The rise of Antimicrobial Resistance, particularly Multi-Drug Resistance (MDR), presents a critical challenge for clinical decision-making due to limited treatment options and delays in conventional susceptibility testing. This study proposes an interpretable machine learning framework to predict MDR in bacterial isolates using clinical features and antibiotic susceptibility patterns. Five classification models were evaluated, including Logistic Regression, Random Forest, AdaBoost, XGBoost, and LightGBM. The models were trained on a curated dataset of 9,714 isolates, with resistance encoded at the antibiotic family level to capture cross-class resistance patterns consistent with MDR definitions. Performance assessment included accuracy, F1-score, AUC-ROC, and Matthews Correlation Coefficient. Ensemble models, particularly XGBoost and LightGBM, demonstrated superior predictive capability across all metrics. To address the clinical transparency gap, Local Interpretable Model-agnostic Explanations (LIME) was applied to generate instance-level explanations. LIME identified resistance to quinolones, Co-trimoxazole, Colistin, aminoglycosides, and Furanes as the strongest contributors to MDR predictions, aligning with known biological mechanisms. The results show that combining high-performing models with local interpretability provides both accuracy and actionable insights for antimicrobial stewardship. This framework supports earlier MDR identification and enhances trust in machine learning-assisted clinical decision support.

Lossless compression is essential for efficient data storage and transmission. Although learning-based lossless compressors achieve strong results, most of them are designed for a single modality, leading to redundant compressor deployments in multi-modal settings. Designing a unified multi-modal compressor is critical yet challenging, as different data types vary largely in format, dimension, and statistics. Multi-modal large language models offer a promising resolution but remain too complex for practical use. Thus, we propose \textbf{OmniZip}, \textbf{a unified and lightweight lossless compressor for multi-modal data (like image, text, speech, tactile, database, and gene sequence)}. Built on a lightweight backbone, OmniZip incorporates three key components to enable efficient multi-modal lossless compression: a modality-unified tokenizer that reversibly transforms diverse data into tokens, a modality-routing context learning mechanism that enables flexible multi-modal context modeling, and a modality-routing feedforward design that further enhances the model's nonlinear representation flexibility. A reparameterization training strategy is used to enhance model capacity. OmniZip outperforms or matches other state-of-the-art compressors on multiple modalities, achieving 42\%, 57\%, 62\% and 42\%, 53\% higher compression efficiency than gzip on CLIC-M, TouchandGo, enwik9, LibriSpeech, and WikiSQL datasets, respectively. It also supports near real-time inference on resource-constrained edge devices, reaching about 1MB/s on MacBook CPUs and iPhone NPUs. Our code is released at https://github.com/adminasmi/OmniZip-CVPR2026.

Recent advancements in deep learning have actively addressed complex challenges within the Computer-Aided Design (CAD) domain.However, most existing approaches rely on task-specifi c models requiring structural modifi cations for new tasks, and they predominantly focus on point clouds or images rather than the industry-standard Boundary Representation (B-rep) format. To address these limitations, we propose BrepCoder, a unifi ed Multimodal Large Language Model (MLLM) that performs diverse CAD tasks from B-rep inputs. By leveraging the code generation capabilities of Large Language Models (LLMs), we convert CAD modeling sequences into Python-like code and align them with B-rep. We then adopt a two-stage training strategy: First, pre-training on reverse engineering to learn geometric features and design logic. Second, eff ectively extending the model to various downstream tasks such as completion, error correction, and CAD-QA. Consequently, by interpreting B-rep as structural code, BrepCoder achieves superior generalization across diverse tasks, demonstrating its potential as a general-purpose CAD agent.

We propose Light-Geometry Interaction (LGI) maps, a novel representation that encodes light-aware occlusion from monocular depth. Unlike ray tracing, which requires full 3D reconstruction, LGI captures essential light-shadow interactions reliably and accurately, computed from off-the-shelf 2.5D depth map predictions. LGI explicitly ties illumination direction to geometry, providing a physics-inspired prior that constrains generative models. Without such prior, these models often produce floating shadows, inconsistent illumination, and implausible shadow geometry. Building on this representation, we propose a unified pipeline for joint shadow generation and relighting - unlike prior methods that treat them as disjoint tasks - capturing the intrinsic coupling of illumination and shadowing essential for modeling indirect effects. By embedding LGI into a bridge-matching generative backbone, we reduce ambiguity and enforce physically consistent light-shadow reasoning. To enable effective training, we curated the first large-scale benchmark dataset for joint shadow and relighting, covering reflections, transparency, and complex interreflections. Experiments show significant gains in realism and consistency across synthetic and real images. LGI thus bridges geometry-inspired rendering with generative modeling, enabling efficient, physically consistent shadow generation and relighting.

Cascaded speech-to-text translation (S2TT) systems for low-resource languages can suffer from structural noise, particularly the loss of punctuation during the Automatic Speech Recognition (ASR) phase. This research investigates the impact of such noise on Nepali-to-English translation and proposes an optimized pipeline to mitigate quality degradation. We first establish highly proficient ASR and NMT components: a Wav2Vec2-XLS-R-300m model achieved a state-of-the-art 2.72% CER on OpenSLR-54, and a multi-stage fine-tuned MarianMT model reached a 28.32 BLEU score on the FLORES-200 benchmark. We empirically investigate the influence of punctuation loss, demonstrating that unpunctuated ASR output significantly degrades translation quality, causing a massive 20.7% relative BLEU drop on the FLORES benchmark. To overcome this, we propose and evaluate an intermediate Punctuation Restoration Module (PRM). The final S2TT pipeline was tested across three configurations on a custom dataset. The optimal configuration, which applied the PRM directly to ASR output, achieved a 4.90 BLEU point gain over the direct ASR-to-NMT baseline (BLEU 36.38 vs. 31.48). This improvement was validated by human assessment, which confirmed the optimized pipeline's superior Adequacy (3.673) and Fluency (3.804) with inter-rater reliability (Krippendorff's $α {\geq}$ 0.723). This work validates that targeted punctuation restoration is the most effective intervention for mitigating structural noise in the Nepali S2TT pipeline. It establishes an optimized baseline and demonstrates a critical architectural insight for developing cascaded speech translation systems for similar low-resource languages.

Image-to-Video (I2V) generation models, which condition video generation on reference images, have shown emerging visual instruction-following capability, allowing certain visual cues in reference images to act as implicit control signals for video generation. However, this capability also introduces a previously overlooked risk: adversaries may exploit visual instructions to inject malicious intent through the image modality. In this work, we uncover this risk by proposing Visual Instruction Injection (VII), a training-free and transferable jailbreaking framework that intentionally disguises the malicious intent of unsafe text prompts as benign visual instructions in the safe reference image. Specifically, VII coordinates a Malicious Intent Reprogramming module to distill malicious intent from unsafe text prompts while minimizing their static harmfulness, and a Visual Instruction Grounding module to ground the distilled intent onto a safe input image by rendering visual instructions that preserve semantic consistency with the original unsafe text prompt, thereby inducing harmful content during I2V generation. Empirically, our extensive experiments on four state-of-the-art commercial I2V models (Kling-v2.5-turbo, Gemini Veo-3.1, Seedance-1.5-pro, and PixVerse-V5) demonstrate that VII achieves Attack Success Rates of up to 83.5% while reducing Refusal Rates to near zero, significantly outperforming existing baselines.

Urban systems, as dynamic complex systems, continuously generate spatio-temporal data streams that encode the fundamental laws of human mobility and city evolution. While AI for Science has witnessed the transformative power of foundation models in disciplines like genomics and meteorology, urban computing remains fragmented due to "scenario-specific" models, which are overfitted to specific regions or tasks, hindering their generalizability. To bridge this gap and advance spatio-temporal foundation models for urban systems, we adopt scaling as the central perspective and systematically investigate two key questions: what to scale and how to scale. Grounded in first-principles analysis, we identify three critical dimensions: heterogeneity, correlation, and dynamics, aligning these principles with the fundamental scientific properties of urban spatio-temporal data. Specifically, to address heterogeneity through data scaling, we construct WorldST. This billion-scale corpus standardizes diverse physical signals, such as traffic flow and speed, from over 100 global cities into a unified data format. To enable computation scaling for modeling correlations, we introduce the MiniST unit, a novel split mechanism that discretizes continuous spatio-temporal fields into learnable computational units to unify representations of grid-based and sensor-based observations. Finally, addressing dynamics via architecture scaling, we propose UrbanFM, a minimalist self-attention architecture designed with limited inductive biases to autonomously learn dynamic spatio-temporal dependencies from massive data. Furthermore, we establish EvalST, the largest-scale urban spatio-temporal benchmark to date. Extensive experiments demonstrate that UrbanFM achieves remarkable zero-shot generalization across unseen cities and tasks, marking a pivotal first step toward large-scale urban spatio-temporal foundation models.

Large-scale image datasets are fundamental to deep learning, but their high storage demands pose challenges for deployment in resource-constrained environments. While existing approaches reduce dataset size by discarding samples, they often ignore the significant redundancy within each image -- particularly in the color space. To address this, we propose Dataset Color Quantization (DCQ), a unified framework that compresses visual datasets by reducing color-space redundancy while preserving information crucial for model training. DCQ achieves this by enforcing consistent palette representations across similar images, selectively retaining semantically important colors guided by model perception, and maintaining structural details necessary for effective feature learning. Extensive experiments across CIFAR-10, CIFAR-100, Tiny-ImageNet, and ImageNet-1K show that DCQ significantly improves training performance under aggressive compression, offering a scalable and robust solution for dataset-level storage reduction.

As Large Language Models (LLMs) saturate elementary benchmarks, the research frontier has shifted from generation to the reliability of automated evaluation. We demonstrate that standard "LLM-as-a-Judge" protocols suffer from a systematic Alignment Gap when applied to upper-undergraduate to early graduate level mathematics. To quantify this, we introduce QEDBench, the first large-scale dual-rubric alignment benchmark to systematically measure alignment with human experts on university-level math proofs by contrasting course-specific rubrics against expert common knowledge criteria. By deploying a dual-evaluation matrix (7 judges x 5 solvers) against 1,000+ hours of human evaluation, we reveal that certain frontier evaluators like Claude Opus 4.5, DeepSeek-V3, Qwen 2.5 Max, and Llama 4 Maverick exhibit significant positive bias (up to +0.18, +0.20, +0.30, +0.36 mean score inflation, respectively). Furthermore, we uncover a critical reasoning gap in the discrete domain: while Gemini 3.0 Pro achieves state-of-the-art performance (0.91 average human evaluation score), other reasoning models like GPT-5 Pro and Claude Sonnet 4.5 see their performance significantly degrade in discrete domains. Specifically, their average human evaluation scores drop to 0.72 and 0.63 in Discrete Math, and to 0.74 and 0.50 in Graph Theory. In addition to these research results, we also release QEDBench as a public benchmark for evaluating and improving AI judges. Our benchmark is publicly published at https://github.com/qqliu/Yale-QEDBench.

Edge-based representations are fundamental cues for visual understanding, a principle rooted in early vision research and still central today. We extend this principle to vision-language alignment, showing that isolating and aligning structural cues across modalities can greatly benefit fine-tuning on long, detail-rich captions, with a specific focus on improving cross-modal retrieval. We introduce StructXLIP, a fine-tuning alignment paradigm that extracts edge maps (e.g., Canny), treating them as proxies for the visual structure of an image, and filters the corresponding captions to emphasize structural cues, making them "structure-centric". Fine-tuning augments the standard alignment loss with three structure-centric losses: (i) aligning edge maps with structural text, (ii) matching local edge regions to textual chunks, and (iii) connecting edge maps to color images to prevent representation drift. From a theoretical standpoint, while standard CLIP maximizes the mutual information between visual and textual embeddings, StructXLIP additionally maximizes the mutual information between multimodal structural representations. This auxiliary optimization is intrinsically harder, guiding the model toward more robust and semantically stable minima, enhancing vision-language alignment. Beyond outperforming current competitors on cross-modal retrieval in both general and specialized domains, our method serves as a general boosting recipe that can be integrated into future approaches in a plug-and-play manner. Code and pretrained models are publicly available at: https://github.com/intelligolabs/StructXLIP.

Long-context modeling is essential for symbolic music generation, since motif repetition and developmental variation can span thousands of musical events, yet practical workflows frequently rely on resource-limited hardware. We introduce Depth-Structured Music Recurrence (DSMR), a training-time design that learns from complete compositions end to end by streaming each piece left-to-right with stateful recurrent attention and distributing layer-wise memory horizons under a fixed recurrent-state budget. Our main instantiation, two-scale DSMR, assigns long history windows to lower layers and a uniform short window to the remaining layers. On the MAESTRO piano performance dataset, two-scale DSMR matches a full-memory recurrent reference in perplexity (5.96 vs. 5.98) while using approximately 59% less GPU memory and achieving roughly 36% higher throughput. Variant analyses further show strong layer substitutability under binary-horizon schedules: performance depends primarily on total allocated memory rather than which layers carry it.

Temporal information in structured electronic health records (EHRs) is often lost in sparse one-hot or count-based representations, while sequence models can be costly and data-hungry. We propose PaReGTA, an LLM-based encoding framework that (i) converts longitudinal EHR events into visit-level templated text with explicit temporal cues, (ii) learns domain-adapted visit embeddings via lightweight contrastive fine-tuning of a sentence-embedding model, and (iii) aggregates visit embeddings into a fixed-dimensional patient representation using hybrid temporal pooling that captures both recency and globally informative visits. Because PaReGTA does not require training from scratch but instead utilizes a pre-trained LLM, it can perform well even in data-limited cohorts. Furthermore, PaReGTA is model-agnostic and can benefit from future EHR-specialized sentence-embedding models. For interpretability, we introduce PaReGTA-RSS (Representation Shift Score), which quantifies clinically defined factor importance by recomputing representations after targeted factor removal and projecting representation shifts through a machine learning model. On 39,088 migraine patients from the All of Us Research Program, PaReGTA outperforms sparse baselines for migraine type classification while deep sequential models were unstable in our cohort.

Hepatocellular Carcinoma diagnosis relies heavily on the interpretation of gigapixel Whole Slide Images. However, current computational approaches are constrained by fixed-resolution processing mechanisms and inefficient feature aggregation, which inevitably lead to either severe information loss or high feature redundancy. To address these challenges, we propose Hepato-LLaVA, a specialized Multi-modal Large Language Model designed for fine-grained hepatocellular pathology analysis. We introduce a novel Sparse Topo-Pack Attention mechanism that explicitly models 2D tissue topology. This mechanism effectively aggregates local diagnostic evidence into semantic summary tokens while preserving global context. Furthermore, to overcome the lack of multi-scale data, we present HepatoPathoVQA, a clinically grounded dataset comprising 33K hierarchically structured question-answer pairs validated by expert pathologists. Our experiments demonstrate that Hepato-LLaVA achieves state-of-the-art performance on HCC diagnosis and captioning tasks, significantly outperforming existing methods. Our code and implementation details are available at https://pris-cv.github.io/Hepto-LLaVA/.

Spatio-temporal forecasting is fundamental to intelligent systems in transportation, climate science, and urban planning. However, training deep learning models on the massive, often redundant, datasets from these domains presents a significant computational bottleneck. Existing solutions typically focus on optimizing model architectures or optimizers, while overlooking the inherent inefficiency of the training data itself. This conventional approach of iterating over the entire static dataset each epoch wastes considerable resources on easy-to-learn or repetitive samples. In this paper, we explore a novel training-efficiency techniques, namely learning from complexity with dynamic sample pruning, ST-Prune, for spatio-temporal forecasting. Through dynamic sample pruning, we aim to intelligently identify the most informative samples based on the model's real-time learning state, thereby accelerating convergence and improving training efficiency. Extensive experiments conducted on real-world spatio-temporal datasets show that ST-Prune significantly accelerates the training speed while maintaining or even improving the model performance, and it also has scalability and universality.

AI evaluation has primarily focused on measuring capabilities, with formal approaches inspired from Item Response Theory (IRT) being increasingly applied. Yet propensities - the tendencies of models to exhibit particular behaviours - play a central role in determining both performance and safety outcomes. However, traditional IRT describes a model's success on a task as a monotonic function of model capabilities and task demands, an approach unsuited to propensities, where both excess and deficiency can be problematic. Here, we introduce the first formal framework for measuring AI propensities by using a bilogistic formulation for model success, which attributes high success probability when the model's propensity is within an "ideal band". Further, we estimate the limits of the ideal band using LLMs equipped with newly developed task-agnostic rubrics. Applying our framework to six families of LLM models whose propensities are incited in either direction, we find that we can measure how much the propensity is shifted and what effect this has on the tasks. Critically, propensities estimated using one benchmark successfully predict behaviour on held-out tasks. Moreover, we obtain stronger predictive power when combining propensities and capabilities than either separately. More broadly, our framework showcases how rigorous propensity measurements can be conducted and how it yields gains over solely using capability evaluations to predict AI behaviour.

Large Language Models (LLMs) are increasingly used as automated annotators to scale dataset creation, yet their reliability as unbiased annotators--especially for low-resource and identity-sensitive settings--remains poorly understood. In this work, we study the behavior of LLMs as zero-shot annotators for Bangla hate speech, a task where even human agreement is challenging, and annotator bias can have serious downstream consequences. We conduct a systematic benchmark of 17 LLMs using a unified evaluation framework. Our analysis uncovers annotator bias and substantial instability in model judgments. Surprisingly, increased model scale does not guarantee improved annotation quality--smaller, more task-aligned models frequently exhibit more consistent behavior than their larger counterparts. These results highlight important limitations of current LLMs for sensitive annotation tasks in low-resource languages and underscore the need for careful evaluation before deployment.

We show that training AI agents on high-fidelity reinforcement learning environments produces capabilities that generalize beyond the training distribution. We introduce CoreCraft, the first environment in EnterpriseBench, Surge AI's suite of agentic RL environments. CoreCraft is a fully operational enterprise simulation of a customer support organization, comprising over 2,500 entities across 14 entity types with 23 unique tools, designed to measure whether AI agents can perform the multi-step, domain-specific work that real jobs demand. Frontier models such as GPT-5.2 and Claude Opus 4.6 solve fewer than 30% of tasks when all expert-authored rubric criteria must be satisfied. Using this environment, we train GLM 4.6 with Group Relative Policy Optimization (GRPO) and adaptive clipping. After a single epoch of training, the model improves from 25.37% to 36.76% task pass rate on held-out evaluation tasks. More importantly, these gains transfer to out-of-distribution benchmarks: +4.5% on BFCL Parallel, +7.4% on Tau2-Bench Retail, and +6.8% on Tool Decathlon (Pass@1). We believe three environment properties are consistent with the observed transfer: task-centric world building that optimizes for diverse, challenging tasks; expert-authored rubrics enabling reliable reward computation; and enterprise workflows that reflect realistic professional patterns. Our results suggest that environment quality, diversity, and realism are key factors enabling generalizable agent capabilities.

Computed Tomography (CT) is one of the most widely used and diagnostically information-dense imaging modalities, covering critical organs such as the heart, lungs, liver, and colon. Clinical interpretation relies on both slice-driven local features (e.g., sub-centimeter nodules, lesion boundaries) and volume-driven spatial representations (e.g., tumor infiltration, inter-organ anatomical relations). However, existing Large Vision-Language Models (LVLMs) remain fragmented in CT slice versus volumetric understanding: slice-driven LVLMs show strong generalization but lack cross-slice spatial consistency, while volume-driven LVLMs explicitly capture volumetric semantics but suffer from coarse granularity and poor compatibility with slice inputs. The absence of a unified modeling paradigm constitutes a major bottleneck for the clinical translation of medical LVLMs. We present OmniCT, a powerful unified slice-volume LVLM for CT scenarios, which makes three contributions: (i) Spatial Consistency Enhancement (SCE): volumetric slice composition combined with tri-axial positional embedding that introduces volumetric consistency, and an MoE hybrid projection enables efficient slice-volume adaptation; (ii) Organ-level Semantic Enhancement (OSE): segmentation and ROI localization explicitly align anatomical regions, emphasizing lesion- and organ-level semantics; (iii) MedEval-CT: the largest slice-volume CT dataset and hybrid benchmark integrates comprehensive metrics for unified evaluation. OmniCT consistently outperforms existing methods with a substantial margin across diverse clinical tasks and satisfies both micro-level detail sensitivity and macro-level spatial reasoning. More importantly, it establishes a new paradigm for cross-modal medical imaging understanding. Our project is available at https://github.com/ZJU4HealthCare/OmniCT.

We address the problem of cross-domain image registration, where paired images exhibit coupled geometric misalignment and domain-specific appearance shift. We formalize this as a factorization problem: decomposing each image into a domain-invariant scene representation and a global appearance statistic, such that registration reduces to recombining the scene structure of the moving image with the appearance of the fixed image via Adaptive Instance Normalization (AdaIN). This factorization eliminates the need for explicit deformation field estimation. To exploit temporal coherence in sequential acquisitions, we introduce a position-encoded cross-frame attention mechanism that fuses learnable and sinusoidal position embeddings with multi-head attention over a sliding window of neighboring frames, enriching the scene representation with inter-frame context. We instantiate this framework as GPEReg-Net and evaluate on two benchmarks: FIRE-Reg-256 (retinal fundus, semi-rigid) and HPatches-Reg-256 (synthetic textured patches, affine). GPEReg-Net achieves state-of-the-art performance on both benchmarks (FIRE: SSIM = 0.928, PSNR = 33.47 dB; HPatches: SSIM = 0.450, PSNR = 21.01 dB), surpassing all baselines, including deformation-based methods, while running 1.87x faster than SAS-Net. Code: https://github.com/JiahaoQin/GPEReg-Net.

Large Language Models (LLMs) are trained with next-token prediction, implemented in autoregressive Transformers via causal masking for parallelism. This creates a subtle misalignment: residual connections tie activations to the current token, while supervision targets the next token, potentially propagating mismatched information if the current token is not the most informative for prediction. In this work, we empirically localize this input-output alignment shift in pretrained LLMs, using decoding trajectories over tied embedding spaces and similarity-based metrics. Our experiments reveal that the hidden token representations switch from input alignment to output alignment deep within the network. Motivated by this observation, we propose a lightweight residual-path mitigation based on residual attenuation, implemented either as a fixed-layer intervention or as a learnable gating mechanism. Experiments on multiple benchmarks show that these strategies alleviate the representation misalignment and yield improvements, providing an efficient and general architectural enhancement for autoregressive Transformers.

Deep Learning architectures, and in particular Transformers, are conventionally viewed as a composition of layers. These layers are actually often obtained as the sum of two contributions: a residual path that copies the input and the output of a Transformer block. As a consequence, the inner representations (i.e. the input of these blocks) can be interpreted as iterative refinement of a propagated latent representation. Under this lens, many works suggest that the inner space is shared across layers, meaning that tokens can be decoded at early stages. Mechanistic interpretability even goes further by conjecturing that some layers act as refinement layers. Following this path, we propose inference-time inner looping, which prolongs refinement in pretrained off-the-shelf language models by repeatedly re-applying a selected block range. Across multiple benchmarks, inner looping yields modest but consistent accuracy improvements. Analyses of the resulting latent trajectories suggest more stable state evolution and continued semantic refinement. Overall, our results suggest that additional refinement can be obtained through simple test-time looping, extending computation in frozen pretrained models.

Large language models struggle to maintain strict adherence to structured workflows in high-stakes domains such as healthcare triage. Monolithic approaches that encode entire decision structures within a single prompt are prone to instruction-following degradation as prompt length increases, including lost-in-the-middle effects and context window overflow. To address this gap, we present Arbor, a framework that decomposes decision tree navigation into specialized, node-level tasks. Decision trees are standardized into an edge-list representation and stored for dynamic retrieval. At runtime, a directed acyclic graph (DAG)-based orchestration mechanism iteratively retrieves only the outgoing edges of the current node, evaluates valid transitions via a dedicated LLM call, and delegates response generation to a separate inference step. The framework is agnostic to the underlying decision logic and model provider. Evaluated against single-prompt baselines across 10 foundation models using annotated turns from real clinical triage conversations. Arbor improves mean turn accuracy by 29.4 percentage points, reduces per-turn latency by 57.1%, and achieves an average 14.4x reduction in per-turn cost. These results indicate that architectural decomposition reduces dependence on intrinsic model capability, enabling smaller models to match or exceed larger models operating under single-prompt baselines.

Current alignment methods for Large Language Models (LLMs) rely on compressing vast amounts of human preference data into static, absolute reward functions, leading to data scarcity, noise sensitivity, and training instability. We introduce Elo-Evolve, a co-evolutionary framework that redefines alignment as dynamic multi-agent competition within an adaptive opponent pool. Our approach makes two key innovations: (1) eliminating Bradley-Terry model dependencies by learning directly from binary win/loss outcomes in pairwise competitions, and (2) implementing Elo-orchestrated opponent selection that provides automatic curriculum learning through temperature-controlled sampling. We ground our approach in PAC learning theory, demonstrating that pairwise comparison achieves superior sample complexity and empirically validate a 4.5x noise reduction compared to absolute scoring approaches. Experimentally, we train a Qwen2.5-7B model using our framework with opponents including Qwen2.5-14B, Qwen2.5-32B, and Qwen3-8B models. Results demonstrate a clear performance hierarchy: point-based methods < static pairwise training < Elo-Evolve across Alpaca Eval 2.0 and MT-Bench, validating the progressive benefits of pairwise comparison and dynamic opponent selection for LLM alignment.

Reward models are crucial for aligning large language models (LLMs) with human values and intentions. Existing approaches follow either Generative (GRMs) or Discriminative (DRMs) paradigms, yet both suffer from limitations: GRMs typically demand costly point-wise supervision, while DRMs produce uncalibrated relative scores that lack probabilistic interpretation. To address these challenges, we introduce a novel reward modeling paradigm: Probabilistic Reward Model (PRM). Instead of modeling reward as a deterministic scalar, our approach treats it as a random variable, learning a full probability distribution for the quality of each response. To make this paradigm practical, we present its closed-form, discrete realization: the Ordinal Probabilistic Reward Model (OPRM), which discretizes the quality score into a finite set of ordinal ratings. Building on OPRM, we propose a data-efficient training strategy called Region Flooding Tuning (RgFT). It enables rewards to better reflect absolute text quality by incorporating quality-level annotations, which guide the model to concentrate the probability mass within corresponding rating sub-regions. Experiments on various reward model benchmarks show that our method improves accuracy by $\textbf{2.9%}\sim\textbf{7.4%}$ compared to prior reward models, demonstrating strong performance and data efficiency. Analysis of the score distribution provides evidence that our method captures not only relative rankings but also absolute quality.

Self-supervised learning (SSL) is a powerful paradigm for learning from unlabeled time-series data. However, popular methods such as masked autoencoders (MAEs) rely on reconstructing inputs from a fixed, predetermined masking ratio. Instead of this static design, we propose treating the corruption level as a new degree of freedom for representation learning, enhancing flexibility and performance. To achieve this, we introduce the Flow-Guided Neural Operator (FGNO), a novel framework combining operator learning with flow matching for SSL training. FGNO learns mappings in functional spaces by using Short-Time Fourier Transform to unify different time resolutions. We extract a rich hierarchy of features by tapping into different network layers and flow times that apply varying strengths of noise to the input data. This enables the extraction of versatile representations, from low-level patterns to high-level global features, using a single model adaptable to specific tasks. Unlike prior generative SSL methods that use noisy inputs during inference, we propose using clean inputs for representation extraction while learning representations with noise; this eliminates randomness and boosts accuracy. We evaluate FGNO across three biomedical domains, where it consistently outperforms established baselines. Our method yields up to 35% AUROC gains in neural signal decoding (BrainTreeBank), 16% RMSE reductions in skin temperature prediction (DREAMT), and over 20% improvement in accuracy and macro-F1 on SleepEDF under low-data regimes. These results highlight FGNO's robustness to data scarcity and its superior capacity to learn expressive representations for diverse time series.

While reinforcement learning for large language model alignment has progressed rapidly in recent years, transferring these paradigms to high-stakes medical question answering reveals a fundamental paradigm mismatch. Reinforcement Learning from Human Feedback relies on preference annotations that are prohibitively expensive and often fail to reflect the absolute correctness of medical facts. Reinforcement Learning from Verifiable Rewards lacks effective automatic verifiers and struggles to handle complex clinical contexts. Meanwhile, medical alignment requires the simultaneous optimization of correctness, safety, and compliance, yet multi-objective heterogeneous reward signals are prone to scale mismatch and optimization conflicts. To address these challenges, we propose a robust medical alignment paradigm. We first construct a holistic multi-dimensional medical alignment matrix that decomposes alignment objectives into four categories: fundamental capabilities, expert knowledge, online feedback, and format specifications. Within each category, we establish a closed loop of where observable metrics inform attributable diagnosis, which in turn drives optimizable rewards, thereby providing fine-grained, high-resolution supervision signals for subsequent iterative optimization. To resolve gradient domination and optimization instability problem caused by heterogeneous signals, we further propose a unified optimization mechanism. This mechanism employs Reference-Frozen Normalization to align reward scales and implements a Tri-Factor Adaptive Dynamic Weighting strategy to achieve collaborative optimization that is weakness-oriented, risk-prioritized, and redundancy-reducing. Experimental results demonstrate the effectiveness of our proposed paradigm in real-world medical scenario evaluations, establishing a new paradigm for complex alignment in vertical domains.

Reinforcement learning for large language models suffers from high-variance token-level importance sampling (IS) ratios, which would destabilize policy optimization at scale. To improve stability, recent methods typically use a fixed sequence-level IS ratio for all tokens in a sequence or adjust each token's IS ratio separately, thereby neglecting temporal off-policy derivation across tokens in a sequence. In this paper, we first empirically identify that local off-policy deviation is structurally inconsistent at the token level, which may distort policy-gradient updates across adjacent tokens and lead to training collapse. To address the issue, we propose Online Causal Kalman Filtering for stable and effective Policy Optimization (KPO). Concretely, we model the desired IS ratio as a latent state that evolves across tokens and apply a Kalman filter to update this state online and autoregressively based on the states of past tokens, regardless of future tokens. The resulting filtered IS ratios preserve token-wise local structure-aware variation while strongly smoothing noise spikes, yielding more stable and effective policy updates. Experimentally, KPO achieves superior results on challenging math reasoning datasets compared with state-of-the-art counterparts.

Large Vision-Language Models (LVLMs) have demonstrated strong reasoning capabilities in geo-localization, yet they often struggle in real-world scenarios where visual cues are sparse, long-tailed, and highly ambiguous. Previous approaches, bound by internal knowledge, often fail to provide verifiable results, yielding confident but ungrounded predictions when faced with confounded evidence. To address these challenges, we propose SpotAgent, a framework that formalizes geo-localization into an agentic reasoning process that leverages expert-level reasoning to synergize visual interpretation with tool-assisted verification. SpotAgent actively explores and verifies visual cues by leveraging external tools (e.g., web search, maps) through a ReAct diagram. We introduce a 3-stage post-training pipeline starting with a Supervised Fine-Tuning (SFT) stage for basic alignment, followed by an Agentic Cold Start phase utilizing high-quality trajectories synthesized via a Multi-Agent framework, aiming to instill tool-calling expertise. Subsequently, the model's reasoning capabilities are refined through Reinforcement Learning. We propose a Spatially-Aware Dynamic Filtering strategy to enhance the efficiency of the RL stage by prioritizing learnable samples based on spatial difficulty. Extensive experiments on standard benchmarks demonstrate that SpotAgent achieves state-of-the-art performance, effectively mitigating hallucinations while delivering precise and verifiable geo-localization.

Reinforcement Learning with Verifiable Rewards~(RLVR) has become a prominent paradigm to enhance the capabilities (i.e.\ long-context) of Large Language Models~(LLMs). However, it often relies on gold-standard answers or explicit evaluation rubrics provided by powerful teacher models or human experts, which are costly and time-consuming. In this work, we investigate unsupervised approaches to enhance the long-context capabilities of LLMs, eliminating the need for heavy human annotations or teacher models' supervision. Specifically, we first replace a few paragraphs with special placeholders in a long document. LLMs are trained through reinforcement learning to reconstruct the document by correctly identifying and sequencing missing paragraphs from a set of candidate options. This training paradigm enables the model to capture global narrative coherence, significantly boosting long-context performance. We validate the effectiveness of our method on two widely used benchmarks, RULER and LongBench~v2. While acquiring noticeable gains on RULER, it can also achieve a reasonable improvement on LongBench~v2 without any manually curated long-context QA data. Furthermore, we conduct extensive ablation studies to analyze the impact of reward design, data curation strategies, training schemes, and data scaling effects on model performance. We publicly release our code, data, and models.

Material synthesis planning (MSP) remains a fundamental and underexplored bottleneck in AI-driven materials discovery, as it requires not only identifying suitable precursor materials but also designing coherent sequences of synthesis operations to realize a target material. Although several AI-based approaches have been proposed to address isolated subtasks of MSP, a unified methodology for solving the entire MSP task has yet to be established. We propose MSP-LLM, a unified LLM-based framework that formulates MSP as a structured process composed of two constituent subproblems: precursor prediction (PP) and synthesis operation prediction (SOP). Our approach introduces a discrete material class as an intermediate decision variable that organizes both tasks into a chemically consistent decision chain. For SOP, we further incorporate hierarchical precursor types as synthesis-relevant inductive biases and employ an explicit conditioning strategy that preserves precursor-related information in the autoregressive decoding state. Extensive experiments show that MSP-LLM consistently outperforms existing methods on both PP and SOP, as well as on the complete MSP task, demonstrating an effective and scalable framework for MSP that can accelerate real-world materials discovery.