Split learning is a distributed training paradigm where a neural network is partitioned between clients and a server, which allows data to remain at the client while only intermediate activations are shared. Traditional split learning relies on end-to-end backpropagation across the client-server split point. This incurs a large communication overhead (i.e., forward activations and backward gradients need to be exchanged every iteration) and significant memory use (for storing activations and gradients). In this paper, we develop a beyond-backpropagation training method for split learning. In this approach, the client and server train their model partitions semi-independently, using local loss signals instead of propagated gradients. In particular, the client's network is augmented with a small auxiliary classifier at the split point to provide a local error signal, while the server trains on the client's transmitted activations using the true loss function. This decoupling removes the need to send backward gradients, which cuts communication costs roughly in half and also reduces memory overhead (as each side only stores local activations for its own backward pass). We evaluate our approach on CIFAR-10 and CIFAR-100. Our experiments show two key results. First, the proposed approach achieves performance on par with standard split learning that uses backpropagation. Second, it significantly reduces communication (of transmitting activations/gradient) by 50% and peak memory usage by up to 58%.

Efficient key-value (KV) cache management is crucial for the practical deployment of large language models (LLMs), yet existing compression techniques often incur a trade-off between performance degradation and computational overhead. We propose a novel gating-based KV cache eviction method for frozen-weight LLMs that achieves high compression ratios with negligible computational cost. Our approach introduces lightweight sink-attention gating modules to identify and retain critical KV pairs, and integrates seamlessly into both the prefill and decoding stages. The proposed gate training algorithm relies on forward passes of an LLM, avoiding expensive backpropagation, while achieving strong task generalization through a task-agnostic reconstruction objective. Extensive experiments across the Qwen2.5-1M, Qwen3, and Gemma3 families show that our method maintains near-lossless performance while evicting up to 70% of the KV cache. The results are consistent across a wide range of tasks, including long-context understanding, code comprehension, and mathematical reasoning, demonstrating the generality of our approach.

We present JetFormer, a versatile and scalable encoder-only Transformer architecture for particle jet tagging at the Large Hadron Collider (LHC). Unlike prior approaches that are often tailored to specific deployment regimes, JetFormer is designed to operate effectively across the full spectrum of jet tagging scenarios, from high-accuracy offline analysis to ultra-low-latency online triggering. The model processes variable-length sets of particle features without relying on input of explicit pairwise interactions, yet achieves competitive or superior performance compared to state-of-the-art methods. On the large-scale JetClass dataset, a large-scale JetFormer matches the accuracy of the interaction-rich ParT model (within 0.7%) while using 37.4% fewer FLOPs, demonstrating its computational efficiency and strong generalization. On benchmark HLS4ML 150P datasets, JetFormer consistently outperforms existing models such as MLPs, Deep Sets, and Interaction Networks by 3-4% in accuracy. To bridge the gap to hardware deployment, we further introduce a hardware-aware optimization pipeline based on multi-objective hyperparameter search, yielding compact variants like JetFormer-tiny suitable for FPGA-based trigger systems with sub-microsecond latency requirements. Through structured pruning and quantization, we show that JetFormer can be aggressively compressed with minimal accuracy loss. By unifying high-performance modeling and deployability within a single architectural framework, JetFormer provides a practical pathway for deploying Transformer-based jet taggers in both offline and online environments at the LHC. Code is available at https://github.com/walkieq/JetFormer.

Multi-modal scene reconstruction integrating RGB and thermal infrared data is essential for robust environmental perception across diverse lighting and weather conditions. However, extending 3D Gaussian Splatting (3DGS) to multi-spectral scenarios remains challenging. Current approaches often struggle to fully leverage the complementary information of multi-modal data, typically relying on mechanisms that either tend to neglect cross-modal correlations or leverage shared representations that fail to adaptively handle the complex structural correlations and physical discrepancies between spectrums. To address these limitations, we propose ThermoSplat, a novel framework that enables deep spectral-aware reconstruction through active feature modulation and adaptive geometry decoupling. First, we introduce a Spectrum-Aware Adaptive Modulation that dynamically conditions shared latent features on thermal structural priors, effectively guiding visible texture synthesis with reliable cross-modal geometric cues. Second, to accommodate modality-specific geometric inconsistencies, we propose a Modality-Adaptive Geometric Decoupling scheme that learns independent opacity offsets and executes an independent rasterization pass for the thermal branch. Additionally, a hybrid rendering pipeline is employed to integrate explicit Spherical Harmonics with implicit neural decoding, ensuring both semantic consistency and high-frequency detail preservation. Extensive experiments on the RGBT-Scenes dataset demonstrate that ThermoSplat achieves state-of-the-art rendering quality across both visible and thermal spectrums.

Federated learning is a paradigm of joint learning in which clients collaborate by sharing model parameters instead of data. However, in the non-iid setting, the global model experiences client drift, which can seriously affect the final performance of the model. Previous methods tend to correct the global model that has already deviated based on the loss function or gradient, overlooking the impact of the client samples. In this paper, we rethink the role of the client side and propose Federated Balanced Learning, i.e., FBL, to prevent this issue from the beginning through sample balance on the client side. Technically, FBL allows unbalanced data on the client side to achieve sample balance through knowledge filling and knowledge sampling using edge-side generation models, under the limitation of a fixed number of data samples on clients. Furthermore, we design a Knowledge Alignment Strategy to bridge the gap between synthetic and real data, and a Knowledge Drop Strategy to regularize our method. Meanwhile, we scale our method to real and complex scenarios, allowing different clients to adopt various methods, and extend our framework to further improve performance. Numerous experiments show that our method outperforms state-of-the-art baselines. The code is released upon acceptance.

Existing image-based virtual try-on (VTON) methods primarily focus on single-layer or multi-garment VTON, neglecting multi-layer VTON (ML-VTON), which involves dressing multiple layers of garments onto the human body with realistic deformation and layering to generate visually plausible outcomes. The main challenge lies in accurately modeling occlusion relationships between inner and outer garments to reduce interference from redundant inner garment features. To address this, we propose GO-MLVTON, the first multi-layer VTON method, introducing the Garment Occlusion Learning module to learn occlusion relationships and the StableDiffusion-based Garment Morphing & Fitting module to deform and fit garments onto the human body, producing high-quality multi-layer try-on results. Additionally, we present the MLG dataset for this task and propose a new metric named Layered Appearance Coherence Difference (LACD) for evaluation. Extensive experiments demonstrate the state-of-the-art performance of GO-MLVTON. Project page: https://upyuyang.github.io/go-mlvton/.

Large Language Models (LLMs) struggle to reason over large-scale enterprise spreadsheets containing thousands of numeric rows, multiple linked sheets, and embedded visual content such as charts and receipts. Prior state-of-the-art spreadsheet reasoning approaches typically rely on single-sheet compression or full-context encoding, which limits scalability and fails to reflect how real users interact with complex, multimodal workbooks. We introduce FRTR-Bench, the first large-scale benchmark for multimodal spreadsheet reasoning, comprising 30 enterprise-grade Excel workbooks spanning nearly four million cells and more than 50 embedded images. To address these challenges, we present From Rows to Reasoning (FRTR), an advanced, multimodal retrieval-augmented generation framework that decomposes Excel workbooks into granular row, column, and block embeddings, employs hybrid lexical-dense retrieval with Reciprocal Rank Fusion (RRF), and integrates multimodal embeddings to reason over both numerical and visual information. We tested FRTR on six LLMs, achieving 74% answer accuracy on FRTR-Bench with Claude Sonnet 4.5, a substantial improvement over prior state-of-the-art approaches that reached only 24%. On the SpreadsheetLLM benchmark, FRTR achieved 87% accuracy with GPT-5 while reducing token usage by roughly 50% compared to direct serialization methods.

Unsupervised feature selection aims to identify a compact subset of features that captures the intrinsic structure of data without supervised label. Most existing studies evaluate the performance of methods using the single-label dataset that can be instantiated by selecting a label from multi-label data while maintaining the original features. Because the chosen label can vary arbitrarily depending on the experimental setting, the superiority among compared methods can be changed with regard to which label happens to be selected. Thus, evaluating unsupervised feature selection methods based solely on single-label accuracy is unreasonable for assessing their true discriminative ability. This study revisits this evaluation paradigm by adopting a multi-label classification framework. Experiments on 21 multi-label datasets using several representative methods demonstrate that performance rankings differ markedly from those reported under single-label settings, suggesting the possibility of multi-label evaluation settings for fair and reliable comparison of unsupervised feature selection methods.

Diffusion policies have emerged as a powerful approach for robotic control, demonstrating superior expressiveness in modeling multimodal action distributions compared to conventional policy networks. However, their integration with online reinforcement learning remains challenging due to fundamental incompatibilities between diffusion model training objectives and standard RL policy improvement mechanisms. This paper presents the first comprehensive review and empirical analysis of current Online Diffusion Policy Reinforcement Learning (Online DPRL) algorithms for scalable robotic control systems. We propose a novel taxonomy that categorizes existing approaches into four distinct families--Action-Gradient, Q-Weighting, Proximity-Based, and Backpropagation Through Time (BPTT) methods--based on their policy improvement mechanisms. Through extensive experiments on a unified NVIDIA Isaac Lab benchmark encompassing 12 diverse robotic tasks, we systematically evaluate representative algorithms across five critical dimensions: task diversity, parallelization capability, diffusion step scalability, cross-embodiment generalization, and environmental robustness. Our analysis identifies key findings regarding the fundamental trade-offs inherent in each algorithmic family, particularly concerning sample efficiency and scalability. Furthermore, we reveal critical computational and algorithmic bottlenecks that currently limit the practical deployment of online DPRL. Based on these findings, we provide concrete guidelines for algorithm selection tailored to specific operational constraints and outline promising future research directions to advance the field toward more general and scalable robotic learning systems.

Machine unlearning aims to remove the influence of specific training data from a learned model without full retraining. While recent work has begun to explore unlearning in quantum machine learning, existing approaches largely rely on fixed, uniform target distributions and do not explicitly control the trade-off between forgetting and retained model behaviour. In this work, we propose a distribution-guided framework for class-level quantum machine unlearning that treats unlearning as a constrained optimization problem. Our method introduces a tunable target distribution derived from model similarity statistics, decoupling the suppression of forgotten-class confidence from assumptions about redistribution among retained classes. We further incorporate an anchor-based preservation constraint that explicitly maintains predictive behaviour on selected retained data, yielding a controlled optimization trajectory that limits deviation from the original model. We evaluate the approach on variational quantum classifiers trained on the Iris and Covertype datasets. Results demonstrate sharp suppression of forgotten-class confidence, minimal degradation of retained-class performance, and closer alignment with the gold retrained model baselines compared to uniform-target unlearning. These findings highlight the importance of target design and constraint-based formulations for reliable and interpretable quantum machine unlearning.

Recently, people have suffered from LLM hallucination and have become increasingly aware of the reliability gap of LLMs in open and knowledge-intensive tasks. As a result, they have increasingly turned to search-augmented LLMs to mitigate this issue. However, LLM-driven search also becomes an attractive target for misuse. Once the returned content directly contains targeted, ready-to-use harmful instructions or takeaways for users, it becomes difficult to withdraw or undo such exposure. To investigate LLMs' unsafe search behavior issues, we first propose \textbf{\textit{SearchAttack}} for red-teaming, which (1) rephrases harmful semantics via dense and benign knowledge to evade direct in-context decoding, thus eliciting unsafe information retrieval, (2) stress-tests LLMs' reward-chasing bias by steering them to synthesize unsafe retrieved content. We also curate an emergent, domain-specific illicit activity benchmark for search-based threat assessment, and introduce a fact-checking framework to ground and quantify harm in both offline and online attack settings. Extensive experiments are conducted to red-team the search-augmented LLMs for responsible vulnerability assessment. Empirically, SearchAttack demonstrates strong effectiveness in attacking these systems. We also find that LLMs without web search can still be steered into harmful content output due to their information-seeking stereotypical behaviors.

Municipal meeting minutes record key decisions in local democratic processes. Unlike parliamentary proceedings, which typically adhere to standardized formats, they encode voting outcomes in highly heterogeneous, free-form narrative text that varies widely across municipalities, posing significant challenges for automated extraction. In this paper, we introduce VotIE (Voting Information Extraction), a new information extraction task aimed at identifying structured voting events in narrative deliberative records, and establish the first benchmark for this task using Portuguese municipal minutes, building on the recently introduced CitiLink corpus. Our experiments yield two key findings. First, under standard in-domain evaluation, fine-tuned encoders, specifically XLM-R-CRF, achieve the strongest performance, reaching 93.2\% macro F1, outperforming generative approaches. Second, in a cross-municipality setting that evaluates transfer to unseen administrative contexts, these models suffer substantial performance degradation, whereas few-shot LLMs demonstrate greater robustness, with significantly smaller declines in performance. Despite this generalization advantage, the high computational cost of generative models currently constrains their practicality. As a result, lightweight fine-tuned encoders remain a more practical option for large-scale, real-world deployment. To support reproducible research in administrative NLP, we publicly release our benchmark, trained models, and evaluation framework.

Direct Preference Optimization (DPO) and its variants have become standard for aligning Large Language Models due to their simplicity and offline stability. However, we identify two fundamental limitations. First, the optimal policy depends on arbitrary modeling choices (scalarization function, reference policy), yielding behavior reflecting parameterization artifacts rather than true preferences. Second, treating response generation in isolation fails to leverage comparative information in pairwise data, leaving the model's capacity for intrinsic self-reflection untapped. To address it, we propose Intrinsic Self-reflective Preference Optimization (InSPO), deriving a globally optimal policy conditioning on both context and alternative responses. We prove this formulation superior to DPO/RLHF while guaranteeing invariance to scalarization and reference choices. InSPO serves as a plug-and-play enhancement without architectural changes or inference overhead. Experiments demonstrate consistent improvements in win rates and length-controlled metrics, validating that unlocking self-reflection yields more robust, human-aligned LLMs. Our Code is available at https://github.com/Skylanding/InSPO.

Spiking Neural Networks (SNNs) utilize spike-based activations to mimic the brain's energy-efficient information processing. However, the binary and discontinuous nature of spike activations causes vanishing gradients, making adversarial robustness evaluation via gradient descent unreliable. While improved surrogate gradient methods have been proposed, their effectiveness under strong adversarial attacks remains unclear. We propose a more reliable framework for evaluating SNN adversarial robustness. We theoretically analyze the degree of gradient vanishing in surrogate gradients and introduce the Adaptive Sharpness Surrogate Gradient (ASSG), which adaptively evolves the shape of the surrogate function according to the input distribution during attack iterations, thereby enhancing gradient accuracy while mitigating gradient vanishing. In addition, we design an adversarial attack with adaptive step size under the $L_\infty$ constraint-Stable Adaptive Projected Gradient Descent (SA-PGD), achieving faster and more stable convergence under imprecise gradients. Extensive experiments show that our approach substantially increases attack success rates across diverse adversarial training schemes, SNN architectures and neuron models, providing a more generalized and reliable evaluation of SNN adversarial robustness. The experimental results further reveal that the robustness of current SNNs has been significantly overestimated and highlighting the need for more dependable adversarial training methods. The code is released at https://github.com/craree/ASSG-SNNs-Robustness-Evaluation

Recent query-based 3D object detection methods using camera and LiDAR inputs have shown strong performance, but existing query initialization strategies,such as random sampling or BEV heatmap-based sampling, often result in inefficient query usage and reduced accuracy, particularly for occluded or crowded objects. To address this limitation, we propose ALIGN (Advanced query initialization with LiDAR and Image GuidaNce), a novel approach for occlusion-robust, object-aware query initialization. Our model consists of three key components: (i) Occlusion-aware Center Estimation (OCE), which integrates LiDAR geometry and image semantics to estimate object centers accurately (ii) Adaptive Neighbor Sampling (ANS), which generates object candidates from LiDAR clustering and supplements each object by sampling spatially and semantically aligned points around it and (iii) Dynamic Query Balancing (DQB), which adaptively balances queries between foreground and background regions. Our extensive experiments on the nuScenes benchmark demonstrate that ALIGN consistently improves performance across multiple state-of-the-art detectors, achieving gains of up to +0.9 mAP and +1.2 NDS, particularly in challenging scenes with occlusions or dense crowds. Our code will be publicly available upon publication.

Mobile manipulators in households must both navigate and manipulate. This requires a compact, semantically rich scene representation that captures where objects are, how they function, and which parts are actionable. Scene graphs are a natural choice, yet prior work often separates spatial and functional relations, treats scenes as static snapshots without object states or temporal updates, and overlooks information most relevant for accomplishing the current task. To address these limitations, we introduce MomaGraph, a unified scene representation for embodied agents that integrates spatial-functional relationships and part-level interactive elements. However, advancing such a representation requires both suitable data and rigorous evaluation, which have been largely missing. We thus contribute MomaGraph-Scenes, the first large-scale dataset of richly annotated, task-driven scene graphs in household environments, along with MomaGraph-Bench, a systematic evaluation suite spanning six reasoning capabilities from high-level planning to fine-grained scene understanding. Built upon this foundation, we further develop MomaGraph-R1, a 7B vision-language model trained with reinforcement learning on MomaGraph-Scenes. MomaGraph-R1 predicts task-oriented scene graphs and serves as a zero-shot task planner under a Graph-then-Plan framework. Extensive experiments demonstrate that our model achieves state-of-the-art results among open-source models, reaching 71.6% accuracy on the benchmark (+11.4% over the best baseline), while generalizing across public benchmarks and transferring effectively to real-robot experiments.

Recent advances in generative AI have been largely driven by large language models (LLMs), deep neural networks that operate over discrete units called tokens. To represent text, the vast majority of LLMs use words or word fragments as the tokens, known as subword tokenization. Subword tokenization obscures fine-grained information, which is problematic, especially for scientific data - such as computer code or biological sequences - where meaning depends on the individual characters. Models that instead operate directly on the byte encoding of text avoid these limitations, but until now they have lagged behind subword-based models in performance. Here we introduce Bolmo, a family of fully open byte-level LLMs that approach the capabilities of subword-based systems. Using a two-stage conversion procedure, we transform existing subword-based models into byte-level models with minimal additional training. The resulting models outperform prior byte-level approaches and excel on character-level reasoning tasks, while remaining competitive across standard benchmarks. By efficiently processing byte-level information, these models achieve practical inference speeds and can be adapted at low cost using the existing ecosystem around the source LLM. Our results remove a long-standing performance barrier to end-to-end byte-level language modeling, demonstrating that models operating on raw text encodings can scale competitively while offering advantages in domains requiring fine-grained textual understanding.

In this work, we introduce FLAME, a family of extremely lightweight and capable Time Series Foundation Models, which support both deterministic and probabilistic forecasting via generative probabilistic modeling, thus ensuring both efficiency and robustness. FLAME utilizes the Legendre Memory for strong generalization capabilities. Through adapting variants of Legendre Memory, i.e., translated Legendre (LegT) and scaled Legendre (LegS), in the Encoding and Decoding phases, FLAME can effectively capture the inherent inductive bias within data and make efficient long-range inferences. To enhance the accuracy of probabilistic forecasting while keeping efficient, FLAME adopts a Normalization Flow based forecasting head, which can model the arbitrarily intricate distributions over the forecasting horizon in a generative manner. Comprehensive experiments on well-recognized benchmarks, including TSFM-Bench and ProbTS, demonstrate the consistent state-of-the-art zero-shot performance of FLAME on both deterministic and probabilistic forecasting tasks.

Biological foundation models (BioFMs), pretrained on large-scale biological sequences, have recently shown strong potential in providing meaningful representations for diverse downstream bioinformatics tasks. However, such models often rely on millions to billions of training sequences and billions of parameters, resulting in prohibitive computational costs and significant barriers to reproducibility and accessibility, particularly for academic labs. To address these challenges, we investigate the feasibility of data pruning for BioFM pretraining and propose a post-hoc influence-guided data pruning framework tailored to biological domains. Our approach introduces a subset-based self-influence formulation that enables efficient estimation of sample importance at low computational cost, and builds upon it two simple yet effective selection strategies, namely Top-k Influence (Top I) and Coverage-Centric Influence (CCI). We empirically validate our method on two representative BioFMs, RNA-FM and ESM-C. For RNA, our framework consistently outperforms random selection baselines under an extreme pruning rate of over 99 percent, demonstrating its effectiveness. Furthermore, we show the generalizability of our framework on protein-related tasks using ESM-C. In particular, our coreset even outperforms random subsets that are ten times larger in both RNA and protein settings, revealing substantial redundancy in biological sequence datasets. These findings underscore the potential of influence-guided data pruning to substantially reduce the computational cost of BioFM pretraining, paving the way for more efficient, accessible, and sustainable biological AI research.

Robotic manipulation requires both rich multimodal perception and effective learning frameworks to handle complex real-world tasks. See-through-skin (STS) sensors, which combine tactile and visual perception, offer promising sensing capabilities, while modern imitation learning provides powerful tools for policy acquisition. However, existing STS designs lack simultaneous multimodal perception and suffer from unreliable tactile tracking. Furthermore, integrating these rich multimodal signals into learning-based manipulation pipelines remains an open challenge. We introduce TacThru, an STS sensor enabling simultaneous visual perception and robust tactile signal extraction, and TacThru-UMI, an imitation learning framework that leverages these multimodal signals for manipulation. Our sensor features a fully transparent elastomer, persistent illumination, novel keyline markers, and efficient tracking, while our learning system integrates these signals through a Transformer-based Diffusion Policy. Experiments on five challenging real-world tasks show that TacThru-UMI achieves an average success rate of 85.5%, significantly outperforming the baselines of tactile policy(66.3%) and vision-only policy (55.4%). The system excels in critical scenarios, including contact detection with thin and soft objects and precision manipulation requiring multimodal coordination. This work demonstrates that combining simultaneous multimodal perception with modern learning frameworks enables more precise, adaptable robotic manipulation.

A fundamental challenge in numerical weather prediction is to efficiently produce high-resolution forecasts. A common solution is applying downscaling methods, which include dynamical downscaling and statistical downscaling, to the outputs of global models. This work focuses on statistical downscaling, which establishes statistical relationships between low-resolution and high-resolution historical data using statistical models. Deep learning has emerged as a powerful tool for this task, giving rise to various high-performance super-resolution models, which can be directly applied for downscaling, such as diffusion models and Generative Adversarial Networks. This work relies on a diffusion-based downscaling framework named CorrDiff. In contrast to the original work of CorrDiff, the region considered in this work is nearly 40 times larger, and we not only consider surface variables as in the original work, but also encounter high-level variables (six pressure levels) as target downscaling variables. In addition, a global residual connection is added to improve accuracy. In order to generate the 3km forecasts for the China region, we apply our trained models to the 25km global grid forecasts of CMA-GFS, an operational global model of the China Meteorological Administration (CMA), and SFF, a data-driven deep learning-based weather model developed from Spherical Fourier Neural Operators (SFNO). CMA-MESO, a high-resolution regional model, is chosen as the baseline model. The experimental results demonstrate that the forecasts downscaled by our method generally outperform the direct forecasts of CMA-MESO in terms of MAE for the target variables. Our forecasts of radar composite reflectivity show that CorrDiff, as a generative model, can generate fine-scale details that lead to more realistic predictions compared to the corresponding deterministic regression models.

A common and effective means for improving language model capabilities involves finetuning a ``student'' language model's parameters on generations from a more proficient ``teacher'' model. Termed ``synthetic data'', these generations are often produced before any student finetuning, but some work has considered generating new synthetic samples as training progresses. This paper studies and advocates for the latter case, where data are generated in an iterative, closed-loop fashion that is guided by the current state of the student model. For a fixed budget of generated samples, or a budget in terms of compute spent querying a teacher, we show that this curation of finetuning data affords improved student performance over static generation. Further, while there have been several LLM-specific methods proposed that operate in this regime, we find that simple, inexpensive selection criteria from the active learning literature tend to be most performant. We validate these claims across four mathematical and logical reasoning datasets using four different small language models.

The use of tiny devices capable of low-latency gesture recognition is gaining momentum in everyday human-computer interaction and especially in medical monitoring fields. Embedded solutions such as fall detection, rehabilitation tracking, and patient supervision require fast and efficient tracking of movements while avoiding unwanted false alarms. This study presents an efficient solution on how to build very efficient motion-based models only using triaxial accelerometer sensors. We explore the capability of the AutoML pipelines to extract the most important features from the data segments. This approach also involves training multiple lightweight machine learning algorithms using the extracted features. We use WeBe Band, a multi-sensor wearable device that is equipped with a powerful enough MCU to effectively perform gesture recognition entirely on the device. Of the models explored, we found that the neural network provided the best balance between accuracy, latency, and memory use. Our results also demonstrate that reliable real-time gesture recognition can be achieved in WeBe Band, with great potential for real-time medical monitoring solutions that require a secure and fast response time.

Repurposing approved drugs offers a time-efficient and cost-effective alternative to traditional drug development. However, in silico prediction of repurposing candidates is challenging and requires the effective collaboration of specialists in various fields, including pharmacology, medicine, biology, and bioinformatics. Fragmented, specialized algorithms and tools often address only narrow aspects of the overall problem. Heterogeneous, unstructured data landscapes require the expertise of specialized users. Hence, these data services do not integrate smoothly across workflows. With ChatDRex, we present a conversation-based, multi-agent system that facilitates the execution of complex bioinformatic analyses aiming for network-based drug repurposing prediction. It builds on the integrated systems medicine knowledge graph (NeDRex KG). ChatDRex provides natural language access to its extensive biomedical knowledge base. It integrates bioinformatics agents for network analysis, literature mining, and drug repurposing. These are complemented by agents that evaluate functional coherence for in silico validation. Its flexible multi-agent design assigns specific tasks to specialized agents, including query routing, data retrieval, algorithm execution, and result visualization. A dedicated reasoning module keeps the user in the loop and allows for hallucination detection. By enabling physicians and researchers without computer science expertise to control complex analyses with natural language, ChatDRex democratizes access to bioinformatics as an important resource for drug repurposing. It enables clinical experts to generate hypotheses and explore drug repurposing opportunities, ultimately accelerating the discovery of novel therapies and advancing personalized medicine and translational research. ChatDRex is publicly available at apps.cosy.bio/chatdrex.

Scientific reasoning through Large Language Models in heliophysics involves more than just recalling facts: it requires incorporating physical assumptions, maintaining consistent units, and providing clear scientific formats through coordinated approaches. To address these challenges, we present Reasoning With a Star, a newly contributed heliophysics dataset applicable to reasoning; we also provide an initial benchmarking approach. Our data are constructed from National Aeronautics and Space Administration & University Corporation for Atmospheric Research Living With a Star summer school problem sets and compiled into a readily consumable question-and-answer structure with question contexts, reasoning steps, expected answer type, ground-truth targets, format hints, and metadata. A programmatic grader checks the predictions using unit-aware numerical tolerance, symbolic equivalence, and schema validation. We benchmark a single-shot baseline and four multi-agent patterns, finding that decomposing workflows through systems engineering principles outperforms direct prompting on problems requiring deductive reasoning rather than pure inductive recall.

In multimodal graph learning, graph structures that integrate information from multiple sources, such as vision and text, can more comprehensively model complex entity relationships. However, the continuous growth of their data scale poses a significant computational bottleneck for training. Graph condensation methods provide a feasible path forward by synthesizing compact and representative datasets. Nevertheless, existing condensation approaches generally suffer from performance limitations in multimodal scenarios, mainly due to two reasons: (1) semantic misalignment between different modalities leads to gradient conflicts; (2) the message-passing mechanism of graph neural networks further structurally amplifies such gradient noise. Based on this, we propose Structural Regularized Gradient Matching (SR-GM), a condensation framework for multimodal graphs. This method alleviates gradient conflicts between modalities through a gradient decoupling mechanism and introduces a structural damping regularizer to suppress the propagation of gradient noise in the topology, thereby transforming the graph structure from a noise amplifier into a training stabilizer. Extensive experiments on four multimodal graph datasets demonstrate the effectiveness of SR-GM, highlighting its state-of-the-art performance and cross-architecture generalization capabilities in multimodal graph dataset condensation.

Driven by recent advances in vision-language models (VLMs) and egocentric perception research, the emerging topic of an egocentric procedural AI assistant (EgoProceAssist) is introduced to step-by-step support daily procedural tasks in a first-person view. In this paper, we start by identifying three core tasks in EgoProceAssist: egocentric procedural error detection, egocentric procedural learning, and egocentric procedural question answering, then introduce two enabling dimensions: real-time and streaming video understanding, and proactive interaction in procedural contexts. We define these tasks within a new taxonomy as the EgoProceAssist's essential functions and illustrate how they can be deployed in real-world scenarios for daily activity assistants. Specifically, our work encompasses a comprehensive review of current techniques, relevant datasets, and evaluation metrics across these five core areas. To clarify the gap between the proposed EgoProceAssist and existing VLM-based assistants, we conduct novel experiments to provide a comprehensive evaluation of representative VLM-based methods. Through these findings and our technical analysis, we discuss the challenges ahead and suggest future research directions. Furthermore, an exhaustive list of this study is publicly available in an active repository that continuously collects the latest work: https://github.com/z1oong/Building-Egocentric-Procedural-AI-Assistant.

Large language models (LLMs) are increasingly deployed in agentic and multi-turn workflows where they are tasked to perform actions of significant consequence. In order to deploy them reliably and manage risky outcomes in these settings, it is helpful to access model uncertainty estimates. However, confidence elicitation methods for LLMs are typically not evaluated directly in agentic settings; instead, they are evaluated on static datasets, such as Q&A benchmarks. In this work we investigate the relationship between confidence estimates elicited in static settings and the behavior of LLMs in interactive settings. We uncover a significant action-belief gap -- LLMs frequently take actions that contradict their elicited confidences. In a prediction market setting, we find that models often bet against their own high-confidence predictions; in a tool-use setting, models fail to reliably invoke information-seeking tools when their internal confidence is low; and in a user-challenge setting, models change their answers when they have high confidence in them, whilst sticking to answers they have low confidence in. Crucially, we show that static calibration is an insufficient predictor of consistency in the above dynamic settings, as stronger, better calibrated models are somtimes less consistent than their smaller and weaker open-source counterparts. Our results highlight a critical blind spot in current evaluation methodologies: ensuring that a model knows what it knows does not guarantee that it will act rationally on that knowledge.

Reinforcement Learning from Human Feedback (RLHF) is a methodology that aligns agent behavior with human preferences by integrating user feedback into the agent's training process. This paper introduces a framework that guides agent training through implicit neural signals, with a focus on the neural classification problem. Our work presents and releases a novel dataset of functional near-infrared spectroscopy (fNIRS) recordings collected from 25 human participants across three domains: Pick-and-Place Robot, Lunar Lander, and Flappy Bird. We train multiple classifiers to predict varying levels of agent performance (optimal, suboptimal, or worst-case) from windows of preprocessed fNIRS features, achieving an average F1 score of 67% for binary and 46% for multi-class classification across conditions and domains. We also train multiple regressors to predict the degree of deviation between an agent's chosen action and a set of near-optimal policy actions, providing a continuous measure of performance. Finally, we evaluate cross-subject generalization and show that fine-tuning pre-trained models with a small sample of subject-specific data increases average F1 scores by 17% and 41% for binary and multi-class models, respectively. Our results demonstrate that mapping implicit fNIRS signals to agent performance is feasible and can be improved, laying the foundation for future Reinforcement Learning from Neural Feedback (RLNF) systems.

Multilingual Large Language Models (LLMs) can process many languages, yet how they internally represent this diversity remains unclear. Do they form shared multilingual representations with language-specific decoding, and if so, why does performance favor the dominant training language? To address this, we train models on different multilingual mixtures and analyze their internal mechanisms using Cross-Layer Transcoders (CLTs) and Attribution Graphs. Our results reveal multilingual shared representations: the model employs highly similar features across languages, while language-specific decoding emerges in later layers. Training models without English shows identical multilingual shared space structures. Decoding relies partly on a small set of high-frequency features in the final layers, which linearly encode language identity from early layers. Intervening on these features allows one language to be suppressed and another substituted. Finally, to explain non-English failures, we perform a Model-Diffing experiment: underperformance arises from dim late-layer features, weak middle-layer clusters, and tokenizer bias toward English that forces early layers to specialize in word reassembly. Finetuning strengthens these features and their links, improving token assembly and language-specific decoding, providing a mechanistic explanation for multilingual gaps. Our models and CLTs are available at https://huggingface.co/collections/CausalNLP/multilingual-clts and https://huggingface.co/collections/CausalNLP/multilingual-gpt2-models. Our code is available at: https://github.com/abirharrasse/MultilingualCLTs