling (MX) standard enables narrow bit-widths for inference and large dynamic ranges for training. However, existing MX multiply-accumulate (MAC) designs face a critical trade-off: integer accumulation requires expensive conversions from narrow floating-point products, while FP32 accumulation suffers from quantization losses and costly normalization. To address these limitations, we propose a hybrid precision-scalable reduction tree for MX MACs that combines the benefits of both approaches, enabling efficient mixed-precision accumulation with controlled accuracy relaxation. Moreover, we integrate an 8x8 array of these MACs into the state-of-the-art (SotA) NPU integration platform, SNAX, to provide efficient control and data transfer to our optimized precision-scalable MX datapath. We evaluate our design both on MAC and system level and compare it to the SotA. Our integrated system achieves an energy efficiency of 657, 1438-1675, and 4065 GOPS/W, respectively, for MXINT8, MXFP8/6, and MXFP4, with a throughput of 64, 256, and 512 GOPS.

We initiate an investigation of learning tasks in a setting where the learner is given access to two competing provers, only one of which is honest. Specifically, we consider the power of such learners in assessing purported properties of opaque models. Following prior work in complexity theory that considers the power of competing provers in various settings, we call this setting refereed learning. After formulating a general definition of refereed learning tasks, we show refereed learning protocols that obtain a level of accuracy that far exceeds what is obtainable at comparable cost without provers, or even with a single prover. We concentrate on the task of choosing the better one out of two black-box models, with respect to some ground truth. While we consider a range of parameters, perhaps our most notable result is in the high-precision range: For all $\varepsilon>0$ and ambient dimension $d$, our learner makes only one query to the ground truth function, communicates only $(1+\frac{1}{\varepsilon^2})\cdot\text{poly}(d)$ bits with the provers, and outputs a model whose loss is within a multiplicative factor of $(1+\varepsilon)$ of the best model's loss. Obtaining comparable loss with a single prover would require the learner to access the ground truth at almost all of the points in the domain. We also present lower bounds that demonstrate the optimality of our protocols in a number of respects, including prover complexity, number of samples, and need for query access.

Collaborative group projects are integral to computer science education, fostering teamwork, problem-solving, and industry-relevant skills. However, assessing individual contributions within group settings remains challenging. Traditional approaches, including equal grade distribution and subjective peer evaluations, often lack fairness, objectivity, and scalability, particularly in large classrooms. We propose TRACE, a semi-automated AI-assisted framework for assessing collaborative software projects that evaluates both project quality and individual contributions using repository mining, communication analytics, and AI-assisted analytics. A pilot deployment in a software engineering course demonstrated high alignment with instructor assessments, increased student satisfaction, and reduced instructor grading effort. The results suggest that AI-assisted analytics can improve the transparency and scalability of collaborative project assessment in computer science education.

Flow Matching, a promising approach in generative modeling, has recently gained popularity. Relying on ordinary differential equations, it offers a simple and flexible alternative to diffusion models, which are currently the state-of-the-art. Despite its empirical success, the mathematical understanding of its statistical power so far is very limited. This is largely due to the sensitivity of theoretical bounds to the Lipschitz constant of the vector field which drives the ODE. In this work, we study the assumptions that lead to controlling this dependency. Based on these results, we derive a convergence rate for the Wasserstein $1$ distance between the estimated distribution and the target distribution which improves previous results in high dimensional setting. This rate applies to certain classes of unbounded distributions and particularly does not require $\log$-concavity.

The restricted Boltzmann machine (RBM) is a neural network based on the Ising model, well known for its ability to learn probability distributions and stochastically generate new content. However, the high computational cost of Gibbs sampling in content generation tasks imposes significant bottlenecks on electronic implementations. Here, we propose a photonic restricted Boltzmann machine (PRBM) that leverages photonic computing to accelerate Gibbs sampling, enabling efficient content generation. By introducing an efficient encoding method, the PRBM eliminates the need for computationally intensive matrix decomposition and reduces the computational complexity of Gibbs sampling from $O(N)$ to $O(1)$. Moreover, its non-Von Neumann photonic computing architecture circumvents the memory storage of interaction matrices, providing substantial advantages for large-scale RBMs. We experimentally validate the photonic-accelerated Gibbs sampling by simulating a two-dimensional Ising model, where the observed phase transition temperature closely matches the theoretical predictions. Beyond physics-inspired tasks, the PRBM demonstrates robust capabilities in generating and restoring diverse content, including images and temporal sequences, even in the presence of noise and aberrations. The scalability and reduced training cost of the PRBM framework underscore its potential as a promising pathway for advancing photonic computing in generative artificial intelligence.

Smart agriculture applications, integrating technologies like the Internet of Things and machine learning/artificial intelligence (ML/AI) into agriculture, hold promise to address modern challenges of rising food demand, environmental pollution, and water scarcity. Alongside the concept of the phytobiome, which defines the area including the plant, its environment, and associated organisms, and the recent emergence of molecular communication (MC), there exists an important opportunity to advance agricultural science and practice using communication theory. In this article, we motivate to use the communication engineering perspective for developing a holistic understanding of the phytobiome communication and bridge the gap between the phytobiome communication and smart agriculture. Firstly, an overview of phytobiome communication via molecular and electrophysiological signals is presented and a multi-scale framework modeling the phytobiome as a communication network is conceptualized. Then, how this framework is used to model electrophysiological signals is demonstrated with plant experiments. Furthermore, possible smart agriculture applications, such as smart irrigation and targeted delivery of agrochemicals, through engineering the phytobiome communication are proposed. These applications merge ML/AI methods with the Internet of Bio-Nano-Things enabled by MC and pave the way towards more efficient, sustainable, and eco-friendly agricultural production. Finally, the implementation challenges, open research issues, and industrial outlook for these applications are discussed.

Advancing large language models (LLMs) for the next point-of-interest (POI) recommendation task faces two fundamental challenges: (i) although existing methods produce semantic IDs that incorporate semantic information, their topology-blind indexing fails to preserve semantic continuity, meaning that proximity in ID values does not mirror the coherence of the underlying semantics; and (ii) supervised fine-tuning (SFT)-based methods restrict model outputs to top-1 predictions. These approaches suffer from "answer fixation" and neglect the need for top-k ranked lists and reasoning due to the scarcity of supervision. We propose Refine-POI, a framework that addresses these challenges through topology-aware ID generation and reinforcement fine-tuning. First, we introduce a hierarchical self-organizing map (SOM) quantization strategy to generate semantic IDs, ensuring that coordinate proximity in the codebook reflects semantic similarity in the latent space. Second, we employ a policy-gradient framework to optimize the generation of top-k recommendation lists, liberating the model from strict label matching. Extensive experiments on three real-world datasets demonstrate that Refine-POI significantly outperforms state-of-the-art baselines, effectively synthesizing the reasoning capabilities of LLMs with the representational fidelity required for accurate and explainable next-POI recommendation.

3D Gaussian Splatting (3DGS) achieves an appealing balance between rendering quality and efficiency, but relies on approximating 3D Gaussians as 2D projections--an assumption that degrades accuracy, especially under generic large field-of-view (FoV) cameras. Despite recent extensions, no prior work has simultaneously achieved both projective exactness and real-time efficiency for general cameras. We introduce 3DGEER, a geometrically exact and efficient Gaussian rendering framework. From first principles, we derive a closed-form expression for integrating Gaussian density along a ray, enabling precise forward rendering and differentiable optimization under arbitrary camera models. To retain efficiency, we propose the Particle Bounding Frustum (PBF), which provides tight ray-Gaussian association without BVH traversal, and the Bipolar Equiangular Projection (BEAP), which unifies FoV representations, accelerates association, and improves reconstruction quality. Experiments on both pinhole and fisheye datasets show that 3DGEER outperforms prior methods across all metrics, runs 5x faster than existing projective exact ray-based baselines, and generalizes to wider FoVs unseen during training--establishing a new state of the art in real-time radiance field rendering.

A key claim in recent work on Selective State Space Models is that selectivity, the ability to focus on relevant information while filtering irrelevant inputs, requires breaking the Linear Time-Invariant (LTI) property through time-varying dynamics. We challenge this claim by demonstrating that LTI systems can achieve selectivity when designed using principles from geometric control. We introduce the Geometric SSM, in which different input patterns excite distinct invariant subspaces of the dynamics. Unlike Mamba's memoryless selection mechanism, our approach employs a dynamic residual generator that maintains temporal memory, enabling recognition of multi-token patterns without time-varying system matrices. The Geometric SSM achieves near-perfect performance on a novel extended induction head task where Mamba fails, while preserving efficient FFT-based training. Our results demonstrate that geometric control theory can inform the design of novel selective sequence models that combine theoretical rigor with practical efficiency.

Jailbreak attacks pose a serious threat to Large Language Models (LLMs) by bypassing their safety mechanisms. A truly advanced jailbreak is defined not only by its effectiveness but, more critically, by its stealthiness. However, existing methods face a fundamental trade-off between semantic stealth (hiding malicious intent) and linguistic stealth (appearing natural), leaving them vulnerable to detection. To resolve this trade-off, we propose StegoAttack, a framework that leverages steganography. The core insight is to embed a harmful query within a benign, semantically coherent paragraph. This design provides semantic stealth by concealing the existence of malicious content and ensures linguistic stealth by maintaining the natural fluency of the cover paragraph. We evaluate StegoAttack on four state-of-the-art, safety-aligned LLMs, including GPT-5 and Gemini-3, and benchmark it against eight leading jailbreak methods. Our results show that StegoAttack achieves an average attack success rate (ASR) of 95.50%, outperforming existing baselines across all four models. Critically, its ASR drops by less than 27.00% under external detectors, while maintaining natural language distribution. This demonstrates that steganography effectively decouples linguistic and semantic stealth, thereby posing a fully concealed yet highly effective security threat. The code is available at https://github.com/GenggengSvan/StegoAttack

Recent advances in recommendation with large language models (LLMs) often rely on either commonsense augmentation at the item-category level or implicit intent modeling on existing knowledge graphs. However, such approaches struggle to capture grounded user intents and to handle sparsity and cold-start scenarios. In this work, we present LLM-based Intent Knowledge Graph Recommender (IKGR), a novel framework that constructs an intent-centric knowledge graph where both users and items are explicitly linked to intent nodes extracted by a tuning-free, RAG-guided LLM pipeline. By grounding intents in external knowledge sources and user profiles, IKGR canonically represents what a user seeks and what an item satisfies as first-class entities. To alleviate sparsity, we further introduce a mutual-intent connectivity densification strategy, which shortens semantic paths between users and long-tail items without requiring cross-graph fusion. Finally, a lightweight GNN layer is employed on top of the intent-enhanced graph to produce recommendation signals with low latency. Extensive experiments on public and enterprise datasets demonstrate that IKGR consistently outperforms strong baselines, particularly on cold-start and long-tail slices, while remaining efficient through a fully offline LLM pipeline.

Climate change is a major threat to the future of humanity, and its impacts are being intensified by excess man-made greenhouse gas emissions. One method governments can employ to control these emissions is to provide firms with emission limits and penalize any excess emissions above the limit. Excess emissions may also be offset by firms who choose to invest in carbon reducing and capturing projects. These projects generate offset credits which can be submitted to a regulating agency to offset a firm's excess emissions, or they can be traded with other firms. In this work, we characterize the finite-agent Nash equilibrium for offset credit markets. As computing Nash equilibria is an NP-hard problem, we utilize the modern reinforcement learning technique Nash-DQN to efficiently estimate the market's Nash equilibria. We demonstrate not only the validity of employing reinforcement learning methods applied to climate themed financial markets, but also the significant financial savings emitting firms may achieve when abiding by the Nash equilibria through numerical experiments.

Multimodal large language models (MLLMs), such as GPT-4o, are garnering significant attention. During the exploration of MLLM training, we identified Modality Composition Incoherence, a phenomenon that the proportion of a certain modality varies dramatically across different examples. It exacerbates the challenges of addressing mini-batch imbalances, which lead to uneven GPU utilization between Data Parallel (DP) instances and severely degrades the efficiency and scalability of MLLM training, ultimately affecting training speed and hindering further research on MLLMs. To address these challenges, we introduce OrchMLLM, a comprehensive framework designed to mitigate the inefficiencies in MLLM training caused by Modality Composition Incoherence. First, we propose Batch Post-Balancing Dispatcher, a technique that efficiently eliminates mini-batch imbalances in sequential data. Additionally, we integrate MLLM Global Orchestrator into the training framework to orchestrate multimodal data and tackle the issues arising from Modality Composition Incoherence. We evaluate OrchMLLM across various MLLM sizes, demonstrating its efficiency and scalability. Experimental results reveal that OrchMLLM achieves a Model FLOPs Utilization (MFU) of $41.6\%$ when training an 84B MLLM with three modalities on $2560$ H100 GPUs, outperforming Megatron-LM by up to $3.1\times$ in throughput.

Large Language Models (LLMs) have demonstrated impressive ability in generation and reasoning tasks but struggle with handling up-to-date knowledge, leading to inaccuracies or hallucinations. Retrieval-Augmented Generation (RAG) mitigates this by retrieving and incorporating external knowledge into input prompts. In particular, due to LLMs' context window limitations and long-context hallucinations, only the most relevant "chunks" are retrieved. However, current RAG systems face three key challenges: (1) chunks are often retrieved independently without considering their relationships, such as redundancy and ordering; (2) the utility of chunks is non-monotonic, as adding more chunks can degrade quality; and (3) retrieval strategies fail to adapt to the unique characteristics of different queries. To overcome these challenges, we design a cost-constrained retrieval optimization framework for RAG. We adopt a Monte Carlo Tree Search (MCTS) based strategy to find the optimal chunk combination order, which considers the chunks' correlations. In addition, to address the non-monotonicity of chunk utility, instead of treating budget exhaustion as the termination condition, we design a utility computation strategy to identify the optimal chunk combination without necessarily exhausting the budget. Furthermore, we propose a configuration agent that predicts optimal configurations for each query domain, improving our framework's adaptability and efficiency. Experimental results demonstrate up to a 30% improvement over baseline models, highlighting the framework's effectiveness, scalability, and suitability. Our source code has been released at https://github.com/wang0702/CARROT.

Multi-agent Reinforcement Learning (MARL) is emerging as a key framework for various sequential decision-making and control tasks. Unlike their single-agent counterparts, multi-agent systems necessitate successful cooperation among the agents. The deployment of these systems in real-world scenarios often requires decentralized training, a diverse set of agents, and learning from infrequent environmental reward signals. These challenges become more pronounced under partial observability and the lack of prior knowledge about agent heterogeneity. While notable studies use intrinsic motivation (IM) to address reward sparsity or cooperation in decentralized settings, those dealing with heterogeneity typically assume centralized training, parameter sharing, and agent indexing. To overcome these limitations, we propose the CoHet algorithm, which utilizes a novel Graph Neural Network (GNN) based intrinsic motivation to facilitate the learning of heterogeneous agent policies in decentralized settings, under the challenges of partial observability and reward sparsity. Evaluation of CoHet in the Multi-agent Particle Environment (MPE) and Vectorized Multi-Agent Simulator (VMAS) benchmarks demonstrates superior performance compared to the state-of-the-art in a range of cooperative multi-agent scenarios. Our research is supplemented by an analysis of the impact of the agent dynamics model on the intrinsic motivation module, insights into the performance of different CoHet variants, and its robustness to an increasing number of heterogeneous agents.

Predicting the outcome of antiretroviral therapies (ART) for HIV-1 is a pressing clinical challenge, especially when the ART includes drugs with limited effectiveness data. This scarcity of data can arise either due to the introduction of a new drug to the market or due to limited use in clinical settings, resulting in clinical dataset with highly unbalanced therapy representation. To tackle this issue, we introduce a novel joint fusion model, which combines features from a Fully Connected (FC) Neural Network and a Graph Neural Network (GNN) in a multi-modality fashion. Our model uses both tabular data about genetic sequences and a knowledge base derived from Stanford drug-resistance mutation tables, which serve as benchmark references for deducing in-vivo treatment efficacy based on the viral genetic sequence. By leveraging this knowledge base structured as a graph, the GNN component enables our model to adapt to imbalanced data distributions and account for Out-of-Distribution (OoD) drugs. We evaluated these models' robustness against OoD drugs in the test set. Our comprehensive analysis demonstrates that the proposed model consistently outperforms the FC model. These results underscore the advantage of integrating Stanford scores in the model, thereby enhancing its generalizability and robustness, but also extending its utility in contributing in more informed clinical decisions with limited data availability. The source code is available at https://github.com/federicosiciliano/graph-ood-hiv

Contrast Enhanced Spectral Mammography (CESM) is a dual-energy mammographic imaging technique that first needs intravenously administration of an iodinated contrast medium; then, it collects both a low-energy image, comparable to standard mammography, and a high-energy image. The two scans are then combined to get a recombined image showing contrast enhancement. Despite CESM diagnostic advantages for breast cancer diagnosis, the use of contrast medium can cause side effects, and CESM also beams patients with a higher radiation dose compared to standard mammography. To address these limitations this work proposes to use deep generative models for virtual contrast enhancement on CESM, aiming to make the CESM contrast-free as well as to reduce the radiation dose. Our deep networks, consisting of an autoencoder and two Generative Adversarial Networks, the Pix2Pix, and the CycleGAN, generate synthetic recombined images solely from low-energy images. We perform an extensive quantitative and qualitative analysis of the model's performance, also exploiting radiologists' assessments, on a novel CESM dataset that includes 1138 images that, as a further contribution of this work, we make publicly available. The results show that CycleGAN is the most promising deep network to generate synthetic recombined images, highlighting the potential of artificial intelligence techniques for virtual contrast enhancement in this field.

The COVID-19 pandemic has caused millions of cases and deaths and the AI-related scientific community, after being involved with detecting COVID-19 signs in medical images, has been now directing the efforts towards the development of methods that can predict the progression of the disease. This task is multimodal by its very nature and, recently, baseline results achieved on the publicly available AIforCOVID dataset have shown that chest X-ray scans and clinical information are useful to identify patients at risk of severe outcomes. While deep learning has shown superior performance in several medical fields, in most of the cases it considers unimodal data only. In this respect, when, which and how to fuse the different modalities is an open challenge in multimodal deep learning. To cope with these three questions here we present a novel approach optimizing the setup of a multimodal end-to-end model. It exploits Pareto multi-objective optimization working with a performance metric and the diversity score of multiple candidate unimodal neural networks to be fused. We test our method on the AIforCOVID dataset, attaining state-of-the-art results, not only outperforming the baseline performance but also being robust to external validation. Moreover, exploiting XAI algorithms we figure out a hierarchy among the modalities and we extract the features' intra-modality importance, enriching the trust on the predictions made by the model.

Transport measurements on thin films of the prototypical altermagnet MnTe have reported conflicting phenomena of anomalous Hall effects (AHE), including opposite signs and thickness-independent resistivity. Here we resolve these discrepancies by separating bulk and surface contributions to the AHE for different crystal terminations. Using first-principles calculations and symmetry-based effective models, we show that although the bulk hosts a characteristic $g$-wave Fermi surface, surface states within the bulk gap acquire a ferromagnet-like spin polarization and dominate the AHE at experimentally relevant Fermi energies. While the surface magnetization follows the surface spin sublattice, the resulting AHE is uniquely determined by the bulk Néel order for a given termination. Both bulk and surface contributions are closely linked to a small but finite out-of-plane orbital magnetization. Incorporating realistic interfacial chemistry further reveals that a Te capping layer can reverse the surface AHE sign relative to that on an InP substrate. Our results establish a microscopic framework for interpreting and engineering AHE responses in altermagnetic thin films through interface design.