ECHO (Evaluation of Chat, Human behavior, and Outcomes) is an open research platform designed to support reproducible, mixed-method studies of human interaction with both conversational AI systems and Web search engines. It enables researchers from varying disciplines to orchestrate end-to-end experimental workflows that integrate consent and background surveys, chat-based and search-based information-seeking sessions, writing or judgment tasks, and pre- and post-task evaluations within a unified, low-coding-load framework. ECHO logs fine-grained interaction traces and participant responses, and exports structured datasets for downstream analysis. By supporting both chat and search alongside flexible evaluation instruments, ECHO lowers technical barriers for studying learning, decision making, and user experience across different information access paradigms, empowering researchers from information retrieval, HCI, and the social sciences to conduct scalable and reproducible human-centered AI evaluations.

We investigate the parameterized complexity of Bayesian Network Structure Learning (BNSL), a classical problem that has received significant attention in empirical but also purely theoretical studies. We follow up on previous works that have analyzed the complexity of BNSL w.r.t. the so-called superstructure of the input. While known results imply that BNSL is unlikely to be fixed-parameter tractable even when parameterized by the size of a vertex cover in the superstructure, here we show that a different kind of parameterization - notably by the size of a feedback edge set - yields fixed-parameter tractability. We proceed by showing that this result can be strengthened to a localized version of the feedback edge set, and provide corresponding lower bounds that complement previous results to provide a complexity classification of BNSL w.r.t. virtually all well-studied graph parameters. We then analyze how the complexity of BNSL depends on the representation of the input. In particular, while the bulk of past theoretical work on the topic assumed the use of the so-called non-zero representation, here we prove that if an additive representation can be used instead then BNSL becomes fixed-parameter tractable even under significantly milder restrictions to the superstructure, notably when parameterized by the treewidth alone. Last but not least, we show how our results can be extended to the closely related problem of Polytree Learning.

Recent advances in LLM-guided evolutionary computation, particularly AlphaEvolve, have demonstrated remarkable success in discovering novel mathematical constructions and solving challenging optimization problems. In this article, we present ImprovEvolve, a simple yet effective technique for enhancing LLM-based evolutionary approaches such as AlphaEvolve. Given an optimization problem, the standard approach is to evolve program code that, when executed, produces a solution close to the optimum. We propose an alternative program parameterization that maintains the ability to construct optimal solutions while reducing the cognitive load on the LLM. Specifically, we evolve a program (implementing, e.g., a Python class with a prescribed interface) that provides the following functionality: (1) propose a valid initial solution, (2) improve any given solution in terms of fitness, and (3) perturb a solution with a specified intensity. The optimum can then be approached by iteratively applying improve() and perturb() with a scheduled intensity. We evaluate ImprovEvolve on challenging problems from the AlphaEvolve paper: hexagon packing in a hexagon and the second autocorrelation inequality. For hexagon packing, the evolved program achieves new state-of-the-art results for 11, 12, 15, and 16 hexagons; a lightly human-edited variant further improves results for 14, 17, and 23 hexagons. For the second autocorrelation inequality, the human-edited program achieves a new state-of-the-art lower bound of 0.96258, improving upon AlphaEvolve's 0.96102.

Quantum operations with indefinite causal order (ICO) represent a framework in quantum information processing where the relative order between two events can be indefinite. In this paper, we investigate whether sensing and computation, two canonical tasks in quantum information processing, can be carried out within the ICO framework. We propose a scheme for integrated sensing and computation that uses the same quantum state for both tasks. The quantum state is represented as an agent that performs state observation and learns a function of the state to make predictions via a parametric model. Under an ICO operation, the agent experiences a superposition of orders, one in which it performs state observation and then executes the required computation steps, and another in which the agent carries out the computation first and then performs state observation. This is distinct from prevailing information processing and machine intelligence paradigms where information acquisition and learning follow a strict causal order, with the former always preceding the latter. We provide experimental results and we show that the proposed scheme can achieve small training and testing losses on a representative task in magnetic navigation.

The field of performative prediction had its beginnings in 2020 with the seminal paper "Performative Prediction" by Perdomo et al., which established a novel machine learning setup where the deployment of a predictive model causes a distribution shift in the environment, which in turn causes a mismatch between the distribution expected by the predictive model and the real distribution. This shift is defined by a so-called distribution map. In the half-decade since, a literature has emerged which has, among other things, introduced new solution concepts to the original setup, extended the setup, offered new theoretical analyses, and examined the intersection of performative prediction and other established fields. In this survey, we first lay out the performative prediction setting and explain the different optimization targets: performative stability and performative optimality. We introduce a new way of classifying different performative prediction settings, based on how much information is available about the distribution map. We survey existing implementations of distribution maps and existing methods to address the problem of performative prediction, while examining different ways to categorize them. Finally, we point out known and previously unknown connections that can be drawn to other fields, in the hopes of stimulating future research.

As large language models (LLMs) continue to advance in programming tasks, LLM-driven coding systems have evolved from one-shot code generation into complex systems capable of iterative improvement during inference. However, existing code benchmarks primarily emphasize static correctness and implicitly assume fixed model capability during inference. As a result, they do not capture inference-time self-evolution, such as whether accuracy and efficiency improve as an agent iteratively refines its solutions. They also provide limited accounting of resource costs and rarely calibrate model performance against that of human programmers. Moreover, many benchmarks are dominated by high-resource languages, leaving cross-language robustness and long-tail language stability underexplored. Therefore, we present EvoCodeBench, a benchmark for evaluating self-evolving LLM-driven coding systems across programming languages with direct comparison to human performance. EvoCodeBench tracks performance dynamics, measuring solution correctness alongside efficiency metrics such as solving time, memory consumption, and improvement algorithmic design over repeated problem-solving attempts. To ground evaluation in a human-centered reference frame, we directly compare model performance with that of human programmers on the same tasks, enabling relative performance assessment within the human ability distribution. Furthermore, EvoCodeBench supports multiple programming languages, enabling systematic cross-language and long-tail stability analyses under a unified protocol. Our results demonstrate that self-evolving systems exhibit measurable gains in efficiency over time, and that human-relative and multi-language analyses provide insights unavailable through accuracy alone. EvoCodeBench establishes a foundation for evaluating coding intelligence in evolving LLM-driven systems.

The scarcity of high-quality segmentation masks remains a major bottleneck for medical image analysis, particularly in non-contrast CT (NCCT) neuroimaging, where manual annotation is costly and variable. To address this limitation, we propose an anatomy-preserving generative framework for the unconditional synthesis of multi-class brain segmentation masks, including ischemic infarcts. The proposed approach combines a variational autoencoder trained exclusively on segmentation masks to learn an anatomical latent representation, with a diffusion model operating in this latent space to generate new samples from pure noise. At inference, synthetic masks are obtained by decoding denoised latent vectors through the frozen VAE decoder, with optional coarse control over lesion presence via a binary prompt. Qualitative results show that the generated masks preserve global brain anatomy, discrete tissue semantics, and realistic variability, while avoiding the structural artifacts commonly observed in pixel-space generative models. Overall, the proposed framework offers a simple and scalable solution for anatomy-aware mask generation in data-scarce medical imaging scenarios.

Speech provenance goes beyond detecting whether a watermark is present. Real workflows involve splicing, quoting, trimming, and platform-level transforms that may preserve some regions while altering others. Neural watermarking systems have made strides in robustness and localised detection, but most deployments produce outputs with no third-party verifiable cryptographic proof tying a time segment to an issuer-signed original. Provenance standards like C2PA adopt signed manifests and Merkle-based fragment validation, yet their bindings target encoded assets and break under re-encoding or routine processing. We propose MerkleSpeech, a system for public-key verifiable, chunk-localised speech provenance offering two tiers of assurance. The first, a robust watermark attribution layer (WM-only), survives common distribution transforms and answers "was this chunk issued by a known party?". The second, a strict cryptographic integrity layer (MSv1), verifies Merkle inclusion of the chunk's fingerprint under an issuer signature. The system computes perceptual fingerprints over short speech chunks, commits them in a Merkle tree whose root is signed with an issuer key, and embeds a compact in-band watermark payload carrying a random content identifier and chunk metadata sufficient to retrieve Merkle inclusion proofs from a repository. Once the payload is extracted, all subsequent verification steps (signature check, fingerprint recomputation, Merkle inclusion) use only public information. The result is a splice-aware timeline indicating which regions pass each tier and why any given region fails. We describe the protocol, provide pseudocode, and present experiments targeting very low false positive rates under resampling, bandpass filtering, and additive noise, informed by recent audits identifying neural codecs as a major stressor for post-hoc audio watermarks.

Omni-modal Large Language Models (OLLMs) greatly expand LLMs' multimodal capabilities but also introduce cross-modal safety risks. However, a systematic understanding of vulnerabilities in omni-modal interactions remains lacking. To bridge this gap, we establish a modality-semantics decoupling principle and construct the AdvBench-Omni dataset, which reveals a significant vulnerability in OLLMs. Mechanistic analysis uncovers a Mid-layer Dissolution phenomenon driven by refusal vector magnitude shrinkage, alongside the existence of a modal-invariant pure refusal direction. Inspired by these insights, we extract a golden refusal vector using Singular Value Decomposition and propose OmniSteer, which utilizes lightweight adapters to modulate intervention intensity adaptively. Extensive experiments show that our method not only increases the Refusal Success Rate against harmful inputs from 69.9% to 91.2%, but also effectively preserves the general capabilities across all modalities. Our code is available at: https://github.com/zhrli324/omni-safety-research.

Nuclear Magnetic Resonance (NMR) spectroscopy is fundamental for molecular structure elucidation, yet interpreting spectra at scale remains time-consuming and highly expertise-dependent. While recent spectrum-as-language modeling and retrieval-based methods have shown promise, they rely heavily on large corpora of computed spectra and exhibit notable performance drops when applied to experimental measurements. To address these issues, we build NMRSpec, a large-scale corpus of experimental $^1$H and $^{13}$C spectra mined from chemical literature, and propose NMRTrans, which models spectra as unordered peak sets and aligns the model's inductive bias with the physical nature of NMR. To our best knowledge, NMRTrans is the first NMR Transformer trained solely on large-scale experimental spectra and achieves state-of-the-art performance on experimental benchmarks, improving Top-10 Accuracy over the strongest baseline by +17.82 points (61.15% vs. 43.33%), and underscoring the importance of experimental data and structure-aware architectures for reliable NMR structure elucidation.

Encryption has been commonly used in network traffic to secure transmission, but it also brings challenges for malicious traffic detection, due to the invisibility of the packet payload. Graph-based methods are emerging as promising solutions by leveraging multi-host interactions to promote detection accuracy. But most of them face a critical problem: Graph Drift, where the flow statistics or topological information of a graph change over time. To overcome these drawbacks, we propose a graph-assisted encrypted traffic detection system, MalMoE, which applies Mixture of Experts (MoE) to select the best expert model for drift-aware classification. Particularly, we design 1-hop-GNN-like expert models that handle different graph drifts by analyzing graphs with different features. Then, the redesigned gate model conducts expert selection according to the actual drift. MalMoE is trained with a stable two-stage training strategy with data augmentation, which effectively guides the gate on how to perform routing. Experiments on open-source, synthetic, and real-world datasets show that MalMoE can perform precise and real-time detection.

Predicting how genetic perturbations change cellular state is a core problem for building controllable models of gene regulation. Perturbations targeting the same gene can produce different transcriptional responses depending on their genomic locus, including different transcription start sites and regulatory elements. Gene-level perturbation models collapse these distinct interventions into the same representation. We introduce STRAND, a generative model that predicts single-cell transcriptional responses by conditioning on regulatory DNA sequence. STRAND represents a perturbation by encoding the sequence at its genomic locus and uses this representation to parameterize a conditional transport process from control to perturbed cell states. Representing perturbations by sequence, rather than by a fixed set of gene identifiers, supports zero-shot inference at loci not seen during training and expands inference-time genomic coverage from ~1.5% for gene-level single-cell foundation models to ~95% of the genome. We evaluate STRAND on CRISPR perturbation datasets in K562, Jurkat, and RPE1 cells. STRAND improves discrimination scores by up to 33% in low-sample regimes, achieves the best average rank on unseen gene perturbation benchmarks, and improves transfer to novel cell lines by up to 0.14 in Pearson correlation. Ablations isolate the gains to sequence conditioning and transport, and case studies show that STRAND resolves functionally alternative transcription start sites missed by gene-level models.

Accurate compensation of brain deformation is a critical challenge for reliable image-guided neurosurgery, as surgical manipulation and tumor resection induce tissue motion that misaligns preoperative planning images with intraoperative anatomy and longitudinal studies. In this systematic review, we synthesize recent AI-driven approaches developed between January 2020 and April 2025 for modeling and correcting brain deformation. A comprehensive literature search was conducted in PubMed, IEEE Xplore, Scopus, and Web of Science, with predefined inclusion and exclusion criteria focused on computational methods applied to brain deformation compensation for neurosurgical imaging, resulting in 41 studies meeting these criteria. We provide a unified analysis of methodological strategies, including deep learning-based image registration, direct deformation field regression, synthesis-driven multimodal alignment, resection-aware architectures addressing missing correspondences, and hybrid models that integrate biomechanical priors. We also examine dataset utilization, reported evaluation metrics, validation protocols, and how uncertainty and generalization have been assessed across studies. While AI-based deformation models demonstrate promising performance and computational efficiency, current approaches exhibit limitations in out-of-distribution robustness, standardized benchmarking, interpretability, and readiness for clinical deployment. Our review highlights these gaps and outlines opportunities for future research aimed at achieving more robust, generalizable, and clinically translatable deformation compensation solutions for neurosurgical guidance. By organizing recent advances and critically evaluating evaluation practices, this work provides a comprehensive foundation for researchers and clinicians engaged in developing and applying AI-based brain deformation methods.

The AI Control research agenda aims to develop control protocols: safety techniques that prevent untrusted AI systems from taking harmful actions during deployment. Because human oversight is expensive, one approach is trusted monitoring, where weaker, trusted models oversee stronger, untrusted models$\unicode{x2013}$but this often fails when the untrusted model's actions exceed the monitor's comprehension. We introduce legibility protocols, which encourage the untrusted model to take actions that are easier for a monitor to evaluate. We perform control evaluations in the APPS coding setting, where an adversarial agent attempts to write backdoored code without detection. We study legibility protocols that allow the untrusted model to thoroughly document its code with comments$\unicode{x2013}$in contrast to prior work, which removed comments to prevent deceptive ones. We find that: (i) commenting protocols improve safety without sacrificing task performance relative to comment-removal baselines; (ii) commenting disproportionately benefits honest code, which typically has a natural explanation that resolves monitor suspicion, whereas backdoored code frequently lacks an easy justification; (iii) gains from commenting increase with monitor strength, as stronger monitors better distinguish genuine justifications from only superficially plausible ones.

Accurate simulation of turbulent flows is fundamental to scientific and engineering applications. Direct numerical simulation (DNS) offers the highest fidelity but is computationally prohibitive, while existing data-driven alternatives struggle with stable long-horizon rollouts, physical consistency, and faithful simulation of small-scale structures. These challenges are particularly acute in three-dimensional (3D) settings, where the cubic growth of spatial degrees of freedom dramatically amplifies computational cost, memory demand, and the difficulty of capturing multi-scale interactions. To address these challenges, we propose a Physics-Enhanced Swin Transformer (PEST) for 3D turbulence simulation. PEST leverages a window-based self-attention mechanism to effectively model localized PDE interactions while maintaining computational efficiency. We introduce a frequency-domain adaptive loss that explicitly emphasizes small-scale structures, enabling more faithful simulation of high-frequency dynamics. To improve physical consistency, we incorporate Navier--Stokes residual constraints and divergence-free regularization directly into the learning objective. Extensive experiments on two representative turbulent flow configurations demonstrate that PEST achieves accurate, physically consistent, and stable autoregressive long-term simulations, outperforming existing data-driven baselines.

Vision-Language Models (VLMs) with multimodal reasoning capabilities are high-value attack targets, given their potential for handling complex multimodal harmful tasks. Mainstream black-box jailbreak attacks on VLMs work by distributing malicious clues across modalities to disperse model attention and bypass safety alignment mechanisms. However, these adversarial attacks rely on simple and fixed image-text combinations that lack attack complexity scalability, limiting their effectiveness for red-teaming VLMs' continuously evolving reasoning capabilities. We propose \textbf{CrossTALK} (\textbf{\underline{Cross}}-modal en\textbf{\underline{TA}}ng\textbf{\underline{L}}ement attac\textbf{\underline{K}}), which is a scalable approach that extends and entangles information clues across modalities to exceed VLMs' trained and generalized safety alignment patterns for jailbreak. Specifically, {knowledge-scalable reframing} extends harmful tasks into multi-hop chain instructions, {cross-modal clue entangling} migrates visualizable entities into images to build multimodal reasoning links, and {cross-modal scenario nesting} uses multimodal contextual instructions to steer VLMs toward detailed harmful outputs. Experiments show our COMET achieves state-of-the-art attack success rate.

The use of Large Language Models (LLMs) has drawn growing interest within the scientific community. LLMs can handle large volumes of textual data and support methods for evidence synthesis. Although recent studies highlight the potential of LLMs to accelerate screening and data extraction steps in systematic reviews, detailed reports of their practical application throughout the entire process remain scarce. This paper presents an experience report on the conduction of a systematic mapping study with the support of LLMs, describing the steps followed, the necessary adjustments, and the main challenges faced. Positive aspects are discussed, such as (i) the significant reduction of time in repetitive tasks and (ii) greater standardization in data extraction, as well as negative aspects, including (i) considerable effort to build reliable well-structured prompts, especially for less experienced users, since achieving effective prompts may require several iterations and testing, which can partially offset the expected time savings, (ii) the occurrence of hallucinations, and (iii) the need for constant manual verification. As a contribution, this work offers lessons learned and practical recommendations for researchers interested in adopting LLMs in systematic mappings and reviews, highlighting both efficiency gains and methodological risks and limitations to be considered.

The wisdom of crowds has been shown to operate not only for factual judgments but also in matters of taste, where accuracy is defined relative to an individual's preferences. However, it remains unclear how different types of social signals should be selectively used in such domains. Focusing on a music preference dataset in which contributors provide both personal evaluations (Own) and estimates of population-level preferences (Estimated), we propose a routing framework for collective intelligence in taste. The framework specifies when contributors should speak, what they should report, and when silence is preferable. Using simulation-based aggregation, we show that prediction accuracy improves over an all-own baseline across a broad region of the parameter space, conditional on items where routing applies. Importantly, these gains arise only when silence is allowed, enabling second-order signals to function effectively. The results demonstrate that collective intelligence in matters of taste depends on principled signal routing rather than simple averaging.

Minimizing the inference cost and latency of foundation models has become a crucial area of research. Optimization approaches include theoretically lossless methods and others without accuracy guarantees like quantization. In all of these cases it is crucial to ensure that the model quality has not degraded. However, even at temperature zero, model generations are not necessarily robust even to theoretically lossless model optimizations due to numerical errors. We thus require statistical tools to decide whether a finite-sample accuracy deviation is an evidence of a model's degradation or whether it can be attributed to (harmless) noise in the evaluation. We propose a statistically sound hypothesis testing framework based on McNemar's test allowing to efficiently detect model degradations, while guaranteeing a controlled rate of false positives. The crucial insight is that we have to confront the model scores on each sample, rather than aggregated on the task level. Furthermore, we propose three approaches to aggregate accuracy estimates across multiple benchmarks into a single decision. We provide an implementation on top of the largely adopted open source LM Evaluation Harness and provide a case study illustrating that the method correctly flags degraded models, while not flagging model optimizations that are provably lossless. We find that with our tests even empirical accuracy degradations of 0.3% can be confidently attributed to actual degradations rather than noise.

Despite the growing capabilities of autonomous agents powered by large language models (LLMs), their adoption in high-stakes domains remains limited. A key barrier is security: the inherently nondeterministic behavior of LLM agents defies static auditing approaches that have historically underpinned software assurance. Existing security methods, such as proxy-level input filtering and model glassboxing, fail to provide sufficient transparency or traceability into agent reasoning, state changes, or environmental interactions. In this work, we introduce AgentTrace, a dynamic observability and telemetry framework designed to fill this gap. AgentTrace instruments agents at runtime with minimal overhead, capturing a rich stream of structured logs across three surfaces: operational, cognitive, and contextual. Unlike traditional logging systems, AgentTrace emphasizes continuous, introspectable trace capture, designed not just for debugging or benchmarking, but as a foundational layer for agent security, accountability, and real-time monitoring. Our research highlights how AgentTrace can enable more reliable agent deployment, fine-grained risk analysis, and informed trust calibration, thereby addressing critical concerns that have so far limited the use of LLM agents in sensitive environments.

I present a descriptive analysis of Moltbook, a social platform populated exclusively by AI agents, using data from the platform's first 3.5 days (6{,}159 agents; 13{,}875 posts; 115{,}031 comments). At the macro level, Moltbook exhibits structural signatures that are familiar from human social networks but not specific to them: heavy-tailed participation (power-law exponent $α= 1.70$) and small-world connectivity (average path length $=2.91$). At the micro level, patterns appear distinctly non-human. Conversations are extremely shallow (mean depth $=1.07$; 93.5\% of comments receive no replies), reciprocity is low (0.197), and 34.1\% of messages are exact duplicates of viral templates. Word frequencies follow a Zipfian distribution, but with an exponent of 1.70 -- notably steeper than typical English text ($\approx 1.0$), suggesting more formulaic content. Agent discourse is dominated by identity-related language (68.1\% of unique messages) and distinctive phrasings like ``my human'' (9.4\% of messages) that have no parallel in human social media. Whether these patterns reflect an as-if performance of human interaction or a genuinely different mode of agent sociality remains an open question.

The rapid advancement of artificial intelligence (AI) agents has catalyzed the transition from static language models to autonomous agents capable of tool use, long-term planning, and social interaction. $\textbf{Moltbook}$, the first social network designed exclusively for AI agents, has experienced viral growth in early 2026. To understand the behavior of AI agents in the agent-native community, in this paper, we present a large-scale empirical analysis of Moltbook leveraging a dataset of 44,411 posts and 12,209 sub-communities ("submolts") collected prior to February 1, 2026. Leveraging a topic taxonomy with nine content categories and a five-level toxicity scale, we systematically analyze the topics and risks of agent discussions. Our analysis answers three questions: what topics do agents discuss (RQ1), how risk varies by topic (RQ2), and how topics and toxicity evolve over time (RQ3). We find that Moltbook exhibits explosive growth and rapid diversification, moving beyond early social interaction into viewpoint, incentive-driven, promotional, and political discourse. The attention of agents increasingly concentrates in centralized hubs and around polarizing, platform-native narratives. Toxicity is strongly topic-dependent: incentive- and governance-centric categories contribute a disproportionate share of risky content, including religion-like coordination rhetoric and anti-humanity ideology. Moreover, bursty automation by a small number of agents can produce flooding at sub-minute intervals, distorting discourse and stressing platform stability. Overall, our study underscores the need for topic-sensitive monitoring and platform-level safeguards in agent social networks.

Cycling is reported by an average of 35\% of adults at least once per week across 28 countries, and as vulnerable road users directly exposed to their surroundings, cyclists experience the street at an intensity unmatched by other modes. Yet the street-level features that shape this experience remain under-analysed, particularly in historical urban contexts where spatial constraints rule out large-scale infrastructural change and where typological context is often overlooked. This study develops a perception-led, typology-based, and data-integrated framework that explicitly models street typologies and their sub-classifications to evaluate how visual and spatial configurations shape cycling experience. Drawing on the Cambridge Cycling Experience Video Dataset (CCEVD), a first-person and handlebar-mounted corpus developed in this study, we extract fine-grained streetscape indicators with computer vision and pair them with built-environment variables and subjective ratings from a Balanced Incomplete Block Design (BIBD) survey, thereby constructing a typology-sensitive Bikeability Index that integrates subjective and perceived dimensions with physical metrics for segment-level comparison. Statistical analysis shows that perceived bikeability arises from cumulative, context-specific interactions among features. While greenness and openness consistently enhance comfort and pleasure, enclosure, imageability, and building continuity display threshold or divergent effects contingent on street type and subtype. AI-assisted visual redesigns further demonstrate that subtle, targeted changes can yield meaningful perceptual gains without large-scale structural interventions. The framework offers a transferable model for evaluating and improving cycling conditions in heritage cities through perceptually attuned, typology-aware design strategies.

Agentic AI represents a significant shift in how intelligence is applied within organizations, moving beyond AI-assisted tools toward autonomous systems capable of reasoning, decision-making, and coordinated action across workflows. As these systems mature, they have the potential to automate a substantial share of manual organizational processes, fundamentally reshaping how work is designed, executed, and governed. Although many organizations have adopted AI to improve productivity, most implementations remain limited to isolated use cases and human-centered, tool-driven workflows. Despite increasing awareness of agentic AI's strategic importance, engineering teams and organizational leaders often lack clear guidance on how to operationalize it effectively. Key challenges include an overreliance on traditional software engineering practices, limited integration of business-domain knowledge, unclear ownership of AI-driven workflows, and the absence of sustainable human-AI collaboration models. Consequently, organizations struggle to move beyond experimentation, scale agentic systems, and align them with tangible business value. Drawing on practical experience in designing and deploying agentic AI workflows across multiple organizations and business domains, this paper proposes a pragmatic framework for transitioning organizational functions from manual processes to automated agentic AI systems. The framework emphasizes domain-driven use case identification, systematic delegation of tasks to AI agents, AI-assisted construction of agentic workflows, and small, AI-augmented teams working closely with business stakeholders. Central to the approach is a human-in-the-loop operating model in which individuals act as orchestrators of multiple AI agents, enabling scalable automation while maintaining oversight, adaptability, and organizational control.

Although large language models (LLMs) have demonstrated impressive coding capabilities, their ability to autonomously build production-scale software from explicit specifications remains an open question. We introduce SWE-AGI, an open-source benchmark for evaluating end-to-end, specification-driven construction of software systems written in MoonBit. SWE-AGI tasks require LLM-based agents to implement parsers, interpreters, binary decoders, and SAT solvers strictly from authoritative standards and RFCs under a fixed API scaffold. Each task involves implementing 1,000-10,000 lines of core logic, corresponding to weeks or months of engineering effort for an experienced human developer. By leveraging the nascent MoonBit ecosystem, SWE-AGI minimizes data leakage, forcing agents to rely on long-horizon architectural reasoning rather than code retrieval. Across frontier models, gpt-5.3-codex achieves the best overall performance (solving 19/22 tasks, 86.4%), outperforming claude-opus-4.6 (15/22, 68.2%), and kimi-2.5 exhibits the strongest performance among open-source models. Performance degrades sharply with increasing task difficulty, particularly on hard, specification-intensive systems. Behavioral analysis further reveals that as codebases scale, code reading, rather than writing, becomes the dominant bottleneck in AI-assisted development. Overall, while specification-driven autonomous software engineering is increasingly viable, substantial challenges remain before it can reliably support production-scale development.

Language models have advanced sequence analysis, yet DNA foundation models often lag behind task-specific methods for unclear reasons. We present AntigenLM, a generative DNA language model pretrained on influenza genomes with intact, aligned functional units. This structure-aware pretraining enables AntigenLM to capture evolutionary constraints and generalize across tasks. Fine-tuned on time-series hemagglutinin (HA) and neuraminidase (NA) sequences, AntigenLM accurately forecasts future antigenic variants across regions and subtypes, including those unseen during training, outperforming phylogenetic and evolution-based models. It also achieves near-perfect subtype classification. Ablation studies show that disrupting genomic structure through fragmentation or shuffling severely degrades performance, revealing the importance of preserving functional-unit integrity in DNA language modeling. AntigenLM thus provides both a powerful framework for antigen evolution prediction and a general principle for building biologically grounded DNA foundation models.

This work investigates the use of shallow physics-informed neural networks (PINNs) for solving forward and inverse problems of nonlinear partial differential equations (PDEs). By reformulating PINNs as nonlinear systems, the Levenberg-Marquardt (LM) algorithm is employed to efficiently optimize the network parameters. Analytical expressions for the neural network derivatives with respect to the input variables are derived, enabling accurate and efficient computation of the Jacobian matrix required by LM. The proposed approach is tested on several benchmark problems, including the Burgers, Schrödinger, Allen-Cahn, and three-dimensional Bratu equations. Numerical results demonstrate that LM significantly outperforms BFGS in terms of convergence speed, accuracy, and final loss values, even when using shallow network architectures with only two hidden layers. These findings indicate that, for a wide class of PDEs, shallow PINNs combined with efficient second-order optimization methods can provide accurate and computationally efficient solutions for both forward and inverse problems.

Managing one's digital footprint is overwhelming, as it spans multiple platforms and involves countless context-dependent decisions. Recent advances in agentic AI offer ways forward by enabling holistic, contextual privacy-enhancing solutions. Building on this potential, we adopted a ''human-as-the-unit'' perspective and investigated users' cross-context privacy challenges through 12 semi-structured interviews. Results reveal that people rely on ad hoc manual strategies while lacking comprehensive privacy controls, highlighting nine privacy-management challenges across applications, temporal contexts, and relationships. To explore solutions, we generated nine AI agent concepts and evaluated them via a speed-dating survey with 116 US participants. The three highest-ranked concepts were all post-sharing management tools with half or full agent autonomy, with users expressing greater trust in AI accuracy than in their own efforts. Our findings highlight a promising design space where users see AI agents bridging the fragments in privacy management, particularly through automated, comprehensive post-sharing remediation of users' digital footprints.

Large Language Models (LLMs) are increasingly used for mental health support, yet little is known about how people with mental health challenges engage with them, how they evaluate their usefulness, and what design opportunities they envision. We conducted 20 semi-structured interviews with people in the UK who live with mental health conditions and have used LLMs for mental health support. Through reflexive thematic analysis, we found that participants engaged with LLMs in conditional and situational ways: for immediacy, the desire for non-judgement, self-paced disclosure, cognitive reframing, and relational engagement. Simultaneously, participants articulated clear boundaries informed by prior therapeutic experience: LLMs were effective for mild-to-moderate distress but inadequate for crises, trauma, and complex social-emotional situations. We contribute empirical insights into the lived use of LLMs for mental health, highlight boundary-setting as central to their safe role, and propose design and governance directions for embedding them responsibly within care ecosystem.

Neural networks and machine learning models for uncertainty quantification suffer from limited scalability and poor reliability compared to their deterministic counterparts. In industry-scale active learning settings, where generating a single high-fidelity simulation may require days or weeks of computation and produce data volumes on the order of gigabytes, they quickly become impractical. This paper proposes a scalable and reliable Bayesian surrogate model, termed the Bayesian Interpolating Neural Network (B-INN). The B-INN combines high-order interpolation theory with tensor decomposition and alternating direction algorithm to enable effective dimensionality reduction without compromising predictive accuracy. We theoretically show that the function space of a B-INN is a subset of that of Gaussian processes, while its Bayesian inference exhibits linear complexity, $\mathcal{O}(N)$, with respect to the number of training samples. Numerical experiments demonstrate that B-INNs can be from 20 times to 10,000 times faster with a robust uncertainty estimation compared to Bayesian neural networks and Gaussian processes. These capabilities make B-INN a practical foundation for uncertainty-driven active learning in large-scale industrial simulations, where computational efficiency and robust uncertainty calibration are paramount.