The increasingly crowded radio frequency (RF) spectrum forces communication signals to coexist, creating heterogeneous interferers whose structure often departs from Gaussian models. Recovering the interference-contaminated signal of interest in such settings is a central challenge, especially in single-channel RF processing. Existing data-driven methods often assume that the interference type is known, yielding ensembles of specialized models that scale poorly with the number of interferers. We show that detect-then-separate (DTS) strategies admit an analytical justification: within a Gaussian mixture framework, a plug-in maximum a posteriori detector followed by type-conditioned optimal estimation achieves asymptotic minimum mean-square error optimality under a mild temporal-diversity condition. This makes DTS a principled benchmark, but its reliance on multiple type-specific models limits scalability. Motivated by this, we propose a unified joint model (UJM), in which a single deep neural architecture learns to jointly detect and separate when applied directly to the received signal. Using tailored UNet architectures for baseband (complex-valued) RF signals, we compare DTS and UJM on synthetic and recorded interference types, showing that a capacity-matched UJM can match oracle-aided DTS performance across diverse signal-to-interference-and-noise ratios, interference types, and constellation orders, including mismatched training and testing type-uncertainty proportions. These findings highlight UJM as a scalable and practical alternative to DTS, while opening new directions for unified separation under broader regimes.

Software Engineering (SE) agents have shown promising abilities in supporting various SE tasks. Current SE agents remain fundamentally reactive, making decisions mainly based on conversation history and the most recent response. However, this reactive design provides no explicit structure or persistent state within the agent's memory, making long-horizon reasoning challenging. As a result, SE agents struggle to maintain a coherent understanding across reasoning steps, adapt their hypotheses as new evidence emerges, or incorporate execution feedback into the mental reasoning model of the system state. In this position paper, we argue that, to further advance SE agents, we need to move beyond reactive behavior toward a structured, state-aware, and execution-grounded reasoning. We outline how explicit structure, persistent and evolving state, and the integration of execution-grounded feedback can help SE agents perform more coherent and reliable reasoning in long-horizon tasks. We also provide an initial roadmap for developing next-generation SE agents that can more effectively perform real-world tasks.

As the paradigm of Human-Centered AI (HCAI) gains prominence, its benefits to society are accompanied by significant ethical concerns, one of which is the protection of individual privacy. This chapter provides a comprehensive overview of privacy within HCAI, proposing a human-centered privacy (HCP) framework, providing integrated solution from technology, ethics, and human factors perspectives. The chapter begins by mapping privacy risks across each stage of AI development lifecycle, from data collection to deployment and reuse, highlighting the impact of privacy risks on the entire system. The chapter then introduces privacy-preserving techniques such as federated learning and dif erential privacy. Subsequent chapters integrate the crucial user perspective by examining mental models, alongside the evolving regulatory and ethical landscapes as well as privacy governance. Next, advice on design guidelines is provided based on the human-centered privacy framework. After that, we introduce practical case studies across diverse fields. Finally, the chapter discusses persistent open challenges and future research directions, concluding that a multidisciplinary approach, merging technical, design, policy, and ethical expertise, is essential to successfully embed privacy into the core of HCAI, thereby ensuring these technologies advance in a manner that respects and ensures human autonomy, trust and dignity.

TabPFN is a transformer that achieves state-of-the-art performance on supervised tabular tasks by amortizing Bayesian prediction into a single forward pass. However, there is currently no method for uncertainty decomposition in TabPFN. Because it behaves, in an idealised limit, as a Bayesian in-context learner, we cast the decomposition challenge as a Bayesian predictive inference (BPI) problem. The main computational tool in BPI, predictive Monte Carlo, is challenging to apply here as it requires simulating unmodeled covariates. We therefore pursue the asymptotic alternative, filling a gap in the theory for supervised settings by proving a predictive CLT under quasi-martingale conditions. We derive variance estimators determined by the volatility of predictive updates along the context. The resulting credible bands are fast to compute, target epistemic uncertainty, and achieve near-nominal frequentist coverage. For classification, we further obtain an entropy-based uncertainty decomposition.

The rise of Large Language Models (LLMs) and Retrieval-Augmented Generation (RAG) has rapidly increased the need for high-quality, curated information retrieval datasets. These datasets, however, are currently created with off-the-shelf annotation tools that make the annotation process complex and inefficient. To streamline this process, we developed a specialized annotation tool - AIANO. By adopting an AI-augmented annotation workflow that tightly integrates human expertise with LLM assistance, AIANO enables annotators to leverage AI suggestions while retaining full control over annotation decisions. In a within-subject user study ($n = 15$), participants created question-answering datasets using both a baseline tool and AIANO. AIANO nearly doubled annotation speed compared to the baseline while being easier to use and improving retrieval accuracy. These results demonstrate that AIANO's AI-augmented approach accelerates and enhances dataset creation for information retrieval tasks, advancing annotation capabilities in retrieval-intensive domains.

Emerging networked systems such as industrial IoT and real-time cyber-physical infrastructures demand intelligent scheduling strategies capable of adapting to dynamic traffic, deadlines, and interference constraints. In this work, we present a novel Digital Twin-enabled scheduling framework inspired by Dual Mind World Model (DMWM) architecture, for learning-informed and imagination-driven network control. Unlike conventional rule-based or purely data-driven policies, the proposed DMWM combines short-horizon predictive planning with symbolic model-based rollout, enabling the scheduler to anticipate future network states and adjust transmission decisions accordingly. We implement the framework in a configurable simulation testbed and benchmark its performance against traditional heuristics and reinforcement learning baselines under varied traffic conditions. Our results show that DMWM achieves superior performance in bursty, interference-limited, and deadline-sensitive environments, while maintaining interpretability and sample efficiency. The proposed design bridges the gap between network-level reasoning and low-overhead learning, marking a step toward scalable and adaptive NDT-based network optimization.

Conspiracy theories can threaten society by spreading misinformation, deepening polarization, and eroding trust in democratic institutions. Social media often fuels the spread of conspiracies, primarily driven by two key actors: Superspreaders -- influential individuals disseminating conspiracy content at disproportionately high rates, and Bots -- automated accounts designed to amplify conspiracies strategically. To counter the spread of conspiracy theories, it is critical to both identify these actors and to better understand their behavior. However, a systematic analysis of these actors as well as real-world-applicable identification methods are still lacking. In this study, we leverage over seven million tweets from the COVID-19 pandemic to analyze key differences between Human Superspreaders and Bots across dimensions such as linguistic complexity, toxicity, and hashtag usage. Our analysis reveals distinct communication strategies: Superspreaders tend to use more complex language and substantive content while relying less on structural elements like hashtags and emojis, likely to enhance credibility and authority. By contrast, Bots favor simpler language and strategic cross-usage of hashtags, likely to increase accessibility, facilitate infiltration into trending discussions, and amplify reach. To counter both Human Superspreaders and Bots, we propose and evaluate 27 novel metrics for quantifying the severity of conspiracy theory spread. Our findings highlight the effectiveness of an adapted H-Index for computationally feasible identification of Human Superspreaders. By identifying behavioral patterns unique to Human Superspreaders and Bots as well as providing suitable identification methods, this study provides a foundation for mitigation strategies, including platform moderation policies, temporary and permanent account suspensions, and public awareness campaigns.

Understanding and classifying user personas is critical for delivering effective personalization. While persona information offers valuable insights, its full potential is realized only when contextualized, linking user characteristics with situational context to enable more precise and meaningful service provision. Existing systems often treat persona and context as separate inputs, limiting their ability to generate nuanced, adaptive interactions. To address this gap, we present PersoPilot, an agentic AI-Copilot that integrates persona understanding with contextual analysis to support both end users and analysts. End users interact through a transparent, explainable chat interface, where they can express preferences in natural language, request recommendations, and receive information tailored to their immediate task. On the analyst side, PersoPilot delivers a transparent, reasoning-powered labeling assistant, integrated with an active learning-driven classification process that adapts over time with new labeled data. This feedback loop enables targeted service recommendations and adaptive personalization, bridging the gap between raw persona data and actionable, context-aware insights. As an adaptable framework, PersoPilot is applicable to a broad range of service personalization scenarios.

Agreement Technologies refer to open computer systems in which autonomous software agents interact with one another, typically on behalf of humans, in order to come to mutually acceptable agreements. With the advance of AI systems in recent years, it has become apparent that such agreements, in order to be acceptable to the involved parties, must remain aligned with ethical principles and moral values. However, this is notoriously difficult to ensure, especially as different human users (and their software agents) may hold different value systems, i.e. they may differently weigh the importance of individual moral values. Furthermore, it is often hard to specify the precise meaning of a value in a particular context in a computational manner. Methods to estimate value systems based on human-engineered specifications, e.g. based on value surveys, are limited in scale due to the need for intense human moderation. In this article, we propose a novel method to automatically \emph{learn} value systems from observations and human demonstrations. In particular, we propose a formal model of the \emph{value system learning} problem, its instantiation to sequential decision-making domains based on multi-objective Markov decision processes, as well as tailored preference-based and inverse reinforcement learning algorithms to infer value grounding functions and value systems. The approach is illustrated and evaluated by two simulated use cases.

Naturalistic fMRI characterizes the brain as a dynamic predictive engine driven by continuous sensory streams. However, modeling the causal forward evolution in realistic neural simulation is impeded by the timescale mismatch between multimodal inputs and the complex topology of cortical networks. To address these challenges, we introduce BrainVista, a multimodal autoregressive framework designed to model the causal evolution of brain states. BrainVista incorporates Network-wise Tokenizers to disentangle system-specific dynamics and a Spatial Mixer Head that captures inter-network information flow without compromising functional boundaries. Furthermore, we propose a novel Stimulus-to-Brain (S2B) masking mechanism to synchronize high-frequency sensory stimuli with hemodynamically filtered signals, enabling strict, history-only causal conditioning. We validate our framework on Algonauts 2025, CineBrain, and HAD, achieving state-of-the-art fMRI encoding performance. In long-horizon rollout settings, our model yields substantial improvements over baselines, increasing pattern correlation by 36.0\% and 33.3\% on relative to the strongest baseline Algonauts 2025 and CineBrain, respectively.

Constructing mechanistic models of neural circuits is a fundamental goal of neuroscience, yet verifying such models is limited by the lack of ground truth. To rigorously test model discovery, we establish an in silico testbed using neuromechanical simulations of a larval zebrafish as a transparent ground truth. We find that LLM-based tree search autonomously discovers predictive models that significantly outperform established forecasting baselines. Conditioning on sensory drive is necessary but not sufficient for faithful system identification, as models exploit statistical shortcuts. Structural priors prove essential for enabling robust out-of-distribution generalization and recovery of interpretable mechanistic models. Our insights provide guidance for modeling real-world neural recordings and offer a broader template for AI-driven scientific discovery.

Large language models (LLMs) are being integrated into socially assistive robots (SARs) and other conversational agents providing mental health and well-being support. These agents are often designed to sound empathic and supportive in order to maximize user's engagement, yet it remains unclear how increasing the level of supportive framing in system prompts influences safety relevant behavior. We evaluated 6 LLMs across 3 system prompts with varying levels of supportiveness on 80 synthetic queries spanning 4 well-being domains (1440 responses). An LLM judge framework, validated against human ratings, assessed safety and care quality. Moderately supportive prompts improved empathy and constructive support while maintaining safety. In contrast, strongly validating prompts significantly degraded safety and, in some cases, care across all domains, with substantial variation across models. We discuss implications for prompt design, model selection, and domain specific safeguards in SARs deployment.

This letter proposes a novel three-tier content caching architecture for Vehicular Fog Caching (VFC)-assisted platoon, where the VFC is formed by the vehicles driving near the platoon. The system strategically coordinates storage across local platoon vehicles, dynamic VFC clusters, and cloud server (CS) to minimize content retrieval latency. To efficiently manage distributed storage, we integrate large language models (LLMs) for real-time and intelligent caching decisions. The proposed approach leverages LLMs' ability to process heterogeneous information, including user profiles, historical data, content characteristics, and dynamic system states. Through a designed prompting framework encoding task objectives and caching constraints, the LLMs formulate caching as a decision-making task, and our hierarchical deterministic caching mapping strategy enables adaptive requests prediction and precise content placement across three tiers without frequent retraining. Simulation results demonstrate the advantages of our proposed caching scheme.

The main contribution of this paper is to develop a hierarchical Bayesian formulation of PINNs for linear inverse problems, which is called BPINN-IP. The proposed methodology extends PINN to account for prior knowledge on the nature of the expected NN output, as well as its weights. Also, as we can have access to the posterior probability distributions, naturally uncertainties can be quantified. Also, variational inference and Monte Carlo dropout are employed to provide predictive means and variances for reconstructed images. Un example of applications to deconvolution and super-resolution is considered, details of the different steps of implementations are given, and some preliminary results are presented.

A/B testing on platforms often faces challenges from network interference, where a unit's outcome depends not only on its own treatment but also on the treatments of its network neighbors. To address this, cluster-level randomization has become standard, enabling the use of network-aware estimators. These estimators typically trim the data to retain only a subset of informative units, achieving low bias under suitable conditions but often suffering from high variance. In this paper, we first demonstrate that the interior nodes - units whose neighbors all lie within the same cluster - constitute the vast majority of the post-trimming subpopulation. In light of this, we propose directly averaging over the interior nodes to construct the mean-in-interior (MII) estimator, which circumvents the delicate reweighting required by existing network-aware estimators and substantially reduces variance in classical settings. However, we show that interior nodes are often not representative of the full population, particularly in terms of network-dependent covariates, leading to notable bias. We then augment the MII estimator with a counterfactual predictor trained on the entire network, allowing us to adjust for covariate distribution shifts between the interior nodes and full population. By rearranging the expression, we reveal that our augmented MII estimator embodies an analytical form of the point estimator within prediction-powered inference framework. This insight motivates a semi-supervised lens, wherein interior nodes are treated as labeled data subject to selection bias. Extensive and challenging simulation studies demonstrate the outstanding performance of our augmented MII estimator across various settings.

People increasingly seek advice online from both human peers and large language model (LLM)-based chatbots. Such advice rarely involves identifying a single correct answer; instead, it typically requires navigating trade-offs among competing values. We aim to characterize how LLMs navigate value trade-offs across different advice-seeking contexts. First, we examine the value trade-off structure underlying advice seeking using a curated dataset from four advice-oriented subreddits. Using a bottom-up approach, we inductively construct a hierarchical value framework by aggregating fine-grained values extracted from individual advice options into higher-level value categories. We construct value co-occurrence networks to characterize how values co-occur within dilemmas and find substantial heterogeneity in value trade-off structures across advice-seeking contexts: a women-focused subreddit exhibits the highest network density, indicating more complex value conflicts; women's, men's, and friendship-related subreddits exhibit highly correlated value-conflict patterns centered on security-related tensions (security vs. respect/connection/commitment); by contrast, career advice forms a distinct structure where security frequently clashes with self-actualization and growth. We then evaluate LLM value preferences against these dilemmas and find that, across models and contexts, LLMs consistently prioritize values related to Exploration & Growth over Benevolence & Connection. This systemically skewed value orientation highlights a potential risk of value homogenization in AI-mediated advice, raising concerns about how such systems may shape decision-making and normative outcomes at scale.

Prediction of crystal system from X-ray diffraction (XRD) spectra is a critical task in materials science, particularly for perovskite materials which are known for their diverse applications in photovoltaics, optoelectronics, and catalysis. In this study, we present a machine learning (ML)-driven framework that leverages advanced models, including Time Series Forest (TSF), Random Forest (RF), Extreme Gradient Boosting (XGBoost), Recurrent Neural Network (RNN), Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), and a simple feedforward neural network (NN), to classify crystal systems, point groups, and space groups from XRD data of perovskite materials. To address class imbalance and enhance model robustness, we integrated feature augmentation strategies such as Synthetic Minority Over-sampling Technique (SMOTE), class weighting, jittering, and spectrum shifting, along with efficient data preprocessing pipelines. The TSF model with SMOTE augmentation achieved strong performance for crystal system prediction, with a Matthews correlation coefficient (MCC) of 0.9, an F1 score of 0.92, and an accuracy of 97.76%. For point and space group prediction, balanced accuracies above 95% were obtained. The model demonstrated high performance for symmetry-distinct classes, including cubic crystal systems, point groups 3m and m-3m, and space groups Pnma and Pnnn. This work highlights the potential of ML for XRD-based structural characterization and accelerated discovery of perovskite materials

Embodied Artificial Intelligence (AI) is an intelligent system formed by agents and their environment through active perception, embodied cognition, and action interaction. Existing embodied AI remains confined to human-crafted setting, in which agents are trained on given memory and construct models for given tasks, enabling fixed embodiments to interact with relatively static environments. Such methods fail in in-the-wild setting characterized by variable embodiments and dynamic open environments. This paper introduces self-evolving embodied AI, a new paradigm in which agents operate based on their changing state and environment with memory self-updating, task self-switching, environment self-prediction, embodiment self-adaptation, and model self-evolution, aiming to achieve continually adaptive intelligence with autonomous evolution. Specifically, we present the definition, framework, components, and mechanisms of self-evolving embodied AI, systematically review state-of-the-art works for realized components, discuss practical applications, and point out future research directions. We believe that self-evolving embodied AI enables agents to autonomously learn and interact with environments in a human-like manner and provide a new perspective toward general artificial intelligence.

Prediction sets provide a means of quantifying the uncertainty in predictive tasks. Using held out calibration data, conformal prediction and risk control can produce prediction sets that exhibit statistically valid error control in a computationally efficient manner. However, in the standard formulations, the error is only controlled on average over many possible calibration datasets of fixed size. In this paper, we extend the control to remain valid with high probability over a cumulatively growing calibration dataset at any time point. We derive such guarantees using quantile-based arguments and illustrate the applicability of the proposed framework to settings involving distribution shift. We further establish a matching lower bound and show that our guarantees are asymptotically tight. Finally, we demonstrate the practical performance of our methods through both simulations and real-world numerical examples.

Maximum likelihood estimators (MLE) and control variate estimators (CVE) have been used in conjunction with known information across sketching algorithms and applications in machine learning. We prove that under certain conditions in an exponential family, an optimal CVE will achieve the same asymptotic variance as the MLE, giving an Expectation-Maximization (EM) algorithm for the MLE. Experiments show the EM algorithm is faster and numerically stable compared to other root finding algorithms for the MLE for the bivariate Normal distribution, and we expect this to hold across distributions satisfying these conditions. We show how the EM algorithm leads to reproducibility for algorithms using MLE / CVE, and demonstrate how the EM algorithm leads to finding the MLE when the CV weights are known.

The maximum mean discrepancy (MMD) is a kernel-based nonparametric statistic for two-sample testing, whose inferential accuracy depends critically on variance characterization. Existing work provides various finite-sample estimators of the MMD variance, often differing under the null and alternative hypotheses and across balanced or imbalanced sampling schemes. In this paper, we study the variance of the MMD statistic through its U-statistic representation and Hoeffding decomposition, and establish a unified finite-sample characterization covering different hypotheses and sample configurations. Building on this analysis, we propose an exact acceleration method for the univariate case under the Laplacian kernel, which reduces the overall computational complexity from $\mathcal O(n^2)$ to $\mathcal O(n \log n)$.

AI agents are increasingly used in long, multi-turn workflows in both research and enterprise settings. As interactions grow, agent behavior often degrades due to loss of constraint focus, error accumulation, and memory-induced drift. This problem is especially visible in real-world deployments where context evolves, distractions are introduced, and decisions must remain consistent over time. A common practice is to equip agents with persistent memory through transcript replay or retrieval-based mechanisms. While convenient, these approaches introduce unbounded context growth and are vulnerable to noisy recall and memory poisoning, leading to unstable behavior and increased drift. In this work, we introduce the Agent Cognitive Compressor (ACC), a bio-inspired memory controller that replaces transcript replay with a bounded internal state updated online at each turn. ACC separates artifact recall from state commitment, enabling stable conditioning while preventing unverified content from becoming persistent memory. We evaluate ACC using an agent-judge-driven live evaluation framework that measures both task outcomes and memory-driven anomalies across extended interactions. Across scenarios spanning IT operations, cybersecurity response, and healthcare workflows, ACC consistently maintains bounded memory and exhibits more stable multi-turn behavior, with significantly lower hallucination and drift than transcript replay and retrieval-based agents. These results show that cognitive compression provides a practical and effective foundation for reliable memory control in long-horizon AI agents.

Approximate nearest neighbor search (ANNS) is a core problem in machine learning and information retrieval applications. GPUs offer a promising path to high-performance ANNS: they provide massive parallelism for distance computations, are readily available, and can co-locate with downstream applications. Despite these advantages, current GPU-accelerated ANNS systems face three key limitations. First, real-world applications operate on evolving datasets that require fast batch updates, yet most GPU indices must be rebuilt from scratch when new data arrives. Second, high-dimensional vectors strain memory bandwidth, but current GPU systems lack efficient quantization techniques that reduce data movement without introducing costly random memory accesses. Third, the data-dependent memory accesses inherent to greedy search make overlapping compute and memory difficult, leading to reduced performance. We present Jasper, a GPU-native ANNS system with both high query throughput and updatability. Jasper builds on the Vamana graph index and overcomes existing bottlenecks via three contributions: (1) a CUDA batch-parallel construction algorithm that enables lock-free streaming insertions, (2) a GPU-efficient implementation of RaBitQ quantization that reduces memory footprint up to 8x without the random access penalties, and (3) an optimized greedy search kernel that increases compute utilization, resulting in better latency hiding and higher throughput. Our evaluation across five datasets shows that Jasper achieves up to 1.93x higher query throughput than CAGRA and achieves up to 80% peak utilization as measured by the roofline model. Jasper's construction scales efficiently and constructs indices an average of 2.4x faster than CAGRA while providing updatability that CAGRA lacks. Compared to BANG, the previous fastest GPU Vamana implementation, Jasper delivers 19-131x faster queries.

Autonomous vehicles (AVs) are rapidly advancing and are expected to play a central role in future mobility. Ensuring their safe deployment requires reliable interaction with other road users, not least pedestrians. Direct testing on public roads is costly and unsafe for rare but critical interactions, making simulation a practical alternative. Within simulation-based testing, adversarial scenarios are widely used to probe safety limits, but many prioritise difficulty over realism, producing exaggerated behaviours which may result in AV controllers that are overly conservative. We propose an alternative method, instead using a cognitively inspired pedestrian model featuring both inter-individual and intra-individual variability to generate behaviourally plausible adversarial scenarios. We provide a proof of concept demonstration of this method's potential for AV control optimisation, in closed-loop testing and tuning of an AV controller. Our results show that replacing the rule-based CARLA pedestrian with the human-like model yields more realistic gap acceptance patterns and smoother vehicle decelerations. Unsafe interactions occur only for certain pedestrian individuals and conditions, underscoring the importance of human variability in AV testing. Adversarial scenarios generated by this model can be used to optimise AV control towards safer and more efficient behaviour. Overall, this work illustrates how incorporating human-like road user models into simulation-based adversarial testing can enhance the credibility of AV evaluation and provide a practical basis to behaviourally informed controller optimisation.

Evolutionary Neural Architecture Search (ENAS) has gained attention for automatically designing neural network architectures. Recent studies use a neural predictor to guide the process, but the high computational costs of gathering training data -- since each label requires fully training an architecture -- make achieving a high-precision predictor with { limited compute budget (i.e., a capped number of fully trained architecture-label pairs)} crucial for ENAS success. This paper introduces ENAS with Dual Contrastive Learning (DCL-ENAS), a novel method that employs two stages of contrastive learning to train the neural predictor. In the first stage, contrastive self-supervised learning is used to learn meaningful representations from neural architectures without requiring labels. In the second stage, fine-tuning with contrastive learning is performed to accurately predict the relative performance of different architectures rather than their absolute performance, which is sufficient to guide the evolutionary search. Across NASBench-101 and NASBench-201, DCL-ENAS achieves the highest validation accuracy, surpassing the strongest published baselines by 0.05\% (ImageNet16-120) to 0.39\% (NASBench-101). On a real-world ECG arrhythmia classification task, DCL-ENAS improves performance by approximately 2.5 percentage points over a manually designed, non-NAS model obtained via random search, while requiring only 7.7 GPU-days.

The function of biomolecules such as proteins depends on their ability to interconvert between a wide range of structures or "conformations." Researchers have endeavored for decades to develop computational methods to predict the distribution of conformations, which is far harder to determine experimentally than a static folded structure. We present ConforMix, an inference-time algorithm that enhances sampling of conformational distributions using a combination of classifier guidance, filtering, and free energy estimation. Our approach upgrades diffusion models -- whether trained for static structure prediction or conformational generation -- to enable more efficient discovery of conformational variability without requiring prior knowledge of major degrees of freedom. ConforMix is orthogonal to improvements in model pretraining and would benefit even a hypothetical model that perfectly reproduced the Boltzmann distribution. Remarkably, when applied to a diffusion model trained for static structure prediction, ConforMix captures structural changes including domain motion, cryptic pocket flexibility, and transporter cycling, while avoiding unphysical states. Case studies of biologically critical proteins demonstrate the scalability, accuracy, and utility of this method.

Accurately simulating wave propagation is crucial in fields such as acoustics, electromagnetism, and seismic analysis. Traditional numerical methods, like finite difference and finite element approaches, are widely used to solve governing partial differential equations (PDEs) such as the Helmholtz equation. However, these methods face significant computational challenges when applied to high-frequency wave problems in complex two-dimensional domains. This work investigates Finite Basis Physics-Informed Neural Networks (FBPINNs) and their multilevel extensions as a promising alternative. These methods leverage domain decomposition, partitioning the computational domain into overlapping sub-domains, each governed by a local neural network. We assess their accuracy and computational efficiency in solving the Helmholtz equation for the homogeneous case, demonstrating their potential to mitigate the limitations of traditional approaches.

Early detection of oral cancer and potentially malignant diseases is a major challenge in low-resource settings due to the scarcity of annotated data. We provide a unified approach for four-class oral lesion classification that incorporates deep learning, spectral analysis, and demographic data. A pathologist-verified subset of oral cavity images was curated from a publicly available dataset. Oral cavity pictures were processed using a fine-tuned ConvNeXt-v2 network for deep embeddings before being translated into the hyperspectral domain using a reconstruction algorithm. Haemoglobin-sensitive, textural, and spectral descriptors were obtained from the reconstructed hyperspectral cubes and combined with demographic data. Multiple machine-learning models were evaluated using patient-specific validation. Finally, an incremental heuristic meta-learner (IHML) was developed that merged calibrated base classifiers via probabilistic feature stacking and uncertainty-aware abstraction of multimodal representations with patient-level smoothing. By decoupling evidence extraction from decision fusion, IHML stabilizes predictions in heterogeneous, small-sample medical datasets. On an unseen test set, our proposed model achieved a macro F1 of 66.23% and an overall accuracy of 64.56%. The findings demonstrate that RGB-to-hyperspectral reconstruction and ensemble meta-learning improve diagnostic robustness in real-world oral lesion screening.

Large language models show promise for vulnerability discovery, yet prevailing methods inspect code in isolation, struggle with long contexts, and focus on coarse function- or file-level detections that offer limited guidance to engineers who need precise line-level localization for targeted patches. We introduce T2L, an executable framework for project-level, line-level vulnerability localization that progressively narrows scope from repository modules to exact vulnerable lines via AST-based chunking and evidence-guided refinement. We provide a baseline agent with an Agentic Trace Analyzer (ATA) that fuses runtime evidence such as crash points and stack traces to translate failure symptoms into actionable diagnoses. To enable rigorous evaluation, we introduce T2L-ARVO, an expert-verified 50-case benchmark spanning five crash families in real-world projects. On T2L-ARVO, our baseline achieves up to 58.0% detection and 54.8% line-level localization rate. Together, T2L framework advance LLM-based vulnerability detection toward deployable, precision diagnostics in open-source software workflows.

Decoding the attended speaker in a multi-speaker environment from electroencephalography (EEG) has attracted growing interest in recent years, with neuro-steered hearing devices as a driver application. Current approaches typically rely on ground-truth labels of the attended speaker during training, necessitating calibration sessions for each user and each EEG set-up to achieve optimal performance. While unsupervised self-adaptive auditory attention decoding (AAD) for stimulus reconstruction has been developed to eliminate the need for labeled data, it suffers from an initialization bias that can compromise performance. Although an unbiased variant has been proposed to address this limitation, it introduces substantial computational complexity that scales with data size. This paper presents three computationally efficient alternatives that achieve comparable performance, but with a significantly lower and constant computational cost. The code for the proposed algorithms is available at https://github.com/YYao-42/Unsupervised_AAD.